Interaction of a potential chloride channel blocker with a model transport protein: a spectroscopic and molecular docking investigation

2014 ◽  
Vol 16 (18) ◽  
pp. 8465 ◽  
Author(s):  
Aniruddha Ganguly ◽  
Bijan Kumar Paul ◽  
Soumen Ghosh ◽  
Sasanka Dalapati ◽  
Nikhil Guchhait
Keyword(s):  
Molecular Docking ◽  
Chloride Channel ◽  
Channel Blocker ◽  
Protein A ◽  
Transport Protein ◽  
Chloride Channel Blocker

Interaction of triblock co-polymer micelles with phospholipid-bilayer: a spectroscopic investigation using a potential chloride channel blocker

2015 ◽  
Vol 17 (9) ◽  
pp. 6597-6605 ◽  
Author(s):  
Aniruddha Ganguly ◽  
Soumen Ghosh ◽  
Nikhil Guchhait
Keyword(s):  
Chloride Channel ◽  
Spectroscopic Investigation ◽  
Channel Blocker ◽  
Lipid Vesicles ◽  
Experimental Results ◽  
Phospholipid Bilayer ◽  
Polymer Micelles ◽  
Binding Interaction ◽  
Chloride Channel Blocker ◽  
Egg Pc

Experimental results reveal that addition of P123 to the drug-bound egg-PC vesicles results in a preferential complexation of the drug with the Pluronic leaving the lipid vesicles aside which indicates a substantially stronger binding interaction of the drug with P123 than that with egg-PC.

scholarly journals Chloride channel blocker IAA-94 increases myocardial infarction by reducing calcium retention capacity of the cardiac mitochondria

Life Sciences ◽  
2019 ◽  
Vol 235 ◽  
pp. 116841 ◽  
Author(s):  
Devasena Ponnalagu ◽  
Ahmed Tafsirul Hussain ◽  
Rushi Thanawala ◽  
Jahnavi Meka ◽  
Piotr Bednarczyk ◽  
...  
Keyword(s):  
Myocardial Infarction ◽  
Chloride Channel ◽  
Channel Blocker ◽  
Cardiac Mitochondria ◽  
Retention Capacity ◽  
Calcium Retention ◽  
Chloride Channel Blocker ◽  
Calcium Retention Capacity

scholarly journals Effect of AHC-93, a chloride channel blocker, on the isolated guinea-pig myocardium

2000 ◽  
Vol 82 ◽  
pp. 195
Author(s):  
Tomoaki Saito ◽  
Yoshio Tanaka ◽  
Hikaru Tanaka ◽  
Koki Shigenobu
Keyword(s):  
Guinea Pig ◽  
Chloride Channel ◽  
Channel Blocker ◽  
Chloride Channel Blocker

Improved Islet Yield and Function by Use of a Chloride Channel Blocker During Collagenase Digestion

2011 ◽  
Vol 92 (8) ◽  
pp. 871-877 ◽  
Author(s):  
Takayuki Anazawa ◽  
Yoshihiro Sato ◽  
Takuro Saito ◽  
Takao Tsuchiya ◽  
Akira Kenjo ◽  
...  
Keyword(s):  
Chloride Channel ◽  
Channel Blocker ◽  
Collagenase Digestion ◽  
Chloride Channel Blocker ◽  
And Function

Can a chloride channel blocker mitigate muscle fatigue?

2021 ◽  
Vol 599 (8) ◽  
pp. 2145-2147
Author(s):  
Avery Hinks ◽  
Keenan B. MacDougall ◽  
Parastoo Mashouri ◽  
Ian C. Smith
Keyword(s):  
Muscle Fatigue ◽  
Chloride Channel ◽  
Channel Blocker ◽  
Chloride Channel Blocker

scholarly journals The Effects of the KCNQ Openers Retigabine and Flupirtine on Myotonia in Mammalian Skeletal Muscle Induced by a Chloride Channel Blocker

2012 ◽  
Vol 2012 ◽  
pp. 1-9 ◽  
Author(s):  
Tzu-Rong Su ◽  
Wen-Shan Zei ◽  
Ching-Chyuan Su ◽  
George Hsiao ◽  
Min-Jon Lin
Keyword(s):  
Skeletal Muscle ◽  
Chloride Channel ◽  
Channel Blocker ◽  
Potassium Conductance ◽  
Anticonvulsant Drug ◽  
Mammalian Skeletal Muscle ◽  
Muscle Twitch ◽  
Chloride Channel Blocker ◽  
Potential Alternative ◽  
Murine Skeletal Muscle

The purpose of this study was to investigate the effect of KCNQ (potassium channel, voltage-gated, KQT-like subfamily) openers in preventing myotonia caused by anthracene-9-carboxylic acid (9-AC, a chloride channel blocker). An animal model of myotonia can be elicited in murine skeletal muscle by 9-AC treatment. KCNQ openers, such as retigabine and flupirtine, can inhibit the increased twitch amplitude (0.1 Hz stimulation) and reduce the tetanic fade (20 Hz stimulations) observed in the presence of 9-AC. Furthermore, the prolonged twitch duration of skeletal muscle was also inhibited by retigabine or flupirtine. Lamotrigine (an anticonvulsant drug) has a lesser effect on the muscle twitch amplitude, tetanic fade, and prolonged twitch duration as compared with KCNQ openers. In experiments using intracellular recordings, retigabine and flupirtine clearly reduced the firing frequencies of repetitive action potentials induced by 9-AC. These data suggested that KCNQ openers prevent the myotonia induced by 9-AC, at least partly through enhancing potassium conductance in skeletal muscle. Taken together, these results indicate that KCNQ openers are potential alternative therapeutic agents for the treatment of myotonia.

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