scholarly journals Proline-coated gold nanoparticles as a highly efficient nanocatalyst for the enantioselective direct aldol reaction in water

RSC Advances ◽  
2013 ◽  
Vol 3 (12) ◽  
pp. 3861 ◽  
Author(s):  
Noureddine Khiar ◽  
Raquel Navas ◽  
Eleonora Elhalem ◽  
Victoria Valdivia ◽  
Inmaculada Fernández
Keyword(s):  
Gold Nanoparticles ◽  
Aldol Reaction ◽  
Highly Efficient ◽  
Direct Aldol Reaction ◽  
Reaction In Water

Highly Efficient and Reusable Dendritic Catalysts Derived fromN-Prolylsulfonamide for the Asymmetric Direct Aldol Reaction in Water

2006 ◽  
Vol 8 (20) ◽  
pp. 4417-4420 ◽  
Author(s):  
Yongyong Wu ◽  
Yazhu Zhang ◽  
Menglong Yu ◽  
Gang Zhao ◽  
Shaowu Wang
Keyword(s):  
Aldol Reaction ◽  
Highly Efficient ◽  
Direct Aldol Reaction ◽  
Reaction In Water

Synthesis of 1,2-Diamine Bifunctional Catalysts for the Direct Aldol Reaction Through Probing the Remote Amide Hydrogen

2019 ◽  
Vol 6 (2) ◽  
pp. 171-176
Author(s):  
Rajasekhar Dodda ◽  
Sampak Samanta ◽  
Matthew Su ◽  
John Cong-Gui Zhao
Keyword(s):  
Hydrogen Bonding ◽  
Catalytic Activity ◽  
Aldol Reaction ◽  
Catalytic Efficiency ◽  
Aldol Reactions ◽  
Catalyst Loading ◽  
Bifunctional Catalysts ◽  
Amide Hydrogen ◽  
Highly Efficient ◽  
Direct Aldol Reaction

Background: While proline can catalyze the asymmetric direct aldol reactions, its catalytic activity and catalyst turnover are both low. To improve the catalytic efficiency, many prolinebased organocatalysts have been developed. In this regard, prolinamide-based bifunctional catalysts have been demonstrated by us and others to be highly efficient catalysts for the direct aldol reactions. Results: Using the β-acetamido- and β-tosylamidoprolinamide catalysts, the highly enantio- and diastereoselective direct aldol reactions between enolizable ketones and aldehydes were achieved (up to >99% ee, 98:2 dr). A low catalyst loading of only 2-5 mol % of the β-tosylamidoprolinamide catalyst was needed to obtain the desired aldol products in good to high yields and high stereoselectivities. Methods: By carefully adjusting the hydrogen bonding ability of the remote β-amide hydrogen of the 1,2-diamine-based prolinamide bifunctional catalysts, the catalytic activity and the asymmetric induction of these catalysts were significantly improved for the direct aldol reaction between aldehydes and enolizable ketones. Conclusion: Some highly efficient 1,2-diamine-based bifunctional prolinamide catalysts have been developed through probing the remote β-amide hydrogen for its hydrogen bonding capability. These catalysts are easy to synthesize and high enantioselectivities may be achieved at very low catalyst loadings.

C2-Symmetric Bisprolinamide as a Highly Efficient Catalyst for Direct Aldol Reaction

2005 ◽  
Vol 7 (23) ◽  
pp. 5321-5323 ◽  
Author(s):  
Sampak Samanta ◽  
Jinyun Liu ◽  
Rajasekhar Dodda ◽  
Cong-Gui Zhao
Keyword(s):  
Aldol Reaction ◽  
Efficient Catalyst ◽  
Highly Efficient ◽  
Direct Aldol Reaction

ChemInform Abstract: Design, Synthesis and Organocatalysis of 2,2′-Biphenol-Based Prolinamide Organocatalysts in the Asymmetric Direct Aldol Reaction in Water.

ChemInform ◽  
2014 ◽  
Vol 45 (17) ◽  
pp. no-no
Author(s):  
Hong-Wu Zhao ◽  
Zhi-Hui Sheng ◽  
Wei Meng ◽  
Yuan-Yuan Yue ◽  
Hai-Long Li ◽  
...  
Keyword(s):  
Aldol Reaction ◽  
Design Synthesis ◽  
Direct Aldol Reaction ◽  
Reaction In Water
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