One-step synthesis of water-dispersible ultra-small Fe3O4 nanoparticles as contrast agents for T1 and T2 magnetic resonance imaging

Nanoscale ◽  
2014 ◽  
Vol 6 (5) ◽  
pp. 2953 ◽  
Author(s):  
Guannan Wang ◽  
Xuanjun Zhang ◽  
Andreas Skallberg ◽  
Yaxu Liu ◽  
Zhangjun Hu ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agents ◽  
Fe3o4 Nanoparticles ◽  
Resonance Imaging ◽  
Water Dispersible ◽  
One Step ◽  
T1 And T2

scholarly journals Polyaspartic Acid-Coated Paramagnetic Gadolinium Oxide Nanoparticles as a Dual-Modal T1 and T2 Magnetic Resonance Imaging Contrast Agent

2021 ◽  
Vol 11 (17) ◽  
pp. 8222
Author(s):  
Shanti Marasini ◽  
Huan Yue ◽  
Adibehalsadat Ghazanfari ◽  
Son Long Ho ◽  
Ji Ae Park ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Proton Spin ◽  
Water Proton ◽  
Resonance Imaging ◽  
Polyaspartic Acid ◽  
Mri Contrast ◽  
T1 And T2

Surface-coating polymers contribute to nanoparticle-based magnetic resonance imaging (MRI) contrast agents because they can affect the relaxometric properties of the nanoparticles. In this study, polyaspartic acid (PASA)-coated ultrasmall Gd2O3 nanoparticles with an average particle diameter of 2.0 nm were synthesized using the one-pot polyol method. The synthesized nanoparticles exhibited r1 and r2 of 19.1 and = 53.7 s−1mM−1, respectively, (r1 and r2 are longitudinal and transverse water–proton spin relaxivities, respectively) at 3.0 T MR field, approximately 5 and 10 times higher than those of commercial Gd-chelate contrast agents, respectively. The T1 and T2 MR images could be obtained due to an appreciable r2/r1 ratio of 2.80, indicating their potential as a dual-modal T1 and T2 MRI contrast agent.

scholarly journals A New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite

2019 ◽  
Author(s):  
L Zareei ◽  
B Divband ◽  
A Mesbahi ◽  
M Khatamian ◽  
A Kiani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Particle Diameter ◽  
Average Particle ◽  
Relaxation Rates ◽  
Resonance Imaging ◽  
T1 And T2

Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was synthesized. MTT assay was used to consider the nanocomposite safety for cell culture. The T1 and T2 relaxation times were measured using a 1.5 Tesla clinical MRI scanner. Then the corresponding relaxivities were determined.Results: The average particle diameter of the nanocomposite was 50 to 100 nm based on scanning electron microscope (SEM) image. A linear relationship between relaxation rates and the Fe concentration of the nanocomposite was obtained. The T1 and T2 relaxivities of the nanocomposite were calculated 5.413 and 1092.1 mM-1.s-1, respectively which led to the T2/T1 relaxivity ratioof 201.75.Conclusion: The high T2/T1 relaxivity ratio of the iron oxide–4A nanocomposite confirms it’s potential to act as a T2 contrast agent.

scholarly journals A New Potential Contrast Agent for Magnetic Resonance Imaging: Iron Oxide-4A Nanocomposite

2019 ◽  
Vol 9 (2Apr) ◽  
Author(s):  
L Zareei ◽  
B Divband ◽  
A Mesbahi ◽  
M Khatamian ◽  
A Kiani ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Iron Oxide ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Particle Diameter ◽  
Average Particle ◽  
Relaxation Rates ◽  
Resonance Imaging ◽  
T1 And T2

Background: Magnetic resonance imaging (MRI) contrast agents have an important role to differentiate healthy and diseased tissues. Access and design new contrast agents for the optimal use of MRI are necessary. This study aims to evaluate iron oxide–4A nanocomposite ability to act as a magnetic resonance imaging contrast agent.Materials and Methods: Iron oxide–4A nanocomposite (F4A) was synthesized. MTT assay was used to consider the nanocomposite safety for cell culture. The T1 and T2 relaxation times were measured using a 1.5 Tesla clinical MRI scanner. Then the corresponding relaxivities were determined.Results: The average particle diameter of the nanocomposite was 50 to 100 nm based on scanning electron microscope (SEM) image. A linear relationship between relaxation rates and the Fe concentration of the nanocomposite was obtained. The T1 and T2 relaxivities of the nanocomposite were calculated 5.413 and 1092.1 mM-1.s-1, respectively which led to the T2/T1 relaxivity ratioof 201.75.Conclusion: The high T2/T1 relaxivity ratio of the iron oxide–4A nanocomposite confirms it’s potential to act as a T2 contrast agent.

Supramolecular Enhancement of Aminoxyl ORCA Contrast Agents

2019 ◽  
Author(s):  
Hamilton Lee ◽  
Jenica Lumata ◽  
Michael A. Luzuriaga ◽  
Candace Benjamin ◽  
Olivia Brohlin ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Side Effects ◽  
Magnetic Resonance ◽  
Tobacco Mosaic Virus ◽  
Contrast Agents ◽  
Single Molecule ◽  
Organic Radical ◽  
Resonance Imaging ◽  
Physiological Conditions

<div><div><div><p>Many contrast agents for magnetic resonance imaging are based on gadolinium, however side effects limit their use in some patients. Organic radical contrast agents (ORCAs) are potential alternatives, but are reduced rapidly in physiological conditions and have low relaxivities as single molecule contrast agents. Herein, we use a supramolecular strategy where cucurbit[8]uril binds with nanomolar affinities to ORCAs and protects them against biological reductants to create a stable radical in vivo. We further over came the weak contrast by conjugating this complex on the surface of a self-assembled biomacromolecule derived from the tobacco mosaic virus.</p></div></div></div>

scholarly journals Magnetic resonance thermometry using a GdIII-based contrast agent

2021 ◽  
Vol 57 (14) ◽  
pp. 1770-1773
Author(s):  
S. A. Amali S. Subasinghe ◽  
Jonathan Romero ◽  
Cassandra L. Ward ◽  
Matthew D. Bailey ◽  
Donna R. Zehner ◽  
...  
Keyword(s):  
Magnetic Resonance Imaging ◽  
Magnetic Resonance ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Resonance Imaging ◽  
Magnetic Resonance Thermometry

The complexes described here serve as contrast agents for magnetic resonance imaging thermometry.

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