Production of reactive oxygen and nitrogen species by light irradiation of a nitrosyl phthalocyanine ruthenium complex as a strategy for cancer treatment

2014 ◽  
Vol 43 (10) ◽  
pp. 4021-4025 ◽  
Author(s):  
Tassiele A. Heinrich ◽  
Antonio Claudio Tedesco ◽  
Jon M. Fukuto ◽  
Roberto Santana da Silva
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Ruthenium Complex ◽  
Reactive Oxygen ◽  
Reduction Process ◽  
Light Irradiation ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Oxygen Formation ◽  
Singlet Oxygen Formation

Nitric oxide (NO) and reactive oxygen species originated from [Ru(pc)(pz)2{Ru(bpy)2(NO)}2](PF6)6(I) have been postulated to act synergistically against cancer cells. NO is released from (I) by the reduction process and singlet oxygen formation by light irradiation at 660 nm.

Plasmonic Enhancement of Nitric Oxide Generation

Nanoscale ◽  
2021 ◽  
Author(s):  
Rachael Knoblauch ◽  
Chris Geddes
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Plasmonic Enhancement ◽  
Cancer Treatments

While the utility of reactive oxygen species in photodynamic therapies for both cancer treatments and antimicrobial applications has received much attention, the inherent potential of reactive nitrogen species (RNS) including...

Mechanical traumatic injury without circulatory shock causes cardiomyocyte apoptosis: role of reactive nitrogen and reactive oxygen species

2005 ◽  
Vol 288 (6) ◽  
pp. H2811-H2818 ◽  
Author(s):  
Ling Tao ◽  
Hui-Rong Liu ◽  
Feng Gao ◽  
Yan Qu ◽  
Theodore A. Christopher ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Cell Death ◽  
Cardiac Dysfunction ◽  
Traumatic Injury ◽  
Reactive Oxygen ◽  
Cardiomyocyte Apoptosis ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species

Apoptotic cell death plays a critical role in tissue injury and organ dysfunction under a variety of pathological conditions. The present study was designed to determine whether apoptosis may contribute to posttraumatic cardiac dysfunction, and if so, to investigate the mechanisms involved. Male adult mice were subjected to nonlethal traumatic injury, and cardiomyocyte apoptosis, cardiac function, and cardiac production of reactive oxygen/nitrogen species were determined. Modified Noble-Collip drum trauma did not result in circulatory shock, and the 24-h survival rate was 100%. No direct mechanical traumatic injury was observed in the heart immediately after trauma. However, cardiomyocyte apoptosis gradually increased and reached a maximal level 12 h after trauma. Significantly, cardiac dysfunction was observed 24 h after trauma in the isolated perfused heart. This was completely reversed when apoptosis was blocked by administration of a nonselective caspase inhibitor immediately after trauma. In the traumatized hearts, reactive nitrogen species (e.g., nitric oxide) and reactive oxygen species (e.g., superoxide) were both significantly increased, and maximal nitric oxide production preceded maximal apoptosis. Moreover, a highly cytotoxic reactive species, peroxynitrite, was markedly increased in the traumatic heart, and there was a significant positive correlation between cardiac nitrotyrosine content and caspase 3 activity. Our present study demonstrated for the first time that nonlethal traumatic injury caused delayed cell death and that apoptotic cardiomyocyte death contributes to posttrauma organ dysfunction. Antiapoptotic treatments, such as blockade of reactive nitrogen oxygen species generation, may be novel strategies in reducing posttrauma multiple organ failure.

scholarly journals Unraveling the Photodynamic Activity of Cationic Benzoporphyrin-Based Photosensitizers against Bladder Cancer Cells

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5312
Author(s):  
Ana T. P. C. Gomes ◽  
M. Graça P. M. S. Neves ◽  
Rosa Fernandes ◽  
Carlos F. Ribeiro ◽  
José A. S. Cavaleiro ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Bladder Cancer ◽  
Singlet Oxygen ◽  
Cancer Cells ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
Oxygen Formation ◽  
Bladder Cancer Cells ◽  
Photodynamic Activity ◽  
Singlet Oxygen Formation

