scholarly journals Early amyloid β-protein aggregation precedes conformational change

2014 ◽  
Vol 50 (40) ◽  
pp. 5373-5375 ◽  
Author(s):  
Bogdan Barz ◽  
Olujide O. Olubiyi ◽  
Birgit Strodel
Keyword(s):  
Molecular Dynamics ◽  
Protein Aggregation ◽  
Molecular Dynamics Simulations ◽  
Conformational Change ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Β Protein ◽  
Dynamics Simulations

The aggregation of amyloid-β protein (1–42) is studied at experimental concentrations using all-atom molecular dynamics simulations.

Destabilization of Alzheimer’s Aβ42 protofibrils with acyclovir, carmustine, curcumin, and tetracycline: Insights from molecular dynamics simulations

2021 ◽  
Author(s):  
Ishrat Jahan ◽  
Shahid M Nayeem
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Molecular Dynamics ◽  
Neurodegenerative Diseases ◽  
Molecular Dynamics Simulations ◽  
Amyloid Β ◽  
Neural Tissue ◽  
Amyloid Β Peptide ◽  
Characteristic Symptom ◽  
Dynamics Simulations

One of the most common dementia among neurodegenerative diseases is Alzheimer’s disease (AD). The characteristic symptom of AD is the deposition and aggregation of amyloid-β-peptide in the neural tissue. A...

Conjugation of RTHLVFFARK to human lysozyme creates a potent multifunctional modulator for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity

2020 ◽  
Vol 8 (11) ◽  
pp. 2256-2268 ◽  
Author(s):  
Xi Li ◽  
Wenjuan Wang ◽  
Xiaoyan Dong ◽  
Yan Sun
Keyword(s):  
Protein Aggregation ◽  
Amyloid Β ◽  
Amyloid Β Protein ◽  
Human Lysozyme ◽  
Β Protein

Conjugation of alkaline decapeptide (RTHLVFFARK) to lysozyme creates a potent multifunctional modulator (R-hLys) for Cu2+-mediated amyloid β-protein aggregation and cytotoxicity.

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