Ligand/PTC-free intramolecular Heck reaction: synthesis of pyrroloquinoxalines and their evaluation against PDE4/luciferase/oral cancer cell growth in vitro and zebrafish in vivo

2013 ◽  
Vol 11 (39) ◽  
pp. 6680 ◽  
Author(s):  
P. Vijaya Babu ◽  
Soumita Mukherjee ◽  
Girdhar Singh Deora ◽  
Keerthana Sarma Chennubhotla ◽  
Raghavender Medisetti ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Heck Reaction ◽  
Reaction Synthesis ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell ◽  
Intramolecular Heck Reaction

Caffeic acid phenethyl ester upregulates N-myc downstream regulated gene 1 via ERK pathway to inhibit human oral cancer cell growth in vitro and in vivo

2017 ◽  
Vol 61 (9) ◽  
pp. 1600842 ◽  
Author(s):  
Li-Chuan Chung ◽  
Kun-Chun Chiang ◽  
Tsui-Hsia Feng ◽  
Kang-Shuo Chang ◽  
Sung-Ting Chuang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Caffeic Acid ◽  
Cancer Cell ◽  
Caffeic Acid Phenethyl Ester ◽  
Erk Pathway ◽  
Cancer Cell Growth ◽  
Oral Cancer Cell

Dendrimers-delivered short hairpin RNA targeting hTERT inhibits oral cancer cell growth in vitro and in vivo

2011 ◽  
Vol 82 (1) ◽  
pp. 17-23 ◽  
Author(s):  
Xiqiang Liu ◽  
Hongzhang Huang ◽  
Jianguang Wang ◽  
Cheng Wang ◽  
Miao Wang ◽  
...  
Keyword(s):  
Cell Growth ◽  
Oral Cancer ◽  
Cancer Cell ◽  
Short Hairpin Rna ◽  
Cancer Cell Growth ◽  
Hairpin Rna ◽  
Rna Targeting ◽  
Short Hairpin

794: Valproic Acid Inhibits Prostate Cancer Cell Growth in Vitro and in Vivo

2006 ◽  
Vol 175 (4S) ◽  
pp. 257-257
Author(s):  
Jennifer Sung ◽  
Qinghua Xia ◽  
Wasim Chowdhury ◽  
Shabana Shabbeer ◽  
Michael Carducci ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Valproic Acid ◽  
Cell Growth ◽  
Cancer Cell ◽  
Prostate Cancer Cell ◽  
Cancer Cell Growth

scholarly journals Triptolide suppresses oral cancer cell PD-L1 expression in the interferon-γ-modulated microenvironment in vitro, in vivo, and in clinical patients

2021 ◽  
Vol 133 ◽  
pp. 111057
Author(s):  
Chin-Shan Kuo ◽  
Cheng-Yu Yang ◽  
Chih-Kung Lin ◽  
Gu-Jiun Lin ◽  
Huey-Kang Sytwu ◽  
...  
Keyword(s):  
Oral Cancer ◽  
Cancer Cell ◽  
Interferon Γ ◽  
Oral Cancer Cell

scholarly journals HOXB4 inhibits the proliferation and tumorigenesis of cervical cancer cells by downregulating the activity of Wnt/β-catenin signaling pathway

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Dan Lei ◽  
Wen-Ting Yang ◽  
Peng-Sheng Zheng
Keyword(s):  
Cervical Cancer ◽  
Cell Growth ◽  
Signaling Pathway ◽  
Cancer Cell ◽  
Tumor Formation ◽  
Cervical Cancer Cell ◽  
Cancer Cell Growth ◽  
Bioinformatics Analyses

AbstractHomeobox B4 (HOXB4), which belongs to the homeobox (HOX) family, possesses transcription factor activity and has a crucial role in stem cell self-renewal and tumorigenesis. However, its biological function and exact mechanism in cervical cancer remain unknown. Here, we found that HOXB4 was markedly downregulated in cervical cancer. We demonstrated that HOXB4 obviously suppressed cervical cancer cell proliferation and tumorigenic potential in nude mice. Additionally, HOXB4-induced cell cycle arrest at the transition from the G0/G1 phase to the S phase. Conversely, loss of HOXB4 promoted cervical cancer cell growth both in vitro and in vivo. Bioinformatics analyses and mechanistic studies revealed that HOXB4 inhibited the activity of the Wnt/β-catenin signaling pathway by direct transcriptional repression of β-catenin. Furthermore, β-catenin re-expression rescued HOXB4-induced cervical cancer cell defects. Taken together, these findings suggested that HOXB4 directly transcriptional repressed β-catenin and subsequently inactivated the Wnt/β-catenin signaling pathway, leading to significant inhibition of cervical cancer cell growth and tumor formation.

scholarly journals Deferasirox, an oral iron chelator, with gemcitabine synergistically inhibits pancreatic cancer cell growth in vitro and in vivo

Oncotarget ◽  
2018 ◽  
Vol 9 (47) ◽  
pp. 28434-28444 ◽  
Author(s):  
Shuhei Shinoda ◽  
Seiji Kaino ◽  
Shogo Amano ◽  
Hirofumi Harima ◽  
Toshihiko Matsumoto ◽  
...  
Keyword(s):  
Pancreatic Cancer ◽  
Cell Growth ◽  
Cancer Cell ◽  
Pancreatic Cancer Cell ◽  
Iron Chelator ◽  
Oral Iron ◽  
Cancer Cell Growth ◽  
Oral Iron Chelator
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