scholarly journals Bimodal imaging using neodymium doped gadolinium fluoride nanocrystals with near-infrared to near-infrared downconversion luminescence and magnetic resonance properties

2013 ◽  
Vol 1 (41) ◽  
pp. 5702 ◽  
Author(s):  
L. Christopher Mimun ◽  
Gangadharan Ajithkumar ◽  
Madhab Pokhrel ◽  
Brian G. Yust ◽  
Zak G. Elliott ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Near Infrared ◽  
Bimodal Imaging ◽  
Resonance Properties

Targeted gold nanoshelled hybrid nanocapsules encapsulating doxorubicin for bimodal imaging and near-infrared triggered synergistic therapy of Her2-positve breast cancer

2020 ◽  
Vol 35 (3) ◽  
pp. 430-445
Author(s):  
Qi Dong ◽  
Caifeng Wan ◽  
Hong Yang ◽  
Dongdong Zheng ◽  
Li Xu ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Near Infrared ◽  
Average Diameter ◽  
Infrared Light ◽  
Resonance Imaging ◽  
Her2 Positive ◽  
Bimodal Imaging

A multifunctional targeted nanoplatform combining photothermal therapy and chemotherapy has emerged as a promising strategy for comprehensive therapies of breast cancer. In this study, we constructed human epidermal growth factor receptor 2 (Her2)-targeted gold nanoshelled poly(lactic- co-glycolic acid) hybrid nanocapsules encapsulating perfluorooctyl bromide, superparamagnetic iron oxide nanoparticles, and doxorubicin (Her2-GPDH nanocapsules) as theranostic agent for bimodal ultrasound/magnetic resonance imaging and synergistic photothermal-chemotherapy of Her2-postive breast cancer cells. Her2–GPDH nanocomposites possessed well-defined spherical morphology, and the average diameter was about 296 nm with good dispersion. Targeting assays demonstrated that Her2–GPDH nanocapsules exhibited higher targeting binding to Her2-positive SKBR3 cells than Her2-negative MDA-MB-231cells. The encapsulation efficiency and the loading content of doxorubicin in Her2–GPDH nanocapsules were 39 ± 1.45% and 3.8 ± 0.52%, respectively, and the agent exhibited pH-responsive and near-infrared light-triggered stepwise release behavior of doxorubicin. In vitro, the agent had potential to serve as feasible candidate for ultrasound imaging and T2-weighted magnetic resonance imaging with a relatively high relaxivity. Cell experiments confirmed that the agent had significant photothermal cytotoxicity on SKBR3 cells, and the combined photothermal–chemotherapy could significantly enhance the anti-tumor effect. In summary, the present Her2–GPDH nanocapsules, a novel multifunctional nanoplatform, will offer a new way for early bimodal molecular-level diagnosis and synergistic treatment of Her2-positve breast cancer.

scholarly journals Polydopamine-decorated tobacco mosaic virus for photoacoustic/magnetic resonance bimodal imaging and photothermal cancer therapy

Nanoscale ◽  
2019 ◽  
Vol 11 (19) ◽  
pp. 9760-9768 ◽  
Author(s):  
He Hu ◽  
Qi Yang ◽  
Simona Baroni ◽  
Hong Yang ◽  
Silvio Aime ◽  
...  
Keyword(s):  
Magnetic Resonance ◽  
Cancer Therapy ◽  
Tobacco Mosaic Virus ◽  
Mosaic Virus ◽  
Conversion Efficiency ◽  
Infrared Absorption ◽  
Near Infrared ◽  
Photothermal Conversion ◽  
Bimodal Imaging ◽  
Good Biocompatibility

The Gd-TMV–PDA nanotheranostic reagents demonstrated highly r1-relaxivity of ∼80 mM−1 s−1 at 60 MHz, strong near-infrared absorption with high photothermal conversion efficiency (28.9%), excellent photoacoustic contrast and good biocompatibility.

Monodisperse NaYbF4 : Tm3+/NaGdF4 core/shell nanocrystals with near-infrared to near-infrared upconversion photoluminescence and magnetic resonance properties

Nanoscale ◽  
2011 ◽  
Vol 3 (5) ◽  
pp. 2003 ◽  
Author(s):  
Guanying Chen ◽  
Tymish Y. Ohulchanskyy ◽  
Wing Cheung Law ◽  
Hans Ågren ◽  
Paras N. Prasad
Keyword(s):  
Magnetic Resonance ◽  
Near Infrared ◽  
Core Shell ◽  
Resonance Properties ◽  
Upconversion Photoluminescence

scholarly journals Design and Synthesis of Luminescent Lanthanide-Based Bimodal Nanoprobes for Dual Magnetic Resonance (MR) and Optical Imaging

Nanomaterials ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 354
Author(s):  
Walid Mnasri ◽  
Mahsa Parvizian ◽  
Souad Ammar-Merah
Keyword(s):  
Magnetic Resonance ◽  
Optical Imaging ◽  
Imaging Technique ◽  
Imaging Techniques ◽  
Design And Synthesis ◽  
Bimodal Imaging ◽  
Successive Image ◽  
Complete Set ◽  
Magnetic Resonance Imaging Mri ◽  
Physical And Chemical

Current biomedical imaging techniques are crucial for the diagnosis of various diseases. Each imaging technique uses specific probes that, although each one has its own merits, do not encompass all the functionalities required for comprehensive imaging (sensitivity, non-invasiveness, etc.). Bimodal imaging methods are therefore rapidly becoming an important topic in advanced healthcare. This bimodality can be achieved by successive image acquisitions involving different and independent probes, one for each mode, with the risk of artifacts. It can be also achieved simultaneously by using a single probe combining a complete set of physical and chemical characteristics, in order to record complementary views of the same biological object at the same time. In this scenario, and focusing on bimodal magnetic resonance imaging (MRI) and optical imaging (OI), probes can be engineered by the attachment, more or less covalently, of a contrast agent (CA) to an organic or inorganic dye, or by designing single objects containing both the optical emitter and MRI-active dipole. If in the first type of system, there is frequent concern that at some point the dye may dissociate from the magnetic dipole, it may not in the second type. This review aims to present a summary of current activity relating to this kind of dual probes, with a special emphasis on lanthanide-based luminescent nano-objects.

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