A DFT study on the NHC catalysed Michael addition of enols to α,β-unsaturated acyl-azoliums. A base catalysed C–C bond-formation step

2014 ◽  
Vol 12 (6) ◽  
pp. 895-904 ◽  
Author(s):  
Luis R. Domingo ◽  
José A. Sáez ◽  
Manuel Arnó
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Dft Study ◽  
Unsaturated Acyl ◽  
Formation Step

Topography of the Free Energy Landscape on the Claisen-Schmidt Condensation: Solvent and Temperature Effect in the Rate-Controlling Step

2021 ◽  
Author(s):  
Nayara Dantas Coutinho ◽  
Hugo Gontijo Machado ◽  
Valter Henrique Carvalho-Silva ◽  
Wender A. Silva
Keyword(s):  
Free Energy ◽  
Temperature Effect ◽  
Strong Influence ◽  
Aldol Condensation ◽  
Energy Landscape ◽  
Bond Formation ◽  
Free Energy Landscape ◽  
Rate Controlling Step ◽  
Formation Step

Recent studies have assigned hydroxide elimination and C=C bond formation step in base-promoted aldol condensation the role of having a strong influence in the overall rate reaction, in contrast to...

P−C and C−C Bond Formation by Michael Addition in Platinum-Catalyzed Hydrophosphination and in the Stoichiometric Reactions of Platinum Phosphido Complexes with Activated Alkenes

2006 ◽  
Vol 25 (24) ◽  
pp. 5757-5767 ◽  
Author(s):  
Corina Scriban ◽  
David S. Glueck ◽  
Lev N. Zakharov ◽  
W. Scott Kassel ◽  
Antonio G. DiPasquale ◽  
...  
Keyword(s):  
Michael Addition ◽  
Bond Formation

Synthesis of 1,4-dihydropyrazolo[4,3-b]indoles via intramolecular C(sp2)-N bond formation involving nitrene insertion, DFT study and their anticancer assessment

2021 ◽  
pp. 105114
Author(s):  
Manpreet Kaur ◽  
Vikrant Mehta ◽  
Aabid Abdullah Wani ◽  
Sahil Arora ◽  
Prasad V. Bharatam ◽  
...  
Keyword(s):  
Bond Formation ◽  
Dft Study

scholarly journals Michael Addition of Imidazole to α, β -Unsaturated Carbonyl/Cyano Compound

2018 ◽  
Vol 5 (1) ◽  
pp. 18-31
Author(s):  
Seetaram Mohapatra ◽  
Nilofar Baral ◽  
Nilima Priyadarsini Mishra ◽  
Pravati Panda ◽  
Sabita Nayak
Keyword(s):  
Organic Chemistry ◽  
Amino Acids ◽  
Anticancer Agents ◽  
Michael Addition ◽  
Addition Reaction ◽  
Bond Formation ◽  
Conjugate Addition ◽  
Michael Addition Reaction ◽  
Cyano Compounds ◽  
Nitrogen Bond

Introduction: Aza-Michael addition is an important reaction for carbon-nitrogen bond formation in synthetic organic chemistry. Expalantion: Conjugate addition of imidazole to α,β-unsaturated carbonyl/cyano compounds provides significant numbers of the biologically and synthetically interesting products, such as β-amino acids and β-lactams, which have attracted great attention for their use as key intermediates of anticancer agents, antibiotics and other drugs. Conclusion: This review addresses most significant method for the synthesis of N-substituted imidazole derivatives following Michael addition reaction of imidazole to α,β-unsaturated carbonyl/cyano compounds using ionic liquid/base/acid/enzyme as catalysts from year 2007-2017.

Selective synthesis of acylated caprolactam via sequential Michael addition/palladium-catalyzed alpha-arylation of ketones

2021 ◽  
Author(s):  
Xin-Xing Wu ◽  
Hao Ye ◽  
Ming Li ◽  
Jianing Qian ◽  
Hong Dai ◽  
...  
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
Selective Synthesis ◽  
Methyl Ketones ◽  
Rapid Access ◽  
Palladium Catalyzed ◽  
Efficient Route

A formal [6 + 1] annulation reaction provides an efficient route enabling rapid access to diverse caprolactams by the double C–C bond formation of the same site from methyl ketones.

Nitric oxide coupling mediated by iron porphyrins: the N–N bond formation step is facilitated by electrons and a proton

2012 ◽  
Vol 48 (72) ◽  
pp. 9041 ◽  
Author(s):  
Jun Yi ◽  
Brian H. Morrow ◽  
Adam L. O. C. Campbell ◽  
Jana K. Shen ◽  
George B. Richter-Addo
Keyword(s):  
Nitric Oxide ◽  
Bond Formation ◽  
Iron Porphyrins ◽  
Formation Step

Sequential Michael addition/retro-Claisen condensation of aromatic β-diketones with α,β-unsaturated esters: an approach to obtain 1,5-ketoesters

2016 ◽  
Vol 14 (8) ◽  
pp. 2390-2394 ◽  
Author(s):  
Gui-Xin Cai ◽  
Jing Wen ◽  
Ting-Ting Lai ◽  
Dan Xie ◽  
Cheng-He Zhou
Keyword(s):  
Michael Addition ◽  
Bond Formation ◽  
One Pot ◽  
Claisen Condensation ◽  
Unsaturated Esters ◽  
Mild Conditions

A K2CO3-catalyzed one-pot protocol involving sequential C–C bond formation and cleavage of aromatic β-diketones with α,β-unsaturated esters is developed to obtain 1,5-ketoesters, proceeding smoothly under mild conditions in up to 98% isolated yield.

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