Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery

Ye Tian; Aleksandra Glogowska; Wen Zhong; Thomas Klonisch; Malcolm Xing

doi:10.1039/c3tb20544d

Polymeric mesoporous silica nanoparticles as a pH-responsive switch to control doxorubicin intracellular delivery

Journal of Materials Chemistry B ◽

10.1039/c3tb20544d ◽

2013 ◽

Vol 1 (39) ◽

pp. 5264 ◽

Cited By ~ 29

Author(s):

Ye Tian ◽

Aleksandra Glogowska ◽

Wen Zhong ◽

Thomas Klonisch ◽

Malcolm Xing

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Intracellular Delivery ◽

Ph Responsive

Download Full-text

In Vitro Evaluation of pH Responsive Doxazosin Loaded Mesoporous Silica Nanoparticles: A Smart Approach in Drug Delivery

Current Drug Delivery ◽

10.2174/1567201812666150722123704 ◽

2016 ◽

Vol 13 (4) ◽

pp. 574-581 ◽

Cited By ~ 3

Author(s):

Arijit Guha ◽

Nikhil Biswas ◽

Kaustav Bhattacharjee ◽

Piu Das ◽

Ketousetuo Kuotsu

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

In Vitro Evaluation

Download Full-text

Chitosan-glucuronic acid conjugate coated mesoporous silica nanoparticles: A smart pH-responsive and receptor-targeted system for colorectal cancer therapy

Carbohydrate Polymers ◽

10.1016/j.carbpol.2021.117893 ◽

2021 ◽

pp. 117893

Author(s):

Reema Narayan ◽

Shivaprasad Gadag ◽

Sri Pragnya Cheruku ◽

Ashok M. Raichur ◽

Candace Minhthu Day ◽

...

Keyword(s):

Colorectal Cancer ◽

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Glucuronic Acid ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

Acid Conjugate

Download Full-text

Surface Immobilization of pH-Responsive Polymer Brushes on Mesoporous Silica Nanoparticles by Enzyme Mimetic Catalytic ATRP for Controlled Cargo Release

Polymers ◽

10.3390/polym8080277 ◽

2016 ◽

Vol 8 (8) ◽

pp. 277 ◽

Cited By ~ 25

Author(s):

Hang Zhou ◽

Xin Wang ◽

Jun Tang ◽

Ying-Wei Yang

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Polymer Brushes ◽

Mesoporous Silica Nanoparticles ◽

Surface Immobilization ◽

Ph Responsive ◽

Enzyme Mimetic ◽

Responsive Polymer

Download Full-text

Fluorescent pH‐Responsive Mesoporous Silica Nanoparticles with Core‐Shell Feature as a Traceable Delivery Carrier for Ibuprofen

ChemistrySelect ◽

10.1002/slct.202000934 ◽

2020 ◽

Vol 5 (20) ◽

pp. 6123-6130

Author(s):

Tingting Wei ◽

Mengdi Sheng ◽

Chang Liu ◽

Jihong Sun ◽

Xia Wu ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Core Shell ◽

Ph Responsive

Download Full-text

pH-Triggered Charge-Reversal Mesoporous Silica Nanoparticles Stabilized by Chitosan Oligosaccharide/Carboxymethyl Chitosan Hybrids for Effective Intracellular Delivery of Doxorubicin

ACS Applied Bio Materials ◽

10.1021/acsabm.8b00830 ◽

2019 ◽

Vol 2 (5) ◽

pp. 1907-1919 ◽

Cited By ~ 11

Author(s):

Lan Cui ◽

Wentao Liu ◽

Hao Liu ◽

Qian Qin ◽

Shuangxia Wu ◽

...

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Intracellular Delivery ◽

Carboxymethyl Chitosan ◽

Chitosan Oligosaccharide ◽

Charge Reversal

Download Full-text

Synthesis of surface capped mesoporous silica nanoparticles for pH-stimuli responsive drug delivery applications

MedChemComm ◽

10.1039/c7md00270j ◽

2017 ◽

Vol 8 (9) ◽

pp. 1797-1805 ◽

Cited By ~ 9

Author(s):

Madhappan Santha Moorthy ◽

Subramanian Bharathiraja ◽

Panchanathan Manivasagan ◽

Kang Dae Lee ◽

Junghwan Oh

Keyword(s):

Drug Delivery ◽

Cancer Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Drug Carrier ◽

Stimuli Responsive ◽

Ph Responsive ◽

Drug Delivery Applications

Herein, we propose a “host–guest” complexation-based mesoporous silica drug carrier, MSNs@Mela@TTM, for pH-responsive drug delivery applications in cancer therapy.

Download Full-text

Nanoassemblies constructed from bimodal mesoporous silica nanoparticles and surface-coated multilayer pH-responsive polymer for controlled delivery of ibuprofen

Journal of Biomaterials Applications ◽

10.1177/0885328216653287 ◽

2016 ◽

Vol 31 (3) ◽

pp. 411-420 ◽

Cited By ~ 9

Author(s):

Yueyue Guo ◽

Jihong Sun ◽

Shiyang Bai ◽

Xiaoqi Jin

Keyword(s):

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Controlled Delivery ◽

Ph Responsive ◽

Responsive Polymer

Download Full-text

Hyaluronic acid targeted and pH-responsive nanocarriers based on hollow mesoporous silica nanoparticles for chemo-photodynamic combination therapy

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2020.111166 ◽

2020 ◽

Vol 194 ◽

pp. 111166 ◽

Cited By ~ 2

Author(s):

Kai Chen ◽

Cong Chang ◽

Zuhao Liu ◽

Yimin Zhou ◽

Qingni Xu ◽

...

Keyword(s):

Hyaluronic Acid ◽

Combination Therapy ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

Hollow Mesoporous Silica

Download Full-text

pH-responsive controlled release of mesoporous silica nanoparticles capped with Schiff base copolymer gatekeepers: Experiment and molecular dynamics simulation

Colloids and Surfaces B Biointerfaces ◽

10.1016/j.colsurfb.2019.01.024 ◽

2019 ◽

Vol 176 ◽

pp. 394-403 ◽

Cited By ~ 12

Author(s):

Shiyuan Peng ◽

Xiaozhe Yuan ◽

Wenjing Lin ◽

Chengzhi Cai ◽

Lijuan Zhang

Keyword(s):

Molecular Dynamics ◽

Schiff Base ◽

Molecular Dynamics Simulation ◽

Controlled Release ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Mesoporous Silica Nanoparticles ◽

Dynamics Simulation ◽

Ph Responsive

Download Full-text

Ultra-small mesoporous silica nanoparticles as efficient carriers for pH responsive releases of anti-cancer drugs

Dalton Transactions ◽

10.1039/c5dt03700j ◽

2015 ◽

Vol 44 (46) ◽

pp. 20186-20192 ◽

Cited By ~ 15

Author(s):

Haoquan Zheng ◽

Cheuk-Wai Tai ◽

Jie Su ◽

Xiaodong Zou ◽

Feifei Gao

Keyword(s):

Drug Delivery ◽

Mesoporous Silica ◽

Silica Nanoparticles ◽

Drug Delivery System ◽

Electrostatic Interactions ◽

Mesoporous Silica Nanoparticles ◽

Ph Responsive ◽

Drug Molecule ◽

Drug Molecules ◽

Anti Cancer

A pH-responsive drug delivery system via mesoporous silica nanoparticles as carriers can be achieved based on electrostatic interactions between drug molecules and carriers, when the isoelectric point of the drug molecule is high.

Download Full-text