Molecularly imprinted photonic crystals for the direct label-free distinguishing of l-proline and d-proline

2013 ◽  
Vol 15 (40) ◽  
pp. 17250 ◽  
Author(s):  
Yongli Zhang ◽  
Zeng Pan ◽  
Yanxia Yuan ◽  
Zhiming Sun ◽  
Junkui Ma ◽  
...  
Keyword(s):  
Photonic Crystals ◽  
Label Free ◽  
Molecularly Imprinted ◽  
Direct Label

Photonic crystals: A platform for label-free and enhanced fluorescence biomolecular and cellular assays

2008 ◽  
Vol 1133 ◽  
Author(s):  
Brian T. Cunningham ◽  
Leo Chan ◽  
Patrick C. Mathias ◽  
Nikhil Ganesh ◽  
Sherine George ◽  
...  
Keyword(s):  
Photonic Crystal ◽  
Photonic Crystals ◽  
High Throughput Screening ◽  
High Sensitivity ◽  
Excitation Wavelength ◽  
Label Free ◽  
Crystal Surfaces ◽  
Enhanced Fluorescence ◽  
Preferred Direction ◽  
Label Free Detection

Abstract Photonic crystal surfaces represent a class of resonant optical structures that are capable of supporting high intensity electromagnetic standing waves with near-field and far-field properties that can be exploited for high sensitivity detection of biomolecules and cells. While modulation of the resonant wavelength of a photonic crystal by the dielectric permittivity of adsorbed biomaterials enables label-free detection, the resonance can also be tuned to coincide with the excitation wavelength of common fluorescent tags - including organic molecules and semiconductor quantum dots. Photonic crystals are also capable of efficiently channeling fluorescent emission into a preferred direction for enhanced extraction efficiency. Photonic crystals can be designed to support multiple resonant modes that can perform label free detection, enhanced fluorescence excitation, and enhanced fluorescence extraction simultaneously on the same device. Because photonic crystal surfaces may be inexpensively produced over large surface areas by nanoreplica molding processes, they can be incorporated into disposable labware for applications such as pharmaceutical high throughput screening. In this talk, the optical properties of surface photonic crystals will be reviewed and several applications will be described, including results from screening a 200,000-member chemical compound library for inhibitors of protein-DNA interactions, gene expression microarrays, and high sensitivity of protein biomarkers.

Molecularly imprinted label-free sensor platform for impedimetric detection of 3-monochloropropane-1,2˗diol

2021 ◽  
Vol 328 ◽  
pp. 128986
Author(s):  
Yesim Tugce Yaman ◽  
Gulcin Bolat ◽  
Turkan Busra Saygin ◽  
Serdar Abaci
Keyword(s):  
Label Free ◽  
Molecularly Imprinted ◽  
Sensor Platform

Label-Free Prehybridization DNA Microarray Imaging Using Photonic Crystals for Quantitative Spot Quality Analysis

2010 ◽  
Vol 82 (20) ◽  
pp. 8551-8557 ◽  
Author(s):  
S. George ◽  
I. D. Block ◽  
S. I. Jones ◽  
P. C. Mathias ◽  
V. Chaudhery ◽  
...  
Keyword(s):  
Photonic Crystals ◽  
Dna Microarray ◽  
Quality Analysis ◽  
Label Free ◽  
Spot Quality

scholarly journals Label-Free Monitoring of Human IgG/Anti-IgG Recognition Using Bloch Surface Waves on 1D Photonic Crystals

Biosensors ◽  
2018 ◽  
Vol 8 (3) ◽  
pp. 71 ◽  
Author(s):  
Alberto Sinibaldi ◽  
Agostino Occhicone ◽  
Peter Munzert ◽  
Norbert Danz ◽  
Frank Sonntag ◽  
...  
Keyword(s):  
Photonic Crystals ◽  
Surface Waves ◽  
Dissociation Constants ◽  
Limit Of Detection ◽  
Detection System ◽  
Label Free ◽  
Human Igg ◽  
Surface Mass ◽  
On Chip ◽  
Antibody Interactions

Optical biosensors based on one-dimensional photonic crystals sustaining Bloch surface waves are proposed to study antibody interactions and perform affinity studies. The presented approach utilizes two types of different antibodies anchored at the sensitive area of a photonic crystal-based biosensor. Such a strategy allows for creating two or more on-chip regions with different biochemical features as well as studying the binding kinetics of biomolecules in real time. In particular, the proposed detection system shows an estimated limit of detection for the target antibody (anti-human IgG) smaller than 0.19 nM (28 ng/mL), corresponding to a minimum surface mass coverage of 10.3 ng/cm2. Moreover, from the binding curves we successfully derived the equilibrium association and dissociation constants (KA = 7.5 × 107 M−1; KD = 13.26 nM) of the human IgG–anti-human IgG interaction.

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