scholarly journals A microfluidic-based genetic screen to identify microbial virulence factors that inhibit dendritic cell migration

2014 ◽  
Vol 6 (4) ◽  
pp. 438-449 ◽  
Author(s):  
Laura M. McLaughlin ◽  
Hui Xu ◽  
Sarah E. Carden ◽  
Samantha Fisher ◽  
Monique Reyes ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Virulence Factors ◽  
Genetic Screen ◽  
Critical Step ◽  
Dendritic Cell Migration ◽  
Human Immune Response ◽  
Human Immune ◽  
Cell Chemotaxis

A microfluidic-based screen to identify Salmonella genes that impede dendritic cell chemotaxis, a critical step of the human immune response.

Primary human immune response to dendritic cell inoculation in humanized mice

2008 ◽  
Vol 22 (S2) ◽  
pp. 422-422
Author(s):  
Daisy Vanitha John ◽  
Laura Crisa ◽  
Gabrielle Cauvi ◽  
Mohey Eldin El Shikh ◽  
John G Tew ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cell ◽  
Humanized Mice ◽  
Cell Inoculation ◽  
Human Immune Response ◽  
Human Immune

scholarly journals Substance P Release by Sensory Neurons Triggers Dendritic Cell Migration and Initiates the Type-2 Immune Response to Allergens

Immunity ◽  
2020 ◽  
Vol 53 (5) ◽  
pp. 1063-1077.e7 ◽  
Author(s):  
Caroline Perner ◽  
Cameron H. Flayer ◽  
Xueping Zhu ◽  
Pamela A. Aderhold ◽  
Zaynah N.A. Dewan ◽  
...  
Keyword(s):  
Immune Response ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Substance P ◽  
Sensory Neurons ◽  
P Release ◽  
Type 2 Immune Response ◽  
Dendritic Cell Migration ◽  
Substance P Release

scholarly journals Dendritic Cell Trafficking and Antigen Presentation in the Human Immune Response toMycobacterium tuberculosis

2004 ◽  
Vol 173 (1) ◽  
pp. 494-506 ◽  
Author(s):  
Simeone Marino ◽  
Santosh Pawar ◽  
Craig L. Fuller ◽  
Todd A. Reinhart ◽  
JoAnne L. Flynn ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cell ◽  
Antigen Presentation ◽  
Cell Trafficking ◽  
Human Immune Response ◽  
Human Immune ◽  
Dendritic Cell Trafficking

scholarly journals Prostaglandin E2 Inhibits Prostate Cancer Progression by Countervailing Tumor Microenvironment-Induced Impairment of Dendritic Cell Migration through LXRα/CCR7 Pathway

2018 ◽  
Vol 2018 ◽  
pp. 1-8 ◽  
Author(s):  
Kuang Youlin ◽  
He Weiyang ◽  
Liang Simin ◽  
Gou Xin
Keyword(s):  
Prostate Cancer ◽  
Immune Response ◽  
Dendritic Cells ◽  
Cell Migration ◽  
Dendritic Cell ◽  
Tumor Microenvironment ◽  
Cancer Progression ◽  
Prostaglandin E ◽  
Prostate Cancer Progression ◽  
Dendritic Cell Migration

Migration and homing of dendritic cells (DCs) to lymphoid organs are quite crucial for T cell-induced immune response against tumor. However, tumor microenvironment can make some tumor cells escape immune response by impairing DC migration. Prostaglandin E2 (PGE2) plays important roles in initiating and terminating inflammatory responses. In this study, we investigated whether PGE2 could inhibit murine prostate cancer progression by countervailing tumor microenvironment-induced impairment of dendritic cell migration. We found that murine prostate cancer cell line RM-1-conditioned medium impaired chemotactic movement of marrow-derived DCs and splenic cDCs toward CC chemokine receptor-7 (CCR7) ligand CCL19 in vitro and migration to draining lymph gland in vivo. Meanwhile, it also induced LXRα activation and CCR7 inhibition on maturing DCs. However, the treatment of PGE2 rescued this impairment of DC migration with upregulation of CCR7 and inhibition of LXRα. Further, it was observed that PGE2 also increased MMP9 expression and activated Notch1 signaling on DCs. In RM-1-bearing mouse model, PGE2 treatment was identified to inhibit tumor growth and induce more tumor-infiltrating T cells and CD11c dendritic cells in tumor sites. Therefore, our findings may demonstrate a new perspective for therapeutic interventions on prostate cancer immunoescape.

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