A thermally triggered in situ hydrogel from poly(acrylic acid-co-N-isopropylacrylamide) for controlled release of anti-glaucoma drugs

2014 ◽  
Vol 2 (14) ◽  
pp. 1988 ◽  
Author(s):  
Adhimoorthy Prasannan ◽  
Hsieh-Chih Tsai ◽  
Yu-Shuan Chen ◽  
Ging-Ho Hsiue
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
In Situ Hydrogel ◽  
Thermally Triggered ◽  
Poly Acrylic Acid

Optimal response surface design of Gum tragacanth-based poly[(acrylic acid)-co-acrylamide] IPN hydrogel for the controlled release of the antihypertensive drug losartan potassium

RSC Advances ◽  
2014 ◽  
Vol 4 (75) ◽  
pp. 39822-39829 ◽  
Author(s):  
Saruchi Saruchi ◽  
B. S. Kaith ◽  
Rajeev Jindal ◽  
Vaneet Kumar ◽  
Manpreet S. Bhatti
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Polymer Network ◽  
Interpenetrating Polymer Network ◽  
Losartan Potassium ◽  
Surface Design ◽  
Gum Tragacanth ◽  
Ph Conditions ◽  
Poly Acrylic Acid

The present study proposes the development and optimization of a new interpenetrating polymer network (IPN), consisting of Gum tragacanth, poly(acrylic acid) (PAA), and poly(acrylamide) (PAAm), for the in situ controlled release of losartan potassium under different pH conditions at 37 °C.

Preparation and characterization of a novel pH-sensitive Salecan-g-poly(acrylic acid) hydrogel for controlled release of doxorubicin

2015 ◽  
Vol 3 (13) ◽  
pp. 2685-2697 ◽  
Author(s):  
Xinyu Hu ◽  
Wei Wei ◽  
Xiaoliang Qi ◽  
Hao Yu ◽  
Liandong Feng ◽  
...  
Keyword(s):  
Controlled Release ◽  
Acrylic Acid ◽  
Ph Sensitive ◽  
Swelling Behaviour ◽  
Poly Acrylic Acid

The pH-sensitive swelling behaviour and DOX release of Salecan-g-PAA hydrogels are discussed.

scholarly journals The interaction between self – assembling peptides and emodin and the controlled release of emodin from in-situ hydrogel

2019 ◽  
Vol 47 (1) ◽  
pp. 3961-3975 ◽  
Author(s):  
Weipeng Wei ◽  
Cui Meng ◽  
Yuhe Wang ◽  
Yongsheng Huang ◽  
Wenbin Du ◽  
...  
Keyword(s):  
Controlled Release ◽  
Self Assembling ◽  
In Situ Hydrogel

scholarly journals The Anomalous Influence of Polyelectrolyte Concentration on the Deposition and Nanostructure of Poly(ethyleneimine)/Poly(acrylic acid) Multilayers

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2141 ◽  
Author(s):  
Martin Müller
Keyword(s):  
Acrylic Acid ◽  
Attenuated Total Reflection ◽  
Silicon Substrates ◽  
Acid Base ◽  
Exponential Relationship ◽  
Individual Adsorption ◽  
The Individual ◽  
Poly Acrylic Acid

The deposition and nanostructure of polyelectrolyte (PEL) multilayers (PEMs) of branched poly(ethyleneimine)/poly(acrylic acid) (PEI/PAA) onto silicon substrates was studied in terms of the dependence of pH and the PEL concentration (cPEL) in the individual adsorption steps z. Both a commercial automatic dipping device and a homebuilt automatic stream coating device (flow cell) were used. Gravimetry, SFM, transmission (TRANS) and in situ attenuated total reflection (ATR) FTIR spectroscopy were used for the quantitative determination of the adsorbed amount, thickness, chemical composition and morphology of deposited PEMs, respectively. Firstly, the combination of pH = 10 for PEI and pH = 4 for PAA, where both PEL were predominantly in the neutral state, resulted in an extraordinarily high PEM deposition, while pH combinations, where one PEL component was charged, resulted in a significantly lower PEM deposition. This was attributed to both PEL conformation effects and acid/base interactions between basic PEI and acidic PAA. Secondly, for that pH combination an exponential relationship between PEM thickness and adsorption step z was found. Thirdly, based on the results of three independent methods, the course of the deposited amount of a PEM-10 (z = 10) versus cPEL in the range 0.001 to 0.015 M at pH = 10/4 was non-monotonous showing a pronounced maximum at cPEL = 0.005 M. Analogously, for cPEL = 0.005 M a maximum of roughness and structure size was found. Fourthly, related to that finding, in situ ATR-FTIR measurements gave evidence for the release of outermost located PEI upon PAA immersion (even step) and of outermost PAA upon PEI immersion (odd step) under formation of PEL complexes in solution. These studies help us to prepare PEL-based films with a defined thickness and morphology for interaction with biofluids in the biomedical and food fields.

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