scholarly journals 21st Century natural product research and drug development and traditional medicines

2013 ◽  
Vol 30 (4) ◽  
pp. 584 ◽  
Author(s):  
Linh T. Ngo ◽  
Joseph I. Okogun ◽  
William R. Folk
Keyword(s):  
Drug Development ◽  
Natural Product ◽  
21St Century ◽  
Traditional Medicines ◽  
Natural Product Research

Opportunities for natural products in 21st century antibiotic discovery

2017 ◽  
Vol 34 (7) ◽  
pp. 694-701 ◽  
Author(s):  
Gerard D. Wright
Keyword(s):  
Natural Products ◽  
Natural Product ◽  
21St Century ◽  
New Drugs ◽  
Natural Product Research ◽  
Antibiotic Discovery

Natural product research is poised to regain prominence in delivering new drugs to solve the antibiotic crisis.

Application of Advanced Technologies in Natural Product Research: A Review with Special Emphasis on ADMET Profiling

2020 ◽  
Vol 21 (10) ◽  
pp. 751-767
Author(s):  
Pobitra Borah ◽  
Sangeeta Hazarika ◽  
Satyendra Deka ◽  
Katharigatta N. Venugopala ◽  
Anroop B. Nair ◽  
...  
Keyword(s):  
Drug Discovery ◽  
Natural Product ◽  
Dynamic Range ◽  
Early Stage ◽  
Attrition Rate ◽  
Drug Candidates ◽  
Advanced Technologies ◽  
Natural Product Research ◽  
The Status ◽  
Safety Parameters

The successful conversion of natural products (NPs) into lead compounds and novel pharmacophores has emboldened the researchers to harness the drug discovery process with a lot more enthusiasm. However, forfeit of bioactive NPs resulting from an overabundance of metabolites and their wide dynamic range have created the bottleneck in NP researches. Similarly, the existence of multidimensional challenges, including the evaluation of pharmacokinetics, pharmacodynamics, and safety parameters, has been a concerning issue. Advancement of technology has brought the evolution of traditional natural product researches into the computer-based assessment exhibiting pretentious remarks about their efficiency in drug discovery. The early attention to the quality of the NPs may reduce the attrition rate of drug candidates by parallel assessment of ADMET profiling. This article reviews the status, challenges, opportunities, and integration of advanced technologies in natural product research. Indeed, emphasis will be laid on the current and futuristic direction towards the application of newer technologies in early-stage ADMET profiling of bioactive moieties from the natural sources. It can be expected that combinatorial approaches in ADMET profiling will fortify the natural product-based drug discovery in the near future.

scholarly journals Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research

2019 ◽  
Vol 36 (1) ◽  
pp. 248-249 ◽  
Author(s):  
James B. McAlpine ◽  
Shao-Nong Chen ◽  
Andrei Kutateladze ◽  
John B. MacMillan ◽  
Giovanni Appendino ◽  
...  
Keyword(s):  
Natural Product ◽  
Nmr Data ◽  
Natural Product Research

Correction for ‘The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research’ by James B. McAlpine et al., Nat. Prod. Rep., 2018, DOI: 10.1039/c7np00064b.

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