In this study, we report the preparation of new mono-charged benzoporphyrin complexes by reaction of the appropriate neutral benzoporphyrin with (2,2′-bipyridine)dichloroplatinum(II) and of the analogs’ derivatives synthesized through alkylation of the neutral scaffold with iodomethane. All derivatives were incorporated into polyvinylpyrrolidone (PVP) micelles. The ability of the resultant formulations to generate reactive oxygen species was evaluated, mainly the singlet oxygen formation. Then, the capability of the PVP formulations to act as photosensitizers against bladder cancer cells was assessed. Some of the studied formulations were the most active photosensitizers causing a decrease in HT-1376 cells’ viability. This creates an avenue to further studies related to bladder cancer cells.

Interactions between nitric oxide, oxygen, reactive oxygen species and reactive nitrogen species

2006 ◽  
Vol 34 (5) ◽  
pp. 953-956 ◽  
Author(s):  
G.C. Brown ◽  
V. Borutaite
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Degenerative Diseases ◽  
Nitrogen Species ◽  
Biological Actions ◽  
Ros Reactive Oxygen Species

ROS (reactive oxygen species) and RNS (reactive nitrogen species) are central to the innate immunity that protects us from infection, but also contribute to degenerative diseases and possibly aging. However, ROS and RNS are increasingly recognized to contribute to physiological signalling. This review briefly describes the main interactions between ROS and RNS and shows how their origins, chemistry, metabolism and biological actions are intimately linked.

The Role of Reactive Oxygen Species, Kinases, Hydrogen Sulfide, and Nitric Oxide in the Regulation of Autophagy and Their Impact on Ischemia and Reperfusion Injury in the Heart

2020 ◽  
Vol 16 ◽  
Author(s):  
Andrey Krylatov ◽  
Leonid Maslov ◽  
Sergey Y. Tsibulnikov ◽  
Nikita Voronkov ◽  
Alla Boshchenko ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Hydrogen Sulfide ◽  
Ischemia Reperfusion ◽  
Reactive Oxygen ◽  
Ischemia And Reperfusion ◽  
Oxygen Species ◽  
Ischemia And Reperfusion Injury ◽  
Adaptive Process

: There is considerable evidence in the heart that autophagy in cardiomyocytes is activated by hypoxia/reoxygenation (H/R) or in hearts by ischemia/reperfusion (I/R). Depending upon the experimental model and duration of ischemia, increases in autophagy in this setting maybe beneficial (cardioprotective) or deleterious (exacerbate I/R injury). Aside from the conundrum as to whether or not autophagy is an adaptive process, it is clearly regulated by a number of diverse molecules including reactive oxygen species (ROS), various kinases, hydrogen sulfide (H2S) and nitric oxide (NO). The purpose this review is to address briefly the controversy regarding the role of autophagy in this setting and to examine a variety of disparate molecules that are involved in its regulation.

scholarly journals A Generator of Peroxynitrite Activatable with Red Light

2021 ◽  
Author(s):  
Cristina Parisi ◽  
Mariacristina Failla ◽  
Aurore Fraix ◽  
Luca Menilli ◽  
Francesca Moret ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Nitrogen Species ◽  
Red Light ◽  
Reactive Oxygen ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
New Horizons ◽  
Light Stimuli ◽  
Spatiotemporal Control

The generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) as “unconventional” therapeutics with precise spatiotemporal control by using light stimuli may open entirely new horizons for innovative...

scholarly journals What Did We Accomplish in Fighting Radical Species in Human Health?

Antioxidants ◽  
2021 ◽  
Vol 10 (3) ◽  
pp. 466
Author(s):  
Rachid Skouta
Keyword(s):  
Reactive Oxygen Species ◽  
Human Health ◽  
Reactive Nitrogen Species ◽  
Reactive Oxygen ◽  
The Body ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Nitrogen Species ◽  
Radical Species ◽  
Physiological Level

Maintaining the physiological level of reactive oxygen species (ROS) and reactive nitrogen species (RNS) in the body is highly important in the fight against radical species in the context of human health [...]

Sign in / Sign up

Export Citation Format

Share Document