Doubly prenylated tryptamines: cytotoxicity, antimicrobial activity and cyclisation to the marine natural product flustramine A

2013 ◽  
Vol 11 (36) ◽  
pp. 6119 ◽  
Author(s):  
Santosh Kumar Adla ◽  
Florenz Sasse ◽  
Gerhard Kelter ◽  
Heinz-Herbert Fiebig ◽  
Thomas Lindel
Keyword(s):  
Antimicrobial Activity ◽  
Natural Product ◽  
Marine Natural Product

A New Sesterterpene Tetronic Acid From an Australian Marine Sponge, Psammocinia sp.

1995 ◽  
Vol 48 (11) ◽  
pp. 1899 ◽  
Author(s):  
L Murray ◽  
H Hamit ◽  
JNA Hooper ◽  
L Hobbs ◽  
RJ Capon
Keyword(s):  
Antimicrobial Activity ◽  
Natural Product ◽  
Marine Sponge ◽  
Spectroscopic Analysis ◽  
Marine Natural Product ◽  
Structural Isomer ◽  
Tetronic Acid ◽  
Spectroscopic Characteristics

A new sesterterpene tetronic acid (5) exhibiting antimicrobial activity has been isolated from an Australian marine sponge, Psammocinia sp., and its structure secured by detailed spectroscopic analysis. The tetronic acid (5) possesses almost identical spectroscopic characteristics to, and is a structural isomer of, the known marine natural product (6) previously reported from an Australian sponge.

Synthesis of Norfijimycin A with Activity against Mycobacterium tuberculosis

2017 ◽  
Vol 70 (2) ◽  
pp. 229 ◽  
Author(s):  
Alexander Stoye ◽  
Gayathri Nagalingam ◽  
Warwick J. Britton ◽  
Richard J. Payne
Keyword(s):  
Staphylococcus Aureus ◽  
Antimicrobial Activity ◽  
Mycobacterium Tuberculosis ◽  
Total Synthesis ◽  
Natural Product ◽  
Methicillin Resistant Staphylococcus Aureus ◽  
Marine Natural Product ◽  
Significant Activity ◽  
Methyl Group ◽  
Cyclic Depsipeptide

The total synthesis of norfijimycin A, a simplified analogue of the marine natural product fijimycin A, is described. Fijimycin A is a cyclic depsipeptide that has been shown to possess activity against methicillin-resistant Staphylococcus aureus. The natural product contains a rare N,β-dimethyl leucine unit with unknown stereochemistry at the β-carbon. To evaluate the importance of the β-methyl group for antimicrobial activity, we introduced N-methyl leucine into the natural product scaffold. The resulting norfijimycin A was shown to possess significant activity against Mycobacterium tuberculosis, the etiological agent of tuberculosis.

Progress Toward The Total Synthesis Of The Marine Natural Product Karlotoxin 5

Planta Medica ◽  
2013 ◽  
Vol 79 (10) ◽  
Author(s):  
M Albadry ◽  
Y Zou ◽  
Y Takahashi ◽  
A Waters ◽  
M Hossein ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Natural Product ◽  
Marine Natural Product

Actin-binding Comparisons of the Marine Natural Product Latrunculin B with Natural and Semi-synthetic Latrunculin B Analogs

Planta Medica ◽  
2008 ◽  
Vol 74 (03) ◽  
Author(s):  
JJ Bowling ◽  
PR Daga ◽  
S Odde ◽  
SA Ahmed ◽  
MK Mesbah ◽  
...  
Keyword(s):  
Natural Product ◽  
Marine Natural Product ◽  
Actin Binding ◽  
Latrunculin B

Synthesis and antibacterial activities of marine natural product Ianthelliformisamines and subereamine synthetic analogues

2021 ◽  
pp. 127883
Author(s):  
Shivaji Narayan Khadake ◽  
Shaik Karamathulla ◽  
Tapan Kumar Jena ◽  
Mohan Monisha ◽  
Nikhil Kumar Tuti ◽  
...  
Keyword(s):  
Natural Product ◽  
Antibacterial Activities ◽  
Marine Natural Product ◽  
Synthetic Analogues

Chirality Transfer from a Chiral Primary Alcohol Equivalent Through Allyl Cyanate-to-Isocyanate Rearrangement: Synthesis of (+)-Geranyllinaloisocyanide

Synthesis ◽  
2019 ◽  
Vol 51 (15) ◽  
pp. 2959-2964 ◽  
Author(s):  
Yoshiyasu Ichikawa ◽  
Hirofumi Morimoto ◽  
Toshiya Masuda
Keyword(s):  
Natural Product ◽  
Primary Alcohol ◽  
Marine Natural Product ◽  
Chirality Transfer ◽  
New Approach ◽  
Stereogenic Centers ◽  
Quaternary Stereogenic Centers

A new approach was developed to construct quaternary stereogenic centers bearing nitrogen substituents in an enantioselective manner. The strategy takes advantage of [1,3]-chirality transfer from a chiral primary alcohol equivalent through an allyl cyanate-to-isocyanate rearrangement. This approach was employed in an efficient eight-step synthesis of the marine natural product, (+)-geranyllinaloisocyanide, in 43% overall yield.

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