scholarly journals Integrated lab-on-chip biosensing systems based on magnetic particle actuation – a comprehensive review

Lab on a Chip ◽  
2014 ◽  
Vol 14 (12) ◽  
pp. 1966-1986 ◽  
Author(s):  
Alexander van Reenen ◽  
Arthur M. de Jong ◽  
Jaap M. J. den Toonder ◽  
Menno W. J. Prins
Keyword(s):  
Magnetic Fields ◽  
Magnetic Particles ◽  
Magnetic Particle ◽  
Comprehensive Review ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
On Chip

A review on the use of magnetic particles that are actuated by magnetic fields for integrated lab-on-chip diagnostic assays.

scholarly journals Rotating magnetic particles for lab-on-chip applications – a comprehensive review

Lab on a Chip ◽  
2019 ◽  
Vol 19 (6) ◽  
pp. 919-933 ◽  
Author(s):  
C. P. Moerland ◽  
L. J. van IJzendoorn ◽  
M. W. J. Prins
Keyword(s):  
Magnetic Fields ◽  
Magnetic Particles ◽  
High Surface ◽  
Volume Ratio ◽  
Comprehensive Review ◽  
Lab On Chip ◽  
On Chip

Magnetic particles are widely used in lab-on-chip and biosensing applications, because they have a high surface-to-volume ratio, they can be actuated with magnetic fields and many biofunctionalization options are available. This review focuses on the use of rotating magnetic particles for lab-on-chip applications.

scholarly journals Optical Imaging of Magnetic Particle Cluster Oscillation and Rotation in Glycerol

2021 ◽  
Vol 7 (5) ◽  
pp. 82
Author(s):  
River Gassen ◽  
Dennis Thompkins ◽  
Austin Routt ◽  
Philippe Jones ◽  
Meghan Smith ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Magnetic Fields ◽  
Magnetic Particles ◽  
Magnetic Particle ◽  
Barium Hexaferrite ◽  
Optical Microscope ◽  
Simplified Model ◽  
Particle Cluster ◽  
Average Deviation ◽  
Cross Sectional

Magnetic particles have been evaluated for their biomedical applications as a drug delivery system to treat asthma and other lung diseases. In this study, ferromagnetic barium hexaferrite (BaFe12O19) and iron oxide (Fe3O4) particles were suspended in water or glycerol, as glycerol can be 1000 times more viscous than water. The particle concentration was 2.50 mg/mL for BaFe12O19 particle clusters and 1.00 mg/mL for Fe3O4 particle clusters. The magnetic particle cluster cross-sectional area ranged from 15 to 1000 μμm2, and the particle cluster diameter ranged from 5 to 45 μμm. The magnetic particle clusters were exposed to oscillating or rotating magnetic fields and imaged with an optical microscope. The oscillation frequency of the applied magnetic fields, which was created by homemade wire spools inserted into an optical microscope, ranged from 10 to 180 Hz. The magnetic field magnitudes varied from 0.25 to 9 mT. The minimum magnetic field required for particle cluster rotation or oscillation in glycerol was experimentally measured at different frequencies. The results are in qualitative agreement with a simplified model for single-domain magnetic particles, with an average deviation from the model of 1.7 ± 1.3. The observed difference may be accounted for by the fact that our simplified model does not include effects on particle cluster motion caused by randomly oriented domains in multi-domain magnetic particle clusters, irregular particle cluster size, or magnetic anisotropy, among other effects.

Point-of-Care Systems for Rapid DNA Quantification in Oncology

2008 ◽  
Vol 94 (2) ◽  
pp. 216-225 ◽  
Author(s):  
Marco Bianchessi ◽  
Sarah Burgarella ◽  
Marco Cereda
Keyword(s):  
Point Of Care ◽  
Low Cost ◽  
Semiconductor Industry ◽  
Point Of Care Testing ◽  
Lab On Chip ◽  
Diagnostic Assays ◽  
Care Systems ◽  
Point Of Care Systems ◽  
The Common ◽  
On Chip

The development of new powerful applications and the improvement in fabrication techniques are promising an explosive growth in lab-on-chip use in the upcoming future. As the demand reaches significant levels, the semiconductor industry may enter in the field, bringing its capability to produce complex devices in large volumes, high quality and low cost. The lab-on-chip concept, when applied to medicine, leads to the point-of-care concept, where simple, compact and cheap instruments allow diagnostic assays to be performed quickly by untrained personnel directly at the patient's side. In this paper, some practical and economical considerations are made to support the advantages of point-of-care testing. A series of promising technologies developed by STMicroelectronics on lab-on-chips is also presented, mature enough to enter in the common medical practice. The possible use of these techniques for cancer research, diagnosis and treatment are illustrated together with the benefits offered by their implementation in point-of-care testing.

