A highly sensitive chemiluminescent metalloimmunoassay for H1N1 influenza virus detection based on a silver nanoparticle label

2013 ◽  
Vol 49 (90) ◽  
pp. 10563 ◽  
Author(s):  
Yanxia Li ◽  
Mei Hong ◽  
Bin Qiu ◽  
Zhenyu Lin ◽  
Zongwei Cai ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Silver Nanoparticle ◽  
Virus Detection ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Highly Sensitive ◽  
Influenza Virus Detection

Silver Nanoparticle Based Codelivery of Oseltamivir to Inhibit the Activity of the H1N1 Influenza Virus through ROS-Mediated Signaling Pathways

2016 ◽  
Vol 8 (37) ◽  
pp. 24385-24393 ◽  
Author(s):  
Yinghua Li ◽  
Zhengfang Lin ◽  
Mingqi Zhao ◽  
Tiantian Xu ◽  
Changbing Wang ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Signaling Pathways ◽  
Silver Nanoparticle ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus

Highly sensitive electrochemical immunoassay for H1N1 influenza virus based on copper-mediated amplification

2012 ◽  
Vol 48 (52) ◽  
pp. 6562 ◽  
Author(s):  
Yanxia Li ◽  
Mei Hong ◽  
Yanqin Lin ◽  
Qiu Bin ◽  
Zhenyu Lin ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Electrochemical Immunoassay ◽  
H1n1 Influenza Virus ◽  
Highly Sensitive

scholarly journals Sequential Seasonal H1N1 Influenza Virus Infections Protect Ferrets against Novel 2009 H1N1 Influenza Virus

2012 ◽  
Vol 87 (3) ◽  
pp. 1400-1410 ◽  
Author(s):  
Donald M. Carter ◽  
Chalise E. Bloom ◽  
Eduardo J. M. Nascimento ◽  
Ernesto T. A. Marques ◽  
Jodi K. Craigo ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Cross Reactivity ◽  
Influenza Viruses ◽  
The Novel ◽  
Virus Infections ◽  
H1n1 Influenza Virus ◽  
Virus Shedding ◽  
2009 H1n1 ◽  
Novel H1n1 Influenza

ABSTRACTIndividuals <60 years of age had the lowest incidence of infection, with ∼25% of these people having preexisting, cross-reactive antibodies to novel 2009 H1N1 influenza. Many people >60 years old also had preexisting antibodies to novel H1N1. These observations are puzzling because the seasonal H1N1 viruses circulating during the last 60 years were not antigenically similar to novel H1N1. We therefore hypothesized that a sequence of exposures to antigenically different seasonal H1N1 viruses can elicit an antibody response that protects against novel 2009 H1N1. Ferrets were preinfected with seasonal H1N1 viruses and assessed for cross-reactive antibodies to novel H1N1. Serum from infected ferrets was assayed for cross-reactivity to both seasonal and novel 2009 H1N1 strains. These results were compared to those of ferrets that were sequentially infected with H1N1 viruses isolated prior to 1957 or more-recently isolated viruses. Following seroconversion, ferrets were challenged with novel H1N1 influenza virus and assessed for viral titers in the nasal wash, morbidity, and mortality. There was no hemagglutination inhibition (HAI) cross-reactivity in ferrets infected with any single seasonal H1N1 influenza viruses, with limited protection to challenge. However, sequential H1N1 influenza infections reduced the incidence of disease and elicited cross-reactive antibodies to novel H1N1 isolates. The amount and duration of virus shedding and the frequency of transmission following novel H1N1 challenge were reduced. Exposure to multiple seasonal H1N1 influenza viruses, and not to any single H1N1 influenza virus, elicits a breadth of antibodies that neutralize novel H1N1 even though the host was never exposed to the novel H1N1 influenza viruses.

scholarly journals Detection of influenza virus in rectal swabs of patients admitted in hospital for febrile illnesses in Thailand

2021 ◽  
Vol 9 ◽  
pp. 205031212198963
Author(s):  
Artit Sangkakam ◽  
Pasin Hemachudha ◽  
Abhinbhen W Saraya ◽  
Benjamard Thaweethee-Sukjai ◽  
Thaniwan Cheun-Arom ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Gastrointestinal Tract ◽  
Hospital Stay ◽  
Rectal Swab ◽  
Average Length ◽  
Gastrointestinal Symptoms ◽  
Virus Detection ◽  
Length Of Hospital Stay ◽  
Nasopharyngeal Swab ◽  
Influenza Virus Detection

Introduction: Influenza virus favours the respiratory tract as its primary site of host entry and replication, and it is transmitted mainly via respiratory secretions. Nasopharyngeal swab is the gold standard specimen type for influenza detection, but several studies have also suggested that the virus replicates in