Transcriptional profiling and co-expression network analysis identifies potential biomarkers to differentiate chronic hepatitis B and the caused cirrhosis

2014 ◽  
Vol 10 (5) ◽  
pp. 1117-1125 ◽  
Author(s):  
Yi-Yu Lu ◽  
Qi-Long Chen ◽  
Yan Guan ◽  
Zhi-Zhong Guo ◽  
Hui Zhang ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Network Analysis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
Transcriptional Profiling ◽  
Potential Biomarkers

scholarly journals Bayesian analysis of cytokines and chemokine identifies immune pathways of HBsAg loss during chronic hepatitis B treatment

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Sriram Narayanan ◽  
Veonice Bijin Au ◽  
Atefeh Khakpoor ◽  
Cheng Yan ◽  
Patricia J. Ahl ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
T Cell ◽  
Network Analysis ◽  
Hepatitis B ◽  
Chronic Hepatitis B ◽  
T Cell Activation ◽  
Cell Activation ◽  
Hbsag Loss ◽  
Immune Pathways

AbstractOur objective was to examine differences in cytokine/chemokine response in chronic hepatitis B(CHB) patients to understand the immune mechanism of HBsAg loss (functional cure) during antiviral therapy. We used an unbiased machine learning strategy to unravel the immune pathways in CHB nucleo(t)side analogue-treated patients who achieved HBsAg loss with peg-interferon-α(peg-IFN-α) add-on or switch treatment in a randomised clinical trial. Cytokines/chemokines from plasma were compared between those with/without HBsAg loss, at baseline, before and after HBsAg loss. Peg-IFN-α treatment resulted in higher levels of IL-27, IL-12p70, IL-18, IL-13, IL-4, IL-22 and GM-CSF prior to HBsAg loss. Probabilistic network analysis of cytokines, chemokines and soluble factors suggested a dynamic dendritic cell driven NK and T cell immune response associated with HBsAg loss. Bayesian network analysis showed a dominant myeloid-driven type 1 inflammatory response with a MIG and I-TAC central module contributing to HBsAg loss in the add-on arm. In the switch arm, HBsAg loss was associated with a T cell activation module exemplified by high levels of CD40L suggesting T cell activation. Our findings show that more than one immune pathway to HBsAg loss was found with peg-IFN-α therapy; by myeloid-driven Type 1 response in one instance, and T cell activation in the other.

scholarly journals Serum Glycopatterns as Novel Potential Biomarkers for Diagnosis of Acute-on-Chronic Hepatitis B Liver Failure

2017 ◽  
Vol 7 (1) ◽  
Author(s):  
Yaogang Zhong ◽  
Yonghong Guo ◽  
Xiawei Liu ◽  
Jiaxu Zhang ◽  
Tianran Ma ◽  
...  
Keyword(s):  
Chronic Hepatitis ◽  
Hepatitis B ◽  
Liver Failure ◽  
Chronic Hepatitis B ◽  
Potential Biomarkers
Sign in / Sign up

Export Citation Format

Share Document