Temperature-controlled release by changes in the secondary structure of peptides anchored onto mesoporous silica supports

2014 ◽  
Vol 50 (24) ◽  
pp. 3184-3186 ◽  
Author(s):  
Cristina de la Torre ◽  
Alessandro Agostini ◽  
Laura Mondragón ◽  
Mar Orzáez ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Controlled Release ◽  
Secondary Structure ◽  
Mesoporous Silica ◽  
External Surface ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Silica Supports ◽  
Temperature Controlled ◽  
Mcm 41

Changes in the conformation of a peptide anchored onto the external surface of MCM-41 nanoparticles are used to design temperature-controlled delivery systems.

Fatty Acid Carboxylate- and Anionic Surfactant-Controlled Delivery Systems That Use Mesoporous Silica Supports

2010 ◽  
Vol 16 (33) ◽  
pp. 10048-10061 ◽  
Author(s):  
Carmen Coll ◽  
Elena Aznar ◽  
Ramón Martínez-Máñez ◽  
M. Dolores Marcos ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Fatty Acid ◽  
Mesoporous Silica ◽  
Anionic Surfactant ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Silica Supports

Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose

2009 ◽  
Vol 121 (32) ◽  
pp. 5998-6001 ◽  
Author(s):  
Andrea Bernardos ◽  
Elena Aznar ◽  
María Dolores Marcos ◽  
Ramón Martínez-Máñez ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Supports

scholarly journals Applications of mesoporous silica materials in food – a review

2013 ◽  
Vol 31 (No. 2) ◽  
pp. 99-107 ◽  
Author(s):  
A. Bernardos ◽  
L. Kouřimská
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Digestive System ◽  
Functional Foods ◽  
Bioactive Molecules ◽  
Silica Supports ◽  
Silica Materials ◽  
Mesoporous Silica Materials ◽  
Health Field

Mesoporous silica materials have been developed for some applications in the health field. These solids are used for the controlled release of bioactive molecules, as catalysts in the synthesis of essential nutrients, as sensors to detect unhealthy products etc., with many applications in food technologies. By combining mesoporous silica materials with food, we can create healthier products, the products that improve our quality of life. The development of mesoporous materials applied to food could result in protecting bioactive molecules during their passage though the digestive system. For this reason, the controlled release of bioactive molecules is a very interesting topic for the discipline of food technology. The use of mesoporous silica supports as catalysts in the synthesis of nutrients and as sensors for the detection of unhealthy products, essential in food, is in great demand industrially for the manufacture of functional foods and films for food and industrial packaging. This review shows some examples of silica materials and their applications in food.  

scholarly journals MCM-41 mesoporous silica anoparticles and their adsorption for targeting drug delivery systems

2019 ◽  
Vol 2 (4) ◽  
pp. 95-102
Author(s):  
Nguyet Tran Anh Dau ◽  
Hieu Van Le ◽  
Van Thi Thanh Tran
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Drug Delivery Systems ◽  
Structural Characteristics ◽  
Mesoporous Silica Nanoparticles ◽  
Delivery Systems ◽  
Maximum Adsorption Capacity ◽  
Isothermal Adsorption ◽  
Water As Solvent ◽  
Mcm 41

MCM-41 mesoporous silica nanoparticles were successfully synthesized by the condensation of tetraorthosilicate precursor (TEOS) using cetyltrimethylammonium bromide (CTAB) as the orientation substance in alkaline (pH = 9–12), deionized water as solvent. The samples were calcinated at 550°C for 5 hours. The structural characteristics of samples were analyzed by using Small angle X-ray diffraction, transmission electron microscopy (TEM), FT-IR and isothermal adsorption of nitrogen. Optimizing the fabrication parameters, MCM-41 particles have been obtained with a spherical shape, size of 80-140 nm, pore diameter of 2–5 nm and surface area (BET) of 986,683 m2g-1. Rhodamine B adsorption of MCM-41 showed that the maximum adsorption capacity value was 299,696 mg/g, suggesting the potential of this material to design of controlled drug delivery systems.

Controlled Drug Delivery Systems

Drug Delivery ◽  
2001 ◽  
Author(s):  
W. Mark Saltzman
Keyword(s):  
Drug Delivery ◽  
Controlled Release ◽  
Sustained Release ◽  
Drug Delivery Systems ◽  
Active Agent ◽  
Polymeric Materials ◽  
Spatial Localization ◽  
Delivery Systems ◽  
Controlled Delivery ◽  
Drug Modification

In most forms of drug delivery, spatial localization and duration of drug concentration are constrained by organ physiology and metabolism. For example, drugs administered orally will distribute to tissues based on the principles of diffusion, permeation, and flow presented in Part II of this book. If the duration of therapy provided by a single administration is insufficient, the drug must be readministered. Localization of drug can be controlled by injection, but only within limited spatial constraints, and effectiveness after an injection is usually short-lived. Controlled-delivery systems offer an alternative approach to regulating both the duration and spatial localization of therapeutic agents. In controlled delivery, the active agent is combined with other (usually synthetic) components to produce a delivery system. Unlike drug modification, which results in new agents that are single molecules, or assemblies of a limited number of molecules, drug delivery systems are usually macroscopic. Like drug modification, controlled-delivery systems frequently involve combinations of active agents with inert polymeric materials. In this text, controlled-delivery systems are distinguished from “sustained-release” drug formulations. Sustained release is often achieved by mixing an active agent with excipients or binders that alter the agent’s rate of dissolution in the intestinal tract or adsorption from a local injection site. The distinction between sustained release (often achieved by drug formulation) and controlled delivery or controlled release is somewhat arbitrary. In our definition, controlled delivery systems must (1) include a component that can be engineered to regulate an essential characteristic (e.g., duration of release, rate of release, or targeting) and (2) have a duration of action longer than a day. Many polymeric materials are available for the development of drug delivery systems (see Appendix A). Non-degradable, hydrophobic polymers have been used the most extensively. Reservoir drug delivery devices, in which a liquid reservoir of drug is enclosed in a silicone elastomer tube, were first demonstrated to provide controlled release of small molecules several decades ago [1]. This discovery eventually led to clinically useful devices, including the Norplant® (Wyeth-Ayerst Laboratories) contraceptive delivery system, which provides reliable delivery of levonorgestrel for 5 years following subcutaneous implantation.

Enzyme-Mediated Controlled Release Systems by Anchoring Peptide Sequences on Mesoporous Silica Supports

2011 ◽  
Vol 50 (9) ◽  
pp. 2138-2140 ◽  
Author(s):  
Carmen Coll ◽  
Laura Mondragón ◽  
Ramón Martínez-Máñez ◽  
Félix Sancenón ◽  
M. Dolores Marcos ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Supports

Enzyme-Responsive Controlled Release Using Mesoporous Silica Supports Capped with Lactose

2009 ◽  
Vol 48 (32) ◽  
pp. 5884-5887 ◽  
Author(s):  
Andrea Bernardos ◽  
Elena Aznar ◽  
María Dolores Marcos ◽  
Ramón Martínez-Máñez ◽  
Félix Sancenón ◽  
...  
Keyword(s):  
Controlled Release ◽  
Mesoporous Silica ◽  
Silica Supports
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