Lab-on-Chip Microfluidics System for Single Cell Mass Measurement: A Comprehensive Review

2014 ◽  
Vol 69 (8) ◽  
Author(s):  
Md. Habibur Rahman ◽  
Mohd Ridzuan Ahmad
Keyword(s):  
Single Cell ◽  
Measurement System ◽  
Single Cell Analysis ◽  
Mass Measurement ◽  
Cell Mass ◽  
Comprehensive Review ◽  
Lab On Chip ◽  
Mass Sensitivity ◽  
Cantilever Arrays ◽  
On Chip

Single cell mass (SCM) is one of the intrinsic properties of cell and is a vital part of single cell analysis (SCA). To date, a myriad numbers of works has been successfully reported for single cell mass measurement but the reported information are scattered, consequently a comprehensive review becomes mandatory to bring them together. Lab-on-chip microfluidics system integrated with micro-resonator provided an excellent platform to measure single cell mass directly (in presence of cells). On-chip microfluidics system like suspended micro channel resonator (SMR) was reported for non-adherent single yeast cell mass while ‘living cantilever arrays’ (LCA) was proposed to measure adherent HeLa cell mass. On the other hand, cantilever based resonant mass measurement system has non-uniform mass sensitivity; this issue has been overcome by pedestal mass measurement system (PMMS). PMMS has a unique geometrical structure that provided uniform mass sensitivity to the sensing surface. Moreover, we presented a comprehensive discussion of each of the available methods of SCM elaborating the sensing mechanism, geometry of the sensor and governing equations. It is hoped that, information presented in this comprehensive review paper will be a valuable source for the single cell mass analysers and biological researchers.  

Finite Element Analysis and Preliminary Fabrication of Flexible Membrane with Embedded Magnetic Nanoparticles

2014 ◽  
Vol 1024 ◽  
pp. 147-150
Author(s):  
Yunas Jumril ◽  
Mohd. Said Muzalifah ◽  
Yeop Majlis Burhanuddin ◽  
Badariah Bais
Keyword(s):  
Magnetic Particles ◽  
Polymer Membrane ◽  
Membrane Properties ◽  
Element Analysis ◽  
Flexible Membrane ◽  
Lab On Chip ◽  
Membrane Deformation ◽  
Flexible Polymer ◽  
Embedded Particles ◽  
On Chip

In this study, mechanical characteristic of flexible polymer membrane embedded with nanomagnetic particles is analyzed using COMSOL Multiphysics 4.3. The mechanical properties of the membrane is studied by considering the magnetic particles as matrix structures embedded inside the polymer. The target of this work is to realize a new type of magnetic actuator that is able to generate a strong magnetic field and has large mechanical deformation capability as well. On the other hand, the flexible membrane properties should be optically paternable and display very high magnetic sensitivity. Therefore the study is focused not only to analyze the membrane properties but also the technique to fabricate the membrane for MEMS actuator. In this work, the magnetic force acting on the membrane, the length and height of the membrane, and the total volume of Ni particles were set to be constant. A good agreement between simulation and calculation on maximum membrane deformation without particle content was observed. It is shown that by having Ni particles embedded in polymer membrane, the deformation capability was greatly increased up to 30.9 μm. Therefore this study has proven that the smaller size of the magnetic particles with the planar structure arrangement and homogenous distribution of embedded particles can enhance larger membrane deformation. The fabrication concept of the membrane and material synthesis are also introduced. The results obtained in this study will have an important role in the development of electromagnetic actuator for fluids injector integrated in Lab-on-Chip system.

On chip magnetic actuator for batch-mode dynamic manipulation of magnetic particles in compact lab-on-chip

2011 ◽  
Vol 160 (1) ◽  
pp. 1520-1528 ◽  
Author(s):  
Rémy Fulcrand ◽  
Aurélien Bancaud ◽  
Christophe Escriba ◽  
Qihao He ◽  
Samuel Charlot ◽  
...  
Keyword(s):  
Magnetic Particles ◽  
Magnetic Actuator ◽  
Batch Mode ◽  
Lab On Chip ◽  
On Chip ◽  
Dynamic Manipulation

scholarly journals A Lab‐On‐chip Tool for Rapid, Quantitative, and Stage‐selective Diagnosis of Malaria

2021 ◽  
pp. 2004101
Author(s):  
Marco Giacometti ◽  
Francesca Milesi ◽  
Pietro Lorenzo Coppadoro ◽  
Alberto Rizzo ◽  
Federico Fagiani ◽  
...  
Keyword(s):  
Lab On Chip ◽  
On Chip

scholarly journals Integrated Magnetohydrodynamic Pump with Magnetic Composite Substrate and Laser-Induced Graphene Electrodes

Polymers ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1113
Author(s):  
Mohammed Asadullah Khan ◽  
Jürgen Kosel
Keyword(s):  
Magnetic Flux ◽  
Flow Rate ◽  
Magnetic Composite ◽  
Propulsive Force ◽  
Closed Channel ◽  
Lab On Chip ◽  
Composite Substrate ◽  
On Chip ◽  
High Level ◽  
Moving Parts

An integrated polymer-based magnetohydrodynamic (MHD) pump that can actuate saline fluids in closed-channel devices is presented. MHD pumps are attractive for lab-on-chip applications, due to their ability to provide high propulsive force without any moving parts. Unlike other MHD devices, a high level of integration is demonstrated by incorporating both laser-induced graphene (LIG) electrodes as well as a NdFeB magnetic-flux source in the NdFeB-polydimethylsiloxane permanent magnetic composite substrate. The effects of transferring the LIG film from polyimide to the magnetic composite substrate were studied. Operation of the integrated magneto hydrodynamic pump without disruptive bubbles was achieved. In the studied case, the pump produces a flow rate of 28.1 µL/min. while consuming ~1 mW power.

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