Direct monitoring of protein–protein inhibition using nano electrospray ionization mass spectrometry

2014 ◽  
Vol 5 (7) ◽  
pp. 2794-2803 ◽  
Author(s):  
Dragana Cubrilovic ◽  
Konstantin Barylyuk ◽  
Daniela Hofmann ◽  
Michal Jerzy Walczak ◽  
Martin Gräber ◽  
...  
Keyword(s):  
Mass Spectrometry ◽  
Electrospray Ionization ◽  
Protein Interactions ◽  
Electrospray Ionization Mass Spectrometry ◽  
Ionization Mass Spectrometry ◽  
Ionization Mass ◽  
Binding Mechanism ◽  
Protein Protein Interactions ◽  
Protein Inhibition

We investigated the inhibition of the protein–protein interactions by nanoESI-MS to monitor the extent of inhibition and the binding mechanism.

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