Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors

Jie Zhou; Mingyu Ba; Bo Wang; Haibo Zhou; Jianbo Bie; Decai Fu; Yingli Cao; Bailing Xu; Ying Guo

doi:10.1039/c3md00337j

Synthesis and biological evaluation of novel quinoxalinone-based HIV-1 reverse transcriptase inhibitors

MedChemComm ◽

10.1039/c3md00337j ◽

2014 ◽

Vol 5 (4) ◽

pp. 441-444 ◽

Cited By ~ 6

Author(s):

Jie Zhou ◽

Mingyu Ba ◽

Bo Wang ◽

Haibo Zhou ◽

Jianbo Bie ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Quinoxalinone Derivatives ◽

Synthesis And Biological Evaluation ◽

Anti Hiv ◽

Hiv 1

A series of novel quinoxalinone derivatives were identified as potent anti-HIV-1 agents with IC50 values at 10−8 μmol L−1 level.

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ChemInform Abstract: Synthesis and Biological Evaluation of Certain Alkenyldiarylmethanes as Anti-HIV-1 Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors.

ChemInform ◽

10.1002/chin.199648103 ◽

2010 ◽

Vol 27 (48) ◽

pp. no-no

Author(s):

M. CUSHMAN ◽

W. M. GOLEBIEWSKI ◽

L. GRAHAM ◽

J. A. TURPIN ◽

W. G. RICE ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Anti Hiv ◽

Hiv 1

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Synthesis and Biological Evaluation of Certain Alkenyldiarylmethanes as Anti-HIV-1 Agents Which Act as Non-Nucleoside Reverse Transcriptase Inhibitors

Journal of Medicinal Chemistry ◽

10.1021/jm960082v ◽

1996 ◽

Vol 39 (16) ◽

pp. 3217-3227 ◽

Cited By ~ 27

Author(s):

Mark Cushman ◽

W. Marek Golebiewski ◽

Lisa Graham ◽

Jim A. Turpin ◽

William G. Rice ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Anti Hiv ◽

Hiv 1

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Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of N4-(hetero)arylsulfonylquinoxalinones as HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.02.039 ◽

2009 ◽

Vol 17 (7) ◽

pp. 2767-2774 ◽

Cited By ~ 23

Author(s):

Bailing Xu ◽

Yan Sun ◽

Ying Guo ◽

Yingli Cao ◽

Tao Yu

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and Biological Evaluation of Alkenyldiarylmethane HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors That Possess Increased Hydrolytic Stability

Journal of Medicinal Chemistry ◽

10.1021/jm070382k ◽

2007 ◽

Vol 50 (20) ◽

pp. 4854-4867 ◽

Cited By ~ 17

Author(s):

Matthew D. Cullen ◽

Bo-Liang Deng ◽

Tracy L. Hartman ◽

Karen M. Watson ◽

Robert W. Buckheit, ◽

...

Keyword(s):

Reverse Transcriptase ◽

Hydrolytic Stability ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, discovery, modelling, synthesis, and biological evaluation of novel and small, low toxicity s-triazine derivatives as HIV-1 non-nucleoside reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.04.018 ◽

2016 ◽

Vol 24 (11) ◽

pp. 2519-2529 ◽

Cited By ~ 13

Author(s):

Birgit Viira ◽

Anastasia Selyutina ◽

Alfonso T. García-Sosa ◽

Maarit Karonen ◽

Jari Sinkkonen ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Triazine Derivatives ◽

Low Toxicity ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Synthesis and biological evaluation of imidazole thioacetanilides as novel non-nucleoside HIV-1 reverse transcriptase inhibitors

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2009.07.028 ◽

2009 ◽

Vol 17 (16) ◽

pp. 5775-5781 ◽

Cited By ~ 35

Author(s):

Peng Zhan ◽

Xinyong Liu ◽

Junjie Zhu ◽

Zengjun Fang ◽

Zhenyu Li ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation

Il Farmaco ◽

10.1016/j.farmac.2005.03.005 ◽

2005 ◽

Vol 60 (5) ◽

pp. 377-384 ◽

Cited By ~ 27

Author(s):

D. Sriram ◽

T.R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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