The development of surface-enhanced Raman scattering as a detection modality for portable in vitro diagnostics: progress and challenges

2013 ◽  
Vol 15 (47) ◽  
pp. 20415 ◽  
Author(s):  
Ashley J. Driscoll ◽  
Mark H. Harpster ◽  
Patrick A. Johnson
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
In Vitro Diagnostics ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Multiplexed Liquid Biopsy and Tumor Imaging Using Surface-Enhanced Raman Scattering

Biosensors ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 449
Author(s):  
Francesco Dell’Olio
Keyword(s):  
Raman Scattering ◽  
Single Molecule ◽  
Liquid Biopsy ◽  
Tumor Imaging ◽  
Surface Enhanced Raman Scattering ◽  
Detection Sensitivity ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

The recent improvements in diagnosis enabled by advances in liquid biopsy and oncological imaging significantly better cancer care. Both these complementary approaches, which are used for early tumor detection, characterization, and monitoring, can benefit from applying techniques based on surface-enhanced Raman scattering (SERS). With a detection sensitivity at the single-molecule level, SERS spectroscopy is widely used in cell and molecular biology, and its capability for the in vitro detection of several types of cancer biomarkers is well established. In the last few years, several intriguing SERS applications have emerged, including in vivo imaging for tumor targeting and the monitoring of drug release. In this paper, selected recent developments and trends in SERS applications in the field of liquid biopsy and tumor imaging are critically reviewed, with a special emphasis on results that demonstrate the clinical utility of SERS.

Surface enhanced Raman scattering based reaction monitoring of in vitro decyclization of creatinine → creatine

RSC Advances ◽  
2016 ◽  
Vol 6 (64) ◽  
pp. 58943-58949 ◽  
Author(s):  
Debraj Gangopadhyay ◽  
Poornima Sharma ◽  
Sachin Kumar Singh ◽  
Pushkar Singh ◽  
Volker Deckert ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Surface Enhanced Raman Scattering ◽  
Reaction Monitoring ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

Raman signatures of decyclization of creatinine to creatine appear after 120 min at pH 8, 60 min at pH 10 and 30 min at pH 12. Signature of reversibility at later stages of the reaction.

In vitro concentration dependent detection of creatinine: a surface enhanced Raman scattering and fluorescence study

RSC Advances ◽  
2016 ◽  
Vol 6 (113) ◽  
pp. 112562-112567 ◽  
Author(s):  
Debraj Gangopadhyay ◽  
Poornima Sharma ◽  
Rajib Nandi ◽  
Moumita Das ◽  
Surajit Ghosh ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Fluorescence Spectra ◽  
Surface Enhanced Raman Scattering ◽  
Fluorescence Study ◽  
Consistent Variation ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

(a) SERS spectra and (b) fluorescence spectra of Jaffe complex showing consistent variation relatable to the concentration of CRN.

In vitro monitoring of ring opening of leflunomide: A surface enhanced Raman scattering and DFT based approach

2014 ◽  
Vol 613 ◽  
pp. 127-132 ◽  
Author(s):  
Poornima Sharma ◽  
Debraj Gangopadhyay ◽  
Pushkar Singh ◽  
P.C. Mishra ◽  
Volker Deckert ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Ring Opening ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Common Aspects Influencing the Translocation of SERS to Biomedicine

2018 ◽  
Vol 25 (35) ◽  
pp. 4638-4652 ◽  
Author(s):  
Dionysia Tsoutsi ◽  
Marcos Sanles-Sobrido ◽  
Andreu Cabot ◽  
Pilar-Rivera Gil
Keyword(s):  
Raman Scattering ◽  
State Of The Art ◽  
Surface Enhanced Raman Scattering ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Diagnostic Technologies ◽  
The Impact

This review overviews the impact in biomedicine of surface enhanced. Raman scattering motivated by the great potential we believe this technique has. We present the advantages and limitations of this technique relevant to bioanalysis in vitro and in vivo and how this technique goes beyond the state of the art of traditional analytical, labelling and healthcare diagnostic technologies.

scholarly journals Rapid Detection of Glucose on Nanostructured Gold Film Biosensor by Surface-Enhanced Raman Spectroscopy

Biosensors ◽  
2021 ◽  
Vol 11 (2) ◽  
pp. 54
Author(s):  
Cheng-Ju Sung ◽  
Szu-Han Chao ◽  
Shih-Chieh Hsu
Keyword(s):  
Raman Scattering ◽  
Rhodamine 6G ◽  
Surface Enhanced Raman Scattering ◽  
World Health ◽  
Quantitative Detection ◽  
Glucose Detection ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

In this report, we summarized our development of biosensors for Rhodamine 6G and in vitro glucose detection based on surface-enhanced Raman scattering technology. For the detection of both Rhodamine 6G and in vitro glucose, a nature-patterned substrate with gold films over nanostructures (NPS-AuFON) was used as the surface-enhanced Raman scattering sensor platform. The enhancement factor was calculated at 9 × 107. In the processing of the substrate, cyclic voltammetry was used to form nano-gold particles under different conditions. The Rhodamine 6G and glucose detection were then achieved on this substrate. Furthermore, we combined the potentiostatic technique and electrochemical adsorption to best detect glucose in low concentrations. The glucose oxidation potential (100 mV) was used to capture glucose close to the surface of the NPS-AuFON. The quantitative detection of glucose in solution and in situ inspection were confirmed. Further, we determined that this surface modification technology can reach the goal of experiments set by the World Health Organization to judge whether or not a patient is a diabetic by detecting a glucose concentration of 11.1 mmol/L (mg/dL) at a minimum.

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