A novel polysulfone-based affinity membrane with high hemocompatibility: preparation and endotoxin elimination performance

RSC Advances ◽  
2013 ◽  
Vol 3 (48) ◽  
pp. 25982 ◽  
Author(s):  
Tiefan Huang ◽  
Mo Zhang ◽  
Lihua Cheng ◽  
Lin Zhang ◽  
Man Huang ◽  
...  
Keyword(s):  
Affinity Membrane ◽  
Endotoxin Elimination

scholarly journals The importance of early detection of endotoxemia

2016 ◽  
Vol 22 (7) ◽  
pp. 503-509 ◽  
Author(s):  
Barbara Adamik ◽  
Jakub Smiechowicz ◽  
Andrzej Kübler
Keyword(s):  
Septic Shock ◽  
Point Of Care ◽  
Point Of Care Testing ◽  
Clinical Challenge ◽  
Endotoxin Activity ◽  
Sepsis And Septic Shock ◽  
Clinical Conditions ◽  
Endotoxin Elimination ◽  
Selection Of Patients ◽  
Selection Of

Endotoxin is considered a key signaling molecule in the pathogenesis of sepsis and septic shock. Anti-endotoxin therapies may result in the improvement of a patient’s clinical condition and lower mortality. The pressing clinical challenge is to identify patients for whom endotoxin elimination would be the most beneficial. An endotoxin activity assay (EAA) has been available for detection of endotoxins, allowing selection of patients at high risk of endotoxemia in intensive care units (ICUs). We studied a cohort of 172 consecutive patients who had septic shock on admission to the ICU. Endotoxin activity (EA) was measured with a rapid chemiluminescent EAA, regarded as point-of-care testing. Endotoxemia with a mean EA of 0.59 ± 0.14 EAU was present in 104 patients (60%) and absent in 68 patients (EA = 0.25 ± 0.11 EAU). The risk of endotoxemia increased with the presence of a Gram-negative infection [odds ratio (OR) 3.1, 95% confidence interval (CI) 1.6–5.9; P = 0.001] and bacteremia (OR 3.8, 95% CI 1.6–8.9; P = 0.02) but did not change with a diagnosis of peritonitis (OR 1.03, 95% CI 0.54–1.97; P = 0.90). These findings indicate that anti-endotoxin interventions should be tailored to individual patients based on both clinical conditions and measured endotoxin levels.

scholarly journals A Simple Detection Method for Low-Affinity Membrane Protein Interactions by Baculoviral Display

PLoS ONE ◽  
2008 ◽  
Vol 3 (12) ◽  
pp. e4024 ◽  
Author(s):  
Toshiko Sakihama ◽  
Takato Sato ◽  
Hiroko Iwanari ◽  
Toshio Kitamura ◽  
Shimon Sakaguchi ◽  
...  
Keyword(s):  
Membrane Protein ◽  
Protein Interactions ◽  
Detection Method ◽  
Affinity Membrane ◽  
Simple Detection

Preparation of a modified crosslinked chitosan/polyvinyl alcohol blended affinity membrane for purification of His-tagged protein

2018 ◽  
Vol 136 (15) ◽  
pp. 47347 ◽  
Author(s):  
Rong Zeng ◽  
Bu-Kun Jin ◽  
Zhong-Hua Yang ◽  
Rong Guan ◽  
Can Quan
Keyword(s):  
Polyvinyl Alcohol ◽  
Affinity Membrane ◽  
Crosslinked Chitosan

Preparation and characterization of a cellulose affinity membrane for human immunoglobulin G (IgG) purification

2010 ◽  
Vol 348 (1-2) ◽  
pp. 224-230 ◽  
Author(s):  
Telma Barroso ◽  
Márcio Temtem ◽  
Abid Hussain ◽  
Ana Aguiar-Ricardo ◽  
Ana C.A. Roque
Keyword(s):  
Immunoglobulin G ◽  
Human Immunoglobulin ◽  
Human Immunoglobulin G ◽  
Affinity Membrane ◽  
Igg Purification

Removal of Endotoxin from Aqueous Solutions by Affinity Membrane

1997 ◽  
Vol 11 (3) ◽  
pp. 164-166 ◽  
Author(s):  
Wei Guo ◽  
Zhenhua Shang ◽  
Yinian Yu ◽  
Liangmo Zhou
Keyword(s):  
Aqueous Solutions ◽  
Affinity Membrane
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