Gelatin-based hydrogels with β-cyclodextrin as a dual functional component for enhanced drug loading and controlled release

RSC Advances ◽  
2013 ◽  
Vol 3 (47) ◽  
pp. 25041 ◽  
Author(s):  
Chengde Liu ◽  
Zhongxing Zhang ◽  
Xiao Liu ◽  
Xiping Ni ◽  
Jun Li
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Functional Component ◽  
Dual Functional

A novel anhydrous preparation of PEG hydrogels enables high drug loading with biologics for controlled release applications

2021 ◽  
Vol 147 ◽  
pp. 110286
Author(s):  
Christian E. Ziegler ◽  
Moritz Graf ◽  
Sebastian Beck ◽  
Achim M. Goepferich
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Peg Hydrogels ◽  
High Drug ◽  
High Drug Loading

scholarly journals ATRP-based synthesis of a pH-sensitive amphiphilic block polymer and its self-assembled micelles with hollow mesoporous silica as DOX carriers for controlled drug release

RSC Advances ◽  
2021 ◽  
Vol 11 (48) ◽  
pp. 29986-29996
Author(s):  
Xiuxiu Qi ◽  
Hongmei Yan ◽  
Yingxue Li
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Self Assembly ◽  
Drug Loading ◽  
Controlled Drug Release ◽  
Ph Sensitive ◽  
Core Shell ◽  
Assembly Process ◽  
Block Polymer ◽  
Hollow Mesoporous Silica

A pH-sensitive core–shell nanoparticle (HMS@C18@PSDMA-b-POEGMA) was developed via a self-assembly process as the carrier of anticancer drug doxorubicin (DOX) for drug loading and controlled release.

scholarly journals Biofunctionalization of decellularized porcine aortic valve with OPG-loaded PCL nanoparticles for anti-calcification

RSC Advances ◽  
2019 ◽  
Vol 9 (21) ◽  
pp. 11882-11893
Author(s):  
Yang Li ◽  
Yu Zhang ◽  
Jing-Li Ding ◽  
Ji-Chun Liu ◽  
Jian-Jun Xu ◽  
...  
Keyword(s):  
Tissue Engineering ◽  
Controlled Release ◽  
Aortic Valve ◽  
Drug Loading ◽  
Biological Factor ◽  
Engineering Technology ◽  
Loading System ◽  
Tissue Engineering Technology

A novel composite valve with controlled release OPG was prepared by introducing tissue engineering technology and nano drug-loading system to introduce anti-calcification biological factor OPG on the decellularized valve.

Controlled release of free doxorubicin from peptide–drug conjugates by drug loading

2014 ◽  
Vol 191 ◽  
pp. 123-130 ◽  
Author(s):  
Zhipeng Chen ◽  
Pengcheng Zhang ◽  
Andrew G. Cheetham ◽  
Jae Hyon Moon ◽  
James W. Moxley ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Peptide Drug ◽  
Drug Conjugates ◽  
Free Doxorubicin ◽  
Peptide Drug Conjugates

Facile Fabrication of 10-Hydroxycamptothecin-Backboned Amphiphilic Polyprodrug with Precisely Tailored Drug Loading Content for Controlled Release

2018 ◽  
Vol 29 (7) ◽  
pp. 2239-2247 ◽  
Author(s):  
Xiaolong Zhang ◽  
Mingkui Zhang ◽  
Mingqi Wang ◽  
Han Peng ◽  
Qi Hua ◽  
...  
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
Facile Fabrication

scholarly journals PREPARATION, CHARACTERISATION AND EVALUATION OF ROPINIROLE HYDROCHLORIDE LOADED CONTROLLED RELEASE MICROSPHERES USING SOLVENT EVAPORATION TECHNIQUE

2018 ◽  
Vol 10 (6) ◽  
pp. 57
Author(s):  
Koyel Kar ◽  
R. N. Pal ◽  
N. N. Bala
Keyword(s):  
Controlled Release ◽  
Drug Release ◽  
Release Kinetics ◽  
Drug Loading ◽  
Solvent Evaporation ◽  
In Vitro Drug Release ◽  
Aqueous Solvent ◽  
Evaporation Technique ◽  
Ropinirole Hydrochloride

Objective: The major objective of the research work was to design, characterise and evaluate controlled release microspheres of ropinirole hydrochloride by using non-aqueous solvent evaporation technique to facilitate the delivery of the drug at a predetermined rate for a specific period of time.Methods: Ropinirole hydrochloride microspheres were prepared by using different low-density polymers such as eudragit RL 100, eudragit RS 100 and ethylcellulose either alone or in combination with the help of non-aqueous solvent evaporation technique. All the formulated microparticles were subjected to various evaluation parameters such as particle size analysis, micrometric properties, drug entrapment efficiency, percentage drug loading, percentage yield and in vitro drug release study. The compatibility of the drug and polymers was confirmed by physical compatibility study, fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC) and x-ray diffraction study (XRD). The formation of the most optimized batch of the microsphere (F12) was confirmed by scanning electron microscopy (SEM), DSC, FTIR, and XRD. In vitro drug release study and in vitro drug release kinetics study of the formulated microspheres were also carried out.Results: Drug-polymer compatibility studies performed with the help of FTIR and DSC indicated that there were no interactions. Results revealed that non-aqueous solvent evaporation technique was a suitable technique for the preparation of microspheres as most of the formulations were discrete, free-flowing and spherical in shape with a good yield of 55.67% to 80.09%, percentage drug loading of 35.52% to 94.50% and percentage drug entrapment efficiency of 36.24% to 95.07%. Different drug-polymer ratios, as well as the combination of polymers, played a significant role in the variation of over-all characteristics of formulations. Based on the data of various evaluation parameters such as particle size analysis, percentage drug loading, percentage drug entrapment, percentage yield, rheological studies and in vitro drug release characteristics, formulation F12 was found to fulfil the criteria of ideal controlled release drug delivery system. F12 showed controlled release till the 14th hour (97.99%) and its in vitro release kinetics was best explained by zero-order kinetics and followed Korsemeyer-Pappas model (Non-Fickian mechanism). SEM of F12 revealed the formation of spherical structures. The FTIR study of F12 confirmed the stable nature of ropinirole in the drug-loaded microspheres. DSC and XRD patterns showed that ropinirole hydrochloride was dispersed at the molecular level in the polymer matrix.Conclusion: The controlled release microparticles were successfully prepared and from this study, it was concluded that the developed microspheres of ropinirole hydrochloride can be used for controlled drug release to improve the bioavailability and patient compliance and to maintain a constant drug level in the blood target tissue by releasing the drug in zero order pattern.

New Cyclodextrin Hydrogels Cross-Linked with Diglycidylethers with a High Drug Loading and Controlled Release Ability

2006 ◽  
Vol 23 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Carmen Rodriguez-Tenreiro ◽  
Carmen Alvarez-Lorenzo ◽  
Ana Rodriguez-Perez ◽  
Angel Concheiro ◽  
Juan J. Torres-Labandeira
Keyword(s):  
Controlled Release ◽  
Drug Loading ◽  
High Drug ◽  
High Drug Loading

Mechanically Modulated, Ultra-high Precision Logic Delivery of Molecules by Bio-inspired Macroporous Ceramic Sponge

MRS Advances ◽  
2017 ◽  
Vol 2 (19-20) ◽  
pp. 1125-1130 ◽  
Author(s):  
Changlu Xu ◽  
Yanjie Bai ◽  
Huilin Yang ◽  
Lei Yang
Keyword(s):  
Mechanical Properties ◽  
Controlled Release ◽  
Pore Structure ◽  
High Precision ◽  
Cyclic Deformation ◽  
Material Characterization ◽  
Drug Loading ◽  
Compressive Strain ◽  
Moisture Contents ◽  
Controlled Release System

ABSTRACTInspired by sea sponges, porous Al2O3/starch composite sponges were designed and fabricated as a new controlled release system enabling mechano-triggered logic delivery of molecules. Results of material characterization indicate that the all the composite sponges had a high macro-porosity of >80%, and dehydrated sponges revealed favorable pore structure for drug loading and retaining. The composite sponges have moisture-dependent mechanical properties and samples with appropriate moisture contents revealed high resilience and mechanical robustness under cyclic deformation. Based on the unique mechanical properties of the composite sponge, mechanically modulated, nano-gram precision delivery of model molecules was achieved in an AND logic manner gated by both moisture and compressive strain.

An enzyme-responsive controlled release system based on a dual-functional peptide

2016 ◽  
Vol 52 (29) ◽  
pp. 5112-5115 ◽  
Author(s):  
X. Li ◽  
S. Burger ◽  
A. J. O'Connor ◽  
L. Ong ◽  
J. A. Karas ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Mesoporous Silica Material ◽  
Release System ◽  
Dual Functional ◽  
Silica Material ◽  
Controlled Release System ◽  
Functional Peptide

A new controlled release system was developed by loading a dual-functional peptide on a mesoporous silica material.

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