scholarly journals End-to-end continuous flow synthesis and purification of diphenhydramine hydrochloride featuring atom economy, in-line separation, and flow of molten ammonium salts

2013 ◽  
Vol 4 (7) ◽  
pp. 2822 ◽  
Author(s):  
David R. Snead ◽  
Timothy F. Jamison
Keyword(s):  
Continuous Flow ◽  
Ammonium Salts ◽  
Atom Economy ◽  
Flow Synthesis ◽  
Diphenhydramine Hydrochloride ◽  
Line Separation ◽  
End To End

Combining batch and continuous flow setups in the end-to-end synthesis of naturally occurring curcuminoids

2017 ◽  
Vol 2 (3) ◽  
pp. 366-374 ◽  
Author(s):  
Christian C. Carmona-Vargas ◽  
Leandro de C. Alves ◽  
Timothy J. Brocksom ◽  
Kleber T. de Oliveira
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Naturally Occurring ◽  
End To End

A successful end-to-end continuous flow synthesis of pure curcumin (1) and two other natural derivatives present in turmeric is described.

Rapid multigram scale end-to-end continuous flow synthesis of sulfonylurea anti-diabetes drugs: Gliclazide, chlorpropamide and tolbutamide

Synthesis ◽  
2021 ◽  
Author(s):  
Cloudius Sagandira ◽  
Paul Watts
Keyword(s):  
Residence Time ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Sulfonyl Urea ◽  
Flow Processes ◽  
End To End ◽  
Total Residence Time ◽  
Sulfonylurea Drugs

Herein we report multigram scale robust, efficient, and safe end-to-end continuous flow processes for the diabetes sulfonylurea drugs gliclazide, chlorpropamide and tolbutamide. The drugs were prepared via the treatment of an amine with a haloformate affording carbamate which was subsequently treated with a sulfonamide to afford sulfonylurea. Gliclazide was afforded in 87 % yield within 2.5 min total residence time with 26 g/h throughput; 0.2 Kg of the drug was produced in 8 h of running the system continuously. Chlorpropamide and tolbutamide were both afforded in 94 % yield within 1 min residence time with 184-188 g/h throughput; 1.4-1.5 Kg of the drugs was produced in 8 h of running the system continuously. N-substituted carbamates were used as safe alternatives to the hazardous isocyanates in constructing the sulfonyl urea moiety.

scholarly journals Assessing the possibilities of designing a unified multistep continuous flow synthesis platform

2018 ◽  
Vol 14 ◽  
pp. 1917-1936 ◽  
Author(s):  
Mrityunjay K Sharma ◽  
Roopashri B Acharya ◽  
Chinmay A Shukla ◽  
Amol A Kulkarni
Keyword(s):  
Detailed Analysis ◽  
Continuous Flow ◽  
Next Generation ◽  
One Pot ◽  
Complex Molecules ◽  
Flow Synthesis ◽  
One Pot Synthesis ◽  
Wide Range ◽  
Line Separation

The multistep flow synthesis of complex molecules has gained momentum over the last few years. A wide range of reaction types and conditions have been integrated seamlessly on a single platform including in-line separation as well as monitoring. Beyond merely getting considered as ‘flow version’ of conventional ‘one-pot synthesis’, multistep flow synthesis has become the next generation tool for creating libraries of new molecules. Here we give a more ‘engineering’ look at the possibility of developing a ‘unified multistep flow synthesis platform’. A detailed analysis of various scenarios is presented considering 4 different classes of drugs already reported in the literature. The possible complexities that an automated and controlled platform needs to handle are also discussed in detail. Three different design approaches are proposed: (i) one molecule at a time, (ii) many molecules at a time and (iii) cybernetic approach. Each approach would lead to the effortless integration of different synthesis stages and also at different synthesis scales. While one may expect such a platform to operate like a ‘driverless car’ or a ‘robo chemist’ or a ‘transformer’, in reality, such an envisaged system would be much more complex than these examples.

Continuous flow synthesis of the lamivudine precursor L-Menthyl Glyoxylate

2021 ◽  
Author(s):  
Lais S. D. Azevedo ◽  
Anderson R. Aguillon ◽  
Marcelo T. Lima ◽  
Raquel A. C. Leão ◽  
Rodrigo O. M. A. de Souza
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

Continuous Flow Synthesis of Persistent Luminescent Chromium-Doped Zinc Gallate Nanoparticles

2021 ◽  
pp. 7067-7075
Author(s):  
Xiaojun Wei ◽  
Stephen V. Kershaw ◽  
Xiaodan Huang ◽  
Mingxia Jiao ◽  
Chau Chun Beh ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Zinc Gallate

scholarly journals Continuous flow synthesis of azoxybenzenes by reductive dimerization of nitrosobenzenes with gel‐bound catalysts

2021 ◽  
Author(s):  
Carsten J. Schmiegel ◽  
Patrik Berg ◽  
Franziska Obst ◽  
Roland Schoch ◽  
Dietmar Appelhans ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis ◽  
Reductive Dimerization

scholarly journals Continuous Flow Synthesis of Metal–NHC Complexes**

2021 ◽  
Vol 27 (18) ◽  
pp. 5653-5657 ◽  
Author(s):  
Andreas Simoens ◽  
Thomas Scattolin ◽  
Thibault Cauwenbergh ◽  
Gianmarco Pisanò ◽  
Catherine S. J. Cazin ◽  
...  
Keyword(s):  
Continuous Flow ◽  
Flow Synthesis

scholarly journals Continuous‐Flow Synthesis of High‐Quality Few‐Layer Antimonene Hexagons

2021 ◽  
pp. 2101616
Author(s):  
Iñigo Torres ◽  
Marta Alcaraz ◽  
Roger Sanchis‐Gual ◽  
Jose A. Carrasco ◽  
Michael Fickert ◽  
...  
Keyword(s):  
Continuous Flow ◽  
High Quality ◽  
Flow Synthesis

scholarly journals Continuous-Flow Synthesis of Thioureas, Enabled by Aqueous Polysulfide Solution

Molecules ◽  
2021 ◽  
Vol 26 (2) ◽  
pp. 303
Author(s):  
András Gy. Németh ◽  
Renáta Szabó ◽  
György Orsy ◽  
István M. Mándity ◽  
György M. Keserű ◽  
...  
Keyword(s):  
Multicomponent Reaction ◽  
Continuous Flow ◽  
Flow Synthesis ◽  
Mild Conditions ◽  
Wide Range ◽  
Simple Filtration

We have developed the continuous-flow synthesis of thioureas in a multicomponent reaction starting from isocyanides, amidines, or amines and sulfur. The aqueous polysulfide solution enabled the application of sulfur under homogeneous and mild conditions. The crystallized products were isolated by simple filtration after the removal of the co-solvent, and the sulfur retained in the mother liquid. Presenting a wide range of thioureas synthesized by this procedure confirms the utility of the convenient continuous-flow application of sulfur.

scholarly journals Continuous‐Flow Synthesis of ZIF‐8 Biocomposites with Tunable Particle Size

2020 ◽  
Vol 59 (21) ◽  
pp. 8123-8127 ◽  
Author(s):  
Francesco Carraro ◽  
Jason D. Williams ◽  
Mercedes Linares‐Moreau ◽  
Chiara Parise ◽  
Weibin Liang ◽  
...  
Keyword(s):  
Particle Size ◽  
Continuous Flow ◽  
Flow Synthesis
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