The uptake mechanism and biocompatibility of graphene quantum dots with human neural stem cells

Nanoscale ◽  
2014 ◽  
Vol 6 (11) ◽  
pp. 5799-5806 ◽  
Author(s):  
Weihu Shang ◽  
Xiaoyan Zhang ◽  
Mo Zhang ◽  
Zetan Fan ◽  
Ying Sun ◽  
...  
Keyword(s):  
Stem Cells ◽  
Quantum Dots ◽  
Neural Stem Cells ◽  
Graphene Quantum Dots ◽  
Uptake Mechanism ◽  
Human Neural Stem Cells ◽  
Endocytosis Pathway

The uptake of GQDs by human neural stem cells via the endocytosis pathway is efficient and biocompatible with hNSCs in vitro.

scholarly journals Immunosuppressants Affect Human Neural Stem Cells In Vitro but Not in an In Vivo Model of Spinal Cord Injury

2013 ◽  
Vol 2 (10) ◽  
pp. 731-744 ◽  
Author(s):  
Christopher J. Sontag ◽  
Hal X. Nguyen ◽  
Noriko Kamei ◽  
Nobuko Uchida ◽  
Aileen J. Anderson ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
In Vivo Model ◽  
Human Neural Stem Cells ◽  
Cord Injury

scholarly journals Icariin promotes cell proliferation and regulates gene expression in human neural stem cells in vitro

2016 ◽  
Vol 14 (2) ◽  
pp. 1316-1322 ◽  
Author(s):  
Pan Yang ◽  
Yun-Qian Guan ◽  
Ya-Li Li ◽  
Li Zhang ◽  
Lan Zhang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Stem Cells ◽  
Cell Proliferation ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells

Genome wide expression analysis of human neural stem cells in vitro

2006 ◽  
Vol 198 (2) ◽  
pp. 593
Author(s):  
D.R. Wakeman ◽  
E.Y. Snyder ◽  
D.E. Redmond ◽  
J.F. Loring ◽  
F.J. Mueller
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Expression Analysis ◽  
Human Neural Stem Cells ◽  
Genome Wide ◽  
Genome Wide Expression

Identification of the gliogenic state of human neural stem cells to optimize in vitro astrocyte differentiation

2021 ◽  
pp. 109284
Author(s):  
Marlen Alisch ◽  
Janis Kerkering ◽  
Tadhg Crowley ◽  
Kamil Rosiewicz ◽  
Friedemann Paul ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells ◽  
Astrocyte Differentiation

Human neural stem cells in vitro. A focus on their isolation and perpetuation

2001 ◽  
Vol 55 (2) ◽  
pp. 91-95 ◽  
Author(s):  
A Villa ◽  
F Javier Rubio ◽  
B Navarro ◽  
C Bueno ◽  
A Martínez-Serrano
Keyword(s):  
Stem Cells ◽  
Neural Stem Cells ◽  
Human Neural Stem Cells

scholarly journals Variation of human neural stem cells generating organizer states in vitro before committing to cortical excitatory or inhibitory neuronal fates

2019 ◽  
Author(s):  
Nicola Micali ◽  
Suel-Kee Kim ◽  
Marcelo Diaz-Bustamante ◽  
Genevieve Stein-O’Brien ◽  
Seungmae Seo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Cerebral Cortex ◽  
Neural Stem Cells ◽  
Cell Imaging ◽  
Lineage Tracing ◽  
Systematic Analysis ◽  
Human Neural Stem Cells ◽  
Signaling Mechanisms ◽  
Human Telencephalon

SUMMARYBetter understanding the progression of neural stem cells (NSCs) in the developing cerebral cortex is important for modeling neurogenesis and defining the pathogenesis of neuropsychiatric disorders. Here we used RNA-sequencing, cell imaging and lineage tracing of mouse and human in vitro NSCs to model the generation of cortical neuronal fates. We show that conserved signaling mechanisms regulate the acute transition from proliferative NSCs to committed glutamatergic excitatory neurons. As human telencephalic NSCs developed from pluripotency in vitro, they first transitioned through organizer states that spatially pattern the cortex before generating glutamatergic precursor fates. NSCs derived from multiple human pluripotent lines varied in these early patterning states leading differentially to dorsal or ventral telencephalic fates. This work furthers systematic analysis of the earliest patterning events that generate the major neuronal trajectories of the human telencephalon.

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