Novel radioiodinated 1,3,4-oxadiazole derivatives with improved in vivo properties for SPECT imaging of β-amyloid plaques

MedChemComm ◽  
2014 ◽  
Vol 5 (1) ◽  
pp. 82-85 ◽  
Author(s):  
Hiroyuki Watanabe ◽  
Masahiro Ono ◽  
Hiroyuki Kimura ◽  
Kenji Matsumura ◽  
Masashi Yoshimura ◽  
...  
Keyword(s):  
Amyloid Plaques ◽  
Spect Imaging ◽  
Oxadiazole Derivatives ◽  
Β Amyloid

scholarly journals SPECT Imaging Agents for Detecting Cerebral β-Amyloid Plaques

2011 ◽  
Vol 2011 ◽  
pp. 1-12 ◽  
Author(s):  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Brain Tissue ◽  
Quantitative Evaluation ◽  
Amyloid Plaques ◽  
Current Situation ◽  
Definitive Diagnosis ◽  
Spect Imaging ◽  
Amyloid Aβ ◽  
Β Amyloid ◽  
The Brain

The development of radiotracers for use in vivo to image β-amyloid (Aβ) plaques in cases of Alzheimer's disease (AD) is an important, active area of research. The presence of Aβ aggregates in the brain is generally accepted as a hallmark of AD. Since the only definitive diagnosis of AD is by postmortem staining of affected brain tissue, the development of techniques which enable one to image Aβ plaques in vivo has been strongly desired. Furthermore, the quantitative evaluation of Aβ plaques in the brain could facilitate evaluation of the efficacy of antiamyloid therapies currently under development. This paper reviews the current situation in the development of agents for SPECT-based imaging of Aβ plaques in Alzheimer's brains.

Novel quinoxaline derivatives for in vivo imaging of β-amyloid plaques in the brain

2011 ◽  
Vol 21 (14) ◽  
pp. 4193-4196 ◽  
Author(s):  
Mengchao Cui ◽  
Masahiro Ono ◽  
Hiroyuki Kimura ◽  
Boli Liu ◽  
Hideo Saji
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Quinoxaline Derivatives ◽  
Β Amyloid ◽  
The Brain

scholarly journals Imaging of β-amyloid plaques by near infrared fluorescent tracers: a new frontier for chemical neuroscience

2015 ◽  
Vol 44 (7) ◽  
pp. 1807-1819 ◽  
Author(s):  
Matteo Staderini ◽  
María Antonia Martín ◽  
Maria Laura Bolognesi ◽  
J. Carlos Menéndez
Keyword(s):  
Near Infrared ◽  
Amyloid Plaques ◽  
Fluorescent Tracers ◽  
Non Invasive ◽  
Nir Imaging ◽  
New Frontier ◽  
Invasive Method ◽  
Β Amyloid

Near infrared (NIR) imaging is a promising and non-invasive method to visualize amyloid plaquesin vivo.

scholarly journals Development of Novel 123I-Labeled Pyridyl Benzofuran Derivatives for SPECT Imaging of β-Amyloid Plaques in Alzheimer’s Disease

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e74104 ◽  
Author(s):  
Masahiro Ono ◽  
Yan Cheng ◽  
Hiroyuki Kimura ◽  
Hiroyuki Watanabe ◽  
Kenji Matsumura ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Amyloid Plaques ◽  
Spect Imaging ◽  
Β Amyloid

Oh, the places you’ll go!

2018 ◽  
Vol 10 (425) ◽  
pp. eaar7522
Author(s):  
Jennifer A. Philips
Keyword(s):  
Stem Cells ◽  
Amyloid Plaques ◽  
Selection Strategy ◽  
In Vivo Selection ◽  
Β Amyloid ◽  
The Brain

An in vivo selection strategy identifies an antibody that induces stem cells to differentiate into microglia-like cells, migrate to the brain, and reduce β-amyloid plaques in mice.

Recent advances in molecular imaging probes for β-amyloid plaques

MedChemComm ◽  
2015 ◽  
Vol 6 (3) ◽  
pp. 391-402 ◽  
Author(s):  
Masahiro Ono ◽  
Hideo Saji
Keyword(s):  
Molecular Imaging ◽  
Optical Imaging ◽  
Amyloid Plaques ◽  
Recent Advances ◽  
Molecular Imaging Probes ◽  
Imaging Probes ◽  
Β Amyloid ◽  
The Brain

We review recent advances in our development of molecular imaging probes for PET, SPECT, and optical imaging for in vivo detection of β-amyloid plaques in the brain.

Radioiodinated Flavones for in Vivo Imaging of β-Amyloid Plaques in the Brain

2005 ◽  
Vol 48 (23) ◽  
pp. 7253-7260 ◽  
Author(s):  
Masahiro Ono ◽  
Naoko Yoshida ◽  
Kenichi Ishibashi ◽  
Mamoru Haratake ◽  
Yasushi Arano ◽  
...  
Keyword(s):  
In Vivo Imaging ◽  
Amyloid Plaques ◽  
Β Amyloid ◽  
The Brain

scholarly journals Structure–Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of β-Amyloid Plaques

2013 ◽  
Vol 4 (7) ◽  
pp. 596-600 ◽  
Author(s):  
Masashi Yoshimura ◽  
Masahiro Ono ◽  
Kenji Matsumura ◽  
Hiroyuki Watanabe ◽  
Hiroyuki Kimura ◽  
...  
Keyword(s):  
Pet Imaging ◽  
Amyloid Plaques ◽  
In Vivo Evaluation ◽  
Structure Activity Relationships ◽  
Structure Activity ◽  
Quinoxaline Derivatives ◽  
Β Amyloid

Novel Radioiodinated Aurones as Probes for SPECT Imaging of β-Amyloid Plaques in the Brain

2009 ◽  
Vol 20 (1) ◽  
pp. 95-101 ◽  
Author(s):  
Yoshifumi Maya ◽  
Masahiro Ono ◽  
Hiroyuki Watanabe ◽  
Mamoru Haratake ◽  
Hideo Saji ◽  
...  
Keyword(s):  
Amyloid Plaques ◽  
Spect Imaging ◽  
Β Amyloid ◽  
The Brain
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