Design, synthesis and biological evaluation of novel ligustrazinylated derivatives as potent cardiovascular agents

MedChemComm ◽  
2013 ◽  
Vol 4 (5) ◽  
pp. 827-832 ◽  
Author(s):  
Hongfei Chen ◽  
Guoning Li ◽  
Peng Zhan ◽  
Xiuli Guo ◽  
Qian Ding ◽  
...  
Keyword(s):  
Platelet Aggregation ◽  
Protective Effect ◽  
Biological Evaluation ◽  
Cardiovascular Agents ◽  
Design Synthesis ◽  
Platelet Aggregation Inhibition ◽  
Aggregation Inhibition ◽  
Synthesis And Biological Evaluation

A series of novel ligustrazinylated derivatives was designed, synthesized and evaluated for their platelet aggregation inhibition and protective effect on injured ECV-304 cells.

The design, synthesis and biological evaluation of pro-EGCG derivatives as novel anti-vitiligo agents

RSC Advances ◽  
2016 ◽  
Vol 6 (108) ◽  
pp. 106308-106315 ◽  
Author(s):  
Siyu Wang ◽  
Rong Jin ◽  
Ruiquan Wang ◽  
Yongzhou Hu ◽  
Xiaowu Dong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Potential Application ◽  
Cell Damage ◽  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation

A series of prodrugs of EGCG derivatives were designed, synthesized, and the protective effect on melanocytes against H2O2-induced cell damage were extensively evaluated, demonstrating the potential application value of them in anti-vitiligo treatment.

Design, Synthesis and Biological Evaluation of Hybrid Molecules Containing Conjugated Styryl Ketone and α-Bromoacryloyl Moieties

2012 ◽  
Vol 9 (2) ◽  
pp. 140-152 ◽  
Author(s):  
Romeo Romagnoli ◽  
Pier Giovanni Baraldi ◽  
Olga Cruz-Lopez ◽  
Maria Kimatrai Salvador ◽  
Delia Preti ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Hybrid Molecules ◽  
Synthesis And Biological Evaluation

Design, Synthesis and Biological Evaluation of Novel Aminosaccharide Derivatives of Combretastatin A-4

2013 ◽  
Vol 10 (10) ◽  
pp. 935-941
Author(s):  
Yan Tang ◽  
Zhewei Tu ◽  
Jing Sun ◽  
Xiong Zhu ◽  
Kun Liu ◽  
...  
Keyword(s):  
Biological Evaluation ◽  
Design Synthesis ◽  
Synthesis And Biological Evaluation ◽  
Derivatives Of
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