scholarly journals Selective carbohydrate–lectin interactions in covalent graphene- and SWCNT-based molecular recognition systems

2013 ◽  
Vol 4 (10) ◽  
pp. 4035 ◽  
Author(s):  
Maria-Eleni Ragoussi ◽  
Santiago Casado ◽  
Renato Ribeiro-Viana ◽  
Gema de la Torre ◽  
Javier Rojo ◽  
...  
Keyword(s):  
Molecular Recognition ◽  
Recognition Systems

scholarly journals Recombinase-Based Isothermal Amplification of Nucleic Acids with Self-Avoiding Molecular Recognition Systems (SAMRS)

ChemBioChem ◽  
2014 ◽  
Vol 15 (15) ◽  
pp. 2268-2274 ◽  
Author(s):  
Nidhi Sharma ◽  
Shuichi Hoshika ◽  
Daniel Hutter ◽  
Kevin M. Bradley ◽  
Steven A. Benner
Keyword(s):  
Molecular Recognition ◽  
Nucleic Acids ◽  
Isothermal Amplification ◽  
Recognition Systems

scholarly journals Re-evaluating the conventional wisdom about binding assays

2020 ◽  
Author(s):  
Brandon D. Wilson ◽  
H. Tom Soh
Keyword(s):  
Molecular Recognition ◽  
Conceptual Understanding ◽  
Single Molecule ◽  
Dynamic Range ◽  
Limit Of Detection ◽  
Conventional Wisdom ◽  
Binding Assays ◽  
Digital Measurements ◽  
Assay Design ◽  
Recognition Systems

AbstractAnalytical technologies based on binding assays have evolved substantially since their inception nearly 60 years ago, but our conceptual understanding of molecular recognition has not kept pace. Indeed, contemporary technologies such as single-molecule and digital measurements have challenged, or even rendered obsolete, core aspects of the conventional wisdom related to binding assay design. Here, we explore the fundamental principles underlying molecular recognition systems, which we consider in terms of signals generated through concentration-dependent shifts in equilibrium. We challenge certain orthodoxies related to binding-based detection assays, including the primary importance of a low KD and the extent to which this parameter constrains dynamic range and limit of detection. Lastly, we identify key principles for designing binding assays optimally suited for a given detection application.

scholarly journals Advances in Biomimetic Systems for Molecular Recognition and Biosensing

Biomimetics ◽  
2020 ◽  
Vol 5 (2) ◽  
pp. 20 ◽  
Author(s):  
Yeşeren Saylan ◽  
Özgecan Erdem ◽  
Fatih Inci ◽  
Adil Denizli
Keyword(s):  
Molecular Recognition ◽  
Molecularly Imprinted Polymers ◽  
Materials Science ◽  
Recent Literature ◽  
Current Knowledge ◽  
Molecularly Imprinted ◽  
Biomimetic Systems ◽  
Design Structure ◽  
Recognition Systems ◽  
And Function

Understanding the fundamentals of natural design, structure, and function has pushed the limits of current knowledge and has enabled us to transfer knowledge from the bench to the market as a product. In particular, biomimicry―one of the crucial strategies in this respect―has allowed researchers to tackle major challenges in the disciplines of engineering, biology, physics, materials science, and medicine. It has an enormous impact on these fields with pivotal applications, which are not limited to the applications of biocompatible tooth implants, programmable drug delivery systems, biocompatible tissue scaffolds, organ-on-a-chip systems, wearable platforms, molecularly imprinted polymers (MIPs), and smart biosensors. Among them, MIPs provide a versatile strategy to imitate the procedure of molecular recognition precisely, creating structural fingerprint replicas of molecules for biorecognition studies. Owing to their affordability, easy-to-fabricate/use features, stability, specificity, and multiplexing capabilities, host-guest recognition systems have largely benefitted from the MIP strategy. This review article is structured with four major points: (i) determining the requirement of biomimetic systems and denoting multiple examples in this manner; (ii) introducing the molecular imprinting method and reviewing recent literature to elaborate the power and impact of MIPs on a variety of scientific and industrial fields; (iii) exemplifying the MIP-integrated systems, i.e., chromatographic systems, lab-on-a-chip systems, and sensor systems; and (iv) closing remarks.

Multi-transduction of molecular recognition events in metalloporphyrin layers

2009 ◽  
Vol 13 (11) ◽  
pp. 1123-1128 ◽  
Author(s):  
Corrado Di Natale ◽  
Roberto Paolesse ◽  
Arnaldo D'Amico ◽  
Ingemar Lundström ◽  
Anita Lloyd-Spetz
Keyword(s):  
Molecular Recognition ◽  
Field Effect ◽  
Field Effect Transistors ◽  
Chemical Interaction ◽  
Recognition System ◽  
Electric Signal ◽  
Design And Synthesis ◽  
Effect Transistor ◽  
Recognition Systems ◽  
Selection Of

Besides the design and synthesis of appropriate molecular recognition systems, the development of chemical sensors requires a careful selection of the transducer to allow conversion of the chemical interaction into an exploitable electric signal. Metalloporphyrins, which are characterized by manifold of interactions of different strength and selectivity, provide a good example of the complexity of such an issue. In this paper, an example of the different ways to capture interactions occurring in a metalloporphyrin layer is presented. In particular, the properties of mass (quartz microbalance) and surface potential transducers (field effect transistor) are illustrated. Results suggest that field effect transistors are more suitable to preserve the interactions magnitude scale than to maintain the original selectivity of the molecular recognition system.

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