Determination of toxic elements in tricyclic active pharmaceutical ingredients by ICP-MS: a critical study of digestion methods

2014 ◽  
Vol 29 (2) ◽  
pp. 352 ◽  
Author(s):  
Juliano S. Barin ◽  
Bruna Tischer ◽  
Rochele S. Picoloto ◽  
Fabiane G. Antes ◽  
Fabiana E. B. da Silva ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Critical Study ◽  
Active Pharmaceutical Ingredients ◽  
Pharmaceutical Ingredients ◽  
Icp Ms ◽  
Digestion Methods

scholarly journals Determination of Toxic Elements and Arsenic Species in Salted Foods and Sea Salt by ICP–MS and HPLC–ICP–MS

ACS Omega ◽  
2021 ◽  
Author(s):  
In Min Hwang ◽  
Hee Min Lee ◽  
Hae-Won Lee ◽  
Ji-Hye Jung ◽  
Eun Woo Moon ◽  
...  
Keyword(s):  
Toxic Elements ◽  
Arsenic Species ◽  
Sea Salt ◽  
Icp Ms

Total determination of essential and toxic elements in milk whey by double focusing ICP-MS

2000 ◽  
Vol 15 (2) ◽  
pp. 163-168 ◽  
Author(s):  
Fidel Angel Rivero Martino ◽  
María Luisa Fernández Sánchez ◽  
Alfredo Sanz Medel
Keyword(s):  
Toxic Elements ◽  
Milk Whey ◽  
Icp Ms ◽  
Essential And Toxic Elements ◽  
Double Focusing

Simultaneous Determination of Emtricitabine and Tenofovir disoproxil fumarate in Pharmaceutical Dosage by Reverse Phase High Performance Liquid Chromatography

2021 ◽  
pp. 412-416
Author(s):  
Rajan V. Rele ◽  
Sandip P. Patil
Keyword(s):  
High Performance Liquid Chromatography ◽  
Liquid Chromatography ◽  
Simultaneous Determination ◽  
Tenofovir Disoproxil Fumarate ◽  
High Performance ◽  
Phosphoric Acid Solution ◽  
Active Pharmaceutical Ingredients ◽  
Chromatography Method ◽  
Pharmaceutical Ingredients

A simple, rapid and accurate high performance liquid chromatography method is described for simultaneous determination of emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients. The separation of drug was achieved on Hypersil BDS C18 (150 x 4.6 mm i.d.) with 5 µ particle size column showed most favorable chromatographic pattern over the other columns. The mobile phase consisted of a mixture of buffer and methanol (85:15 % v/v). The buffer was mixtures of 0.1 % (v/v) ortho-phosphoric acid solution adjusted the pH 3.5 with tri-ethyl amine. The detection was carried out at wavelength 260 nm. The mixture of buffer of pH 3.5 and methanol (85:15% v/v) was used as a diluent. The method was validated for system suitability, linearity, accuracy, precision, robustness, stability of sample solution. The method has been successfully used to analyze emtricitabine and tenofovir disoproxil fumarate from active pharmaceutical ingredients.

scholarly journals Determination of Essential and Toxic Elements in Cattle Blood: Serum vs Plasma

Animals ◽  
2019 ◽  
Vol 9 (7) ◽  
pp. 465 ◽  
Author(s):  
Diego Luna ◽  
Marta López-Alonso ◽  
Yolanda Cedeño ◽  
Lucas Rigueira ◽  
Víctor Pereira ◽  
...  
Keyword(s):  
Inductively Coupled Plasma ◽  
Toxic Elements ◽  
Serum Samples ◽  
Element Analysis ◽  
Inductively Coupled ◽  
Icp Ms ◽  
Plasma Mass Spectrometry ◽  
Essential And Toxic Elements ◽  
High Concentrations

This study was designed to evaluate the influence of type of blood sample (serum or plasma) on essential and toxic element analysis in cattle. Paired plasma and serum samples (n = 20) were acid digested, and the concentrations of As, B, Ba, Ca, Cd, Co, Cr, Cu, Fe, Hg, Li, Mg, Mn. Mo, Ni, P, Pb, Sb, Se, Sr and Zn were determined by inductively coupled plasma mass spectrometry (ICP-MS). The study findings indicate that plasma and serum samples appear suitable and interchangeable for the determination of most of the essential and toxic elements in blood in cattle. The only exceptions are Cu and Se, the concentrations of which were significantly lower (40.9 and 29.9% respectively) in serum than in plasma. Some of the Cu in blood samples from bovine ruminants is known to be sequestered during clotting. However, further research on Se in ruminants and other animal species is warranted. Finally, the significantly higher Mn (9.9%) concentrations in serum than in plasma may have been caused by haemolysis of some samples. Special attention should be paid to preventing haemolysis of samples during collection and processing, in order to prevent overestimation of elements present at high concentrations inside erythrocytes (i.e., Fe, Mn and Zn).

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