Taurospongins B and C, new acetylenic fatty acid derivatives possessing a taurine amide residue from a marine sponge of the family Spongiidae

RSC Advances ◽  
2014 ◽  
Vol 4 (22) ◽  
pp. 11073-11079 ◽  
Author(s):  
Takaaki Kubota ◽  
Haruna Suzuki ◽  
Azusa Takahashi-Nakaguchi ◽  
Jane Fromont ◽  
Tohru Gonoi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives ◽  
The Family ◽  
Acetylenic Fatty Acid

Two new acetylenic fatty acid derivatives possessing a taurine amide residue, taurospongins B (1) and C (2), have been isolated from an Okinawan marine sponge of the family Spongiidae.

ChemInform Abstract: Taurospongins B and C, New Acetylenic Fatty Acid Derivatives Possessing a Taurine Amide Residue from a Marine Sponge of the Family Spongiidae.

ChemInform ◽  
2014 ◽  
Vol 45 (42) ◽  
pp. no-no
Author(s):  
Takaaki Kubota ◽  
Haruna Suzuki ◽  
Azusa Takahashi-Nakaguchi ◽  
Jane Fromont ◽  
Tohru Gonoi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives ◽  
The Family ◽  
Acetylenic Fatty Acid

Manzamenones L–N, new dimeric fatty-acid derivatives from an Okinawan marine sponge Plakortis sp.

2013 ◽  
Vol 23 (1) ◽  
pp. 244-247 ◽  
Author(s):  
Takaaki Kubota ◽  
Yuichiro Ishiguro ◽  
Azusa Takahashi-Nakaguchi ◽  
Jane Fromont ◽  
Tohru Gonoi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives

ChemInform Abstract: Manzamenones L-N, New Dimeric Fatty-Acid Derivatives from an Okinawan Marine Sponge Plakortis sp.

ChemInform ◽  
2013 ◽  
Vol 44 (20) ◽  
pp. no-no
Author(s):  
Takaaki Kubota ◽  
Yuichiro Ishiguro ◽  
Azusa Takahashi-Nakaguchi ◽  
Jane Fromont ◽  
Tohru Gonoi ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives

Manzamenones G and H, new dimeric fatty-acid derivatives from the Okinawan marine sponge Plakortis sp.

Tetrahedron ◽  
1993 ◽  
Vol 49 (27) ◽  
pp. 5955-5960 ◽  
Author(s):  
Jun'ichi Kobayashi ◽  
Sachiko Tsukamoto ◽  
Shinji Takeuchi ◽  
Masami Ishibashi
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives

ChemInform Abstract: Manzamenones G and H, New Dimeric Fatty-Acid Derivatives from the Okinawan Marine Sponge Plakortis Sp.

ChemInform ◽  
2010 ◽  
Vol 24 (43) ◽  
pp. no-no
Author(s):  
J. KOBAYASHI ◽  
S. TSUKAMOTO ◽  
S. TAKEUCHI ◽  
M. ISHIBASHI
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives

New fatty acid derivatives from Homaxinella sp., a marine sponge

Lipids ◽  
2005 ◽  
Vol 40 (9) ◽  
pp. 981-985 ◽  
Author(s):  
Tayyab A. Mansoor ◽  
Bok Hee Bae ◽  
Jongki Hong ◽  
Chong-O. Lee ◽  
Kwang Sik Im ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Marine Sponge ◽  
Fatty Acid Derivatives

Free Fatty Acid Receptors as New Potential Targets in Colorectal Cancer

2020 ◽  
Vol 21 (14) ◽  
pp. 1397-1404
Author(s):  
Adrian Bartoszek ◽  
Jakub Fichna ◽  
Aleksandra Tarasiuk ◽  
Agata Binienda ◽  
Adam Fabisiak ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acid ◽  
Free Fatty Acid ◽  
Current Knowledge ◽  
Developed Countries ◽  
Future Directions ◽  
Screening Programs ◽  
Pharmacological Targets ◽  
The Family ◽  
Free Fatty Acid Receptors

Colorectal cancer (CRC) is one of the most common cancers worldwide. In developed countries, its mortality remains high, yet the prevalence has established owing to effective screening programs; however due to the westernization of lifestyle, the incidences in many other countries have increased. Although the treatment of CRC has improved in the last few years, the side effects of these approaches cannot be neglected. Recently, members of the family of free fatty acid receptors (FFARs) have become attractive pharmacological targets in many diseases, including asthma; studies also point to their role in carcinogenesis. Here, we discuss current knowledge and future directions in FFAR research related to CRC. Contradictory results of FFARs modulation may derive from the pleiotropic effects of FFAR ligands, receptor distribution and different signal transduction. Hence, we indicate directions of further studies to fully use the potential of FFARs in CRC.

Fatty Acid Profile and In Vitro Anticancer Activity of Two Marine Sponge- Associated Bacteria

2020 ◽  
Vol 16 (9) ◽  
pp. 1273-1280
Author(s):  
Giuseppina Tommonaro ◽  
Ali M. El-Hagrassi ◽  
Walid Fayad ◽  
Carmine Iodice ◽  
Kamel H. Shaker ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Fatty Acids ◽  
Fatty Acid ◽  
Colorectal Carcinoma ◽  
Cell Line ◽  
Marine Sponge ◽  
Hct116 Cell ◽  
Associated Bacteria ◽  
Sponge Associated Bacteria ◽  
Human Colorectal Carcinoma

Background: Colorectal cancer represents one of the prominent causes of mortality worldwide in men and women. The objective of this study was to search for new potential anticancer compounds, both in prevention and treatment of colorectal cancer. The anticancer potential of marine bacterial extracts against Human colorectal carcinoma cell line (HCT116) was evaluated as well as the partial identification of bioactive metabolites. Methods: All bacterial extracts were tested for their cytotoxicity against HCT116 cell line by means of MTT assay. The highly cytotoxic dichloromethane extracts of marine sponge-associated bacteria Vibrio sp. and Bacillus sp. were analyzed by GC-MS. Results: Two fractions, Vib3 and Bac3, exhibited a very interesting cytotoxicity against human colorectal carcinoma (HCT116) cell line, with a percentage of cytotoxicity of 96.04 % and 29.48 %, respectively. Discussion: The GC-MS analysis revealed the presence of two major fatty acids, palmitic and oleic acids, in Vib3 fraction and fatty acid esters and phenolic compounds in Bac3 fraction. Conclusion: Based on previous literature, it may be hypothesized that the anticancer activity of bacterial extracts could be, at least partially, to the fatty acids fraction.

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