Layer-by-layer self-assembly and disassembly of single charged inorganic small molecules: towards surface patterning

2013 ◽  
Vol 15 (36) ◽  
pp. 15172 ◽  
Author(s):  
Mengjiao Cheng ◽  
Chao Jiang ◽  
Zhiyi Ding ◽  
Yajun Zhang ◽  
Yu Fu ◽  
...  
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Surface Patterning ◽  
Layer By Layer

Investigating Zigzag Film Growth Behaviors in Layer-by-Layer Self-Assembly of Small Molecules through a High-Gravity Technique

2015 ◽  
Vol 7 (33) ◽  
pp. 18824-18831 ◽  
Author(s):  
Mengjiao Cheng ◽  
Chao Jiang ◽  
Caijun Luo ◽  
Yajun Zhang ◽  
Feng Shi
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Film Growth ◽  
High Gravity ◽  
Layer By Layer

Abrikosov-like lattices in organic crystals on graphite surface

2014 ◽  
Vol 1663 ◽  
Author(s):  
Alexandre F. Fonseca ◽  
Paulo N. Lisboa-Filho
Keyword(s):  
Small Molecules ◽  
Aromatic Hydrocarbons ◽  
Self Assembly ◽  
Surface Patterning ◽  
Organic Crystals ◽  
Spontaneous Formation ◽  
Vast Literature ◽  
Different Types ◽  
Polycyclic Aromatic ◽  
Initial Results

ABSTRACTThe interest for surface patterning presents a fast increasing in the last few years due to several factors ranging from miniaturization trends and sensor design to worries about the absorption of carcinogenic molecules on inhalable particles. Although the existence of a vast literature regarding the self-assembly and patterning of nanoparticles on different types of surfaces, it remains unclear the dynamics and main mechanisms behind the formation and maintenance of two-dimensional symmetric patterns of small molecules on top of surfaces. In this contribution, we report initial results on an investigation on the similarities between the well-known Abrikosov hexagonal lattices in superconductors, and the spontaneous formation of hexagonal patterns of some small polycyclic aromatic hydrocarbons (PAHs) on top of a graphitic surface. In order to attest our results, some experimental results from literature are compared to the obtained results.

Enzyme-Instructed Self-assembly in Biological Milieu for Theranostics Purpose

2019 ◽  
Vol 26 (8) ◽  
pp. 1351-1365 ◽  
Author(s):  
Zhentao Huang ◽  
Qingxin Yao ◽  
Simin Wei ◽  
Jiali Chen ◽  
Yuan Gao
Keyword(s):  
Small Molecules ◽  
Precision Medicine ◽  
Self Assembly ◽  
Public Healthcare ◽  
Enzymatic Conversion ◽  
Vaccine Adjuvants ◽  
New Paradigm ◽  
Cancer Treatments ◽  
The Past ◽  
Biological Milieu

Precision medicine is in an urgent need for public healthcare. Among the past several decades, the flourishing development in nanotechnology significantly advances the realization of precision nanomedicine. Comparing to well-documented nanoparticlebased strategy, in this review, we focus on the strategy using enzyme instructed selfassembly (EISA) in biological milieu for theranostics purpose. In principle, the design of small molecules for EISA requires two aspects: (1) the substrate of enzyme of interest; and (2) self-assembly potency after enzymatic conversion. This strategy has shown its irreplaceable advantages in nanomedicne, specifically for cancer treatments and Vaccine Adjuvants. Interestingly, all the reported examples rely on only one kind of enzymehydrolase. Therefore, we envision that the application of EISA strategy just begins and will lead to a new paradigm in nanomedicine.

Computational and Experimental Binding Mechanism of DNA-drug Interactions

2019 ◽  
Vol 24 (32) ◽  
pp. 3739-3757 ◽  
Author(s):  
Chandrabose Selvaraj ◽  
Sanjeev K. Singh
Keyword(s):  
Small Molecules ◽  
Self Assembly ◽  
Genetic Material ◽  
Dna Interaction ◽  
Significant Feature ◽  
Drug Molecules ◽  
Potential Applications ◽  
Novel Drug ◽  
Groove Binders ◽  
Molecular Docking And Dynamics

Nucleic acid is the key unit and a predominant genetic material for interpreting the fundamental basis of genetic information in an organism and now it is used for the evolution of a novel group of therapeutics. To identify the potential impact on the biological science, it receives high recognition in therapeutic applications. Due to its selective recognition of molecular targets and pathways, DNA significantly imparts tremendous specificity of action. Examining the properties of DNA holds numerous advantages in assembly, interconnects, computational elements, along with potential applications of DNA self-assembly and scaffolding include nanoelectronics, biosensors, and programmable/autonomous molecular machines. The interaction of low molecular weight, small molecules with DNA is a significant feature in pharmacology. Based on the mode of binding mechanisms, small molecules are categorized as intercalators and groove binders having a significant role in target-based drug development. The understanding mechanism of drug-DNA interaction plays an important role in the development of novel drug molecules with more effective and lesser side effects. This article attempts to outline those interactions of drug-DNA with both experimental and computational advances, including ultraviolet (UV) -visible spectroscopy, fluorescent spectroscopy, circular dichroism, nuclear magnetic resonance (NMR), molecular docking and dynamics, and quantum mechanical applications.

scholarly journals Construction of Chitosan/Alginate Nano-Drug Delivery System for Improving Dextran Sodium Sulfate-Induced Colitis in Mice

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1884
Author(s):  
Mengfei Jin ◽  
Shangyong Li ◽  
Yanhong Wu ◽  
Dandan Li ◽  
Yantao Han
Keyword(s):  
Self Assembly ◽  
Average Diameter ◽  
Mucosal Healing ◽  
Plga Nanoparticles ◽  
Narrow Particle Size Distribution ◽  
Layer By Layer ◽  
Systemic Side Effects ◽  
Assembly Technology ◽  
The Fourier Transform ◽  
Polyelectrolyte Film

(1) Background: In the treatment of ulcerative colitis (UC), accurate delivery and release of anti-inflammatory drugs to the site of inflammation can reduce systemic side effects. (2) Methods: We took advantage of this goal to prepare resveratrol-loaded PLGA nanoparticles (RES-PCAC-NPs) by emulsification solvent volatilization. After layer-by-layer self-assembly technology, we deposited chitosan and alginate to form a three-layer polyelectrolyte film. (3) Results: It can transport nanoparticles through the gastric environment to target inflammation sites and slowly release drugs at a specific pH. The resulting RES-PCAC-NPs have an ideal average diameter (~255 nm), a narrow particle size distribution and a positively charged surface charge (~13.5 mV). The Fourier transform infrared spectroscopy showed that resveratrol was successfully encapsulated into PCAC nanoparticles, and the encapsulation efficiency reached 87.26%. In addition, fluorescence imaging showed that RES-PCAC-NPs with positive charges on the surface can effectively target and accumulate in the inflammation site while continuing to penetrate downward to promote mucosal healing. Importantly, oral RES-PCAC-NPs treatment in DSS-induced mice was superior to other results in significantly improved inflammatory markers of UC. (4) Conclusions: Our results strongly prove that RES-PCAC-NPs can target the inflamed colon for maximum efficacy, and this oral pharmaceutical formulation can represent a promising formulation in the treatment of UC.

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