Self-assembly of amphiphilic peptides into bio-functionalized nanotubes: a novel hydrolase model

2013 ◽  
Vol 1 (17) ◽  
pp. 2297 ◽  
Author(s):  
Zupeng Huang ◽  
Shuwen Guan ◽  
Yongguo Wang ◽  
Guannan Shi ◽  
Lina Cao ◽  
...  
Keyword(s):  
Self Assembly ◽  
Amphiphilic Peptides ◽  
Functionalized Nanotubes

scholarly journals Electrostatically Tuned Self-Assembly of Branched Amphiphilic Peptides

2014 ◽  
Vol 118 (29) ◽  
pp. 8624-8630 ◽  
Author(s):  
Christina L. Ting ◽  
Amalie L. Frischknecht ◽  
Mark J. Stevens ◽  
Erik D. Spoerke
Keyword(s):  
Self Assembly ◽  
Amphiphilic Peptides

scholarly journals Peptide Nanovesicles Formed by the Self-Assembly of Branched Amphiphilic Peptides

PLoS ONE ◽  
2012 ◽  
Vol 7 (9) ◽  
pp. e45374 ◽  
Author(s):  
Sushanth Gudlur ◽  
Pinakin Sukthankar ◽  
Jian Gao ◽  
L. Adriana Avila ◽  
Yasuaki Hiromasa ◽  
...  
Keyword(s):  
Self Assembly ◽  
The Self ◽  
Amphiphilic Peptides

scholarly journals Self-Assembly of Model Amphiphilic Peptides in Nonaqueous Solvents: Changing the Driving Force for Aggregation Does Not Change the Fibril Structure

Langmuir ◽  
2020 ◽  
Vol 36 (29) ◽  
pp. 8451-8460
Author(s):  
Alessandra Del Giudice ◽  
Axel Rüter ◽  
Nicolae Viorel Pavel ◽  
Luciano Galantini ◽  
Ulf Olsson
Keyword(s):  
Self Assembly ◽  
Driving Force ◽  
Nonaqueous Solvents ◽  
Amphiphilic Peptides ◽  
Fibril Structure

Molecular insights into the self-assembly of short amphiphilic peptides FmDn and FmKn

RSC Advances ◽  
2014 ◽  
Vol 4 (105) ◽  
pp. 60741-60748 ◽  
Author(s):  
Naresh Thota ◽  
Yijia Ma ◽  
Jianwen Jiang
Keyword(s):  
Molecular Dynamics ◽  
Molecular Dynamics Simulation ◽  
Self Assembly ◽  
The Self ◽  
Dynamics Simulation ◽  
Amphiphilic Peptides

Molecular dynamics simulation is reported for the self-assembly of short amphiphilic peptides FmDn and FmKn.

A redox-responsive mesoporous silica nanoparticle capped with amphiphilic peptides by self-assembly for cancer targeting drug delivery

Nanoscale ◽  
2015 ◽  
Vol 7 (22) ◽  
pp. 10071-10077 ◽  
Author(s):  
Dong Xiao ◽  
Hui-Zhen Jia ◽  
Ning Ma ◽  
Ren-Xi Zhuo ◽  
Xian-Zheng Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Cancer Cells ◽  
Self Assembly ◽  
Silica Nanoparticle ◽  
Cancer Targeting ◽  
Mesoporous Silica Nanoparticle ◽  
Amphiphilic Peptides ◽  
Redox Responsive

A novel redox-responsive mesoporous silica nanoparticle (RRMSN/DOX) capped with amphiphilic peptides by self-assembly was demonstrated for targeting drug delivery in cancer cells.

scholarly journals Self-assembly of amphiphilic peptides

Soft Matter ◽  
2011 ◽  
Vol 7 (9) ◽  
pp. 4122 ◽  
Author(s):  
I. W. Hamley
Keyword(s):  
Self Assembly ◽  
Amphiphilic Peptides

scholarly journals DNA-Based Applications in Nanobiotechnology

2010 ◽  
Vol 2010 ◽  
pp. 1-15 ◽  
Author(s):  
Khalid M. Abu-Salah ◽  
Anees A. Ansari ◽  
Salman A. Alrokayan
Keyword(s):  
Gene Delivery ◽  
Physical Properties ◽  
Self Assembly ◽  
Deoxyribonucleic Acid ◽  
Genetic Material ◽  
Optical Devices ◽  
Biological Molecules ◽  
Metallic Nanowires ◽  
Functionalized Nanotubes

Biological molecules such as deoxyribonucleic acid (DNA) have shown great potential in fabrication and construction of nanostructures and devices. The very properties that make DNA so effective as genetic material also make it a very suitable molecule for programmed self-assembly. The use of DNA to assemble metals or semiconducting particles has been extended to construct metallic nanowires and functionalized nanotubes. This paper highlights some important aspects of conjugating the unique physical properties of dots or wires with the remarkable recognition capabilities of DNA which could lead to miniaturizing biological electronics and optical devices, including biosensors and probes. Attempts to use DNA-based nanocarriers for gene delivery are discussed. In addition, the ecological advantages and risks of nanotechnology including DNA-based nanobiotechnology are evaluated.

Design and Characterization of Nanostructured Biomaterials via the Self-assembly of Lipids

2013 ◽  
Vol 1498 ◽  
pp. 233-238
Author(s):  
Paul Ludford ◽  
Fikret Aydin ◽  
Meenakshi Dutt
Keyword(s):  
Lipid Bilayers ◽  
Self Assembly ◽  
Dissipative Particle Dynamics ◽  
Building Blocks ◽  
Head Group ◽  
Specific Class ◽  
Multiple Control ◽  
Mesoscopic Simulation ◽  
Lipid Species ◽  
Functionalized Nanotubes

ABSTRACTWe are interested in designing nanostructured biomaterials using nanoscopic building blocks such as functionalized nanotubes and lipid molecules. In our earlier work, we summarized the multiple control parameters which direct the equilibrium morphology of a specific class of nanostructured biomaterials. Individual lipid molecules were composed of a hydrophilic head group and two hydrophobic tails. A bare nanotube encompassed an ABA architecture, with a hydrophobic shaft (B) and two hydrophilic ends (A). We introduced hydrophilic hairs at one end of the tube to enable selective transport through the channel. The dimensions of the nanotube were set to minimize its hydrophobic mismatch with the lipid bilayer. We used a Molecular Dynamics-based mesoscopic simulation technique called Dissipative Particle Dynamics which simultaneously resolves the structure and dynamics of the nanoscopic building blocks and the hybrid aggregate. The amphiphilic lipids and functionalized nanotubes self-assembled into a stable hybrid vesicle or a bicelle in the presence of a hydrophilic solvent. We showed that the morphology of the hybrid structures was directed by factors such as the temperature, the rigidity of the lipid molecules, and the concentration of the nanotubes. Another type of hybrid nanostructured biomaterial could be multi-component lipid bilayers. In this paper, we present approaches to design hybrid nanostructured materials using multiple lipid species with different chemistries and molecular chain stiffness.

Designing Tunable Bio-nanostructured Materials via Self-Assembly of Amphiphilic Lipids and Functionalized Nanotubes

2012 ◽  
Vol 1464 ◽  
Author(s):  
Meenakshi Dutt ◽  
Olga Kuksenok ◽  
Anna C. Balazs
Keyword(s):  
Self Assembly ◽  
Dissipative Particle Dynamics ◽  
Particle Dynamics ◽  
The Self ◽  
Hybrid Structures ◽  
Head Group ◽  
Group A ◽  
Hydrophilic Solvent ◽  
Stable Hybrid ◽  
Functionalized Nanotubes

ABSTRACTVia the Dissipative Particle Dynamics (DPD) approach, we study the self-assembly of hybrid structures comprising lipids and end-functionalized nanotubes. Individual lipids are composed of a hydrophilic head group and two hydrophobic tails. Each bare nanotube encompasses an ABA architecture, with a hydrophobic shaft (B) and two hydrophilic ends (A). To allow for regulated transport through the nanotube, we also introduce hydrophilic hairs at one end of the tube. The amphiphilic lipids are composed of a hydrophilic head group (A) and two hydrophobic tails (B). We select the dimensions of the nanotube architecture to minimize its hydrophobic mismatch with the lipid bilayer. We find the amphiphilic lipids and functionalized nanotubes to self-assemble into a stable hybrid vesicle or a bicelle in the presence of a hydrophilic solvent. We demonstrate that the morphology of the self-assembled functionalized nanotube-lipid hybrid structures is controlled by the rigidity of the lipid molecules and concentration of the nanotubes.

Tuning Secondary Structure and Self-Assembly of Amphiphilic Peptides

Langmuir ◽  
2005 ◽  
Vol 21 (2) ◽  
pp. 524-526 ◽  
Author(s):  
Dennis W. P. M. Löwik ◽  
Jaime Garcia-Hartjes ◽  
Joris T. Meijer ◽  
Jan C. M. van Hest
Keyword(s):  
Secondary Structure ◽  
Self Assembly ◽  
Amphiphilic Peptides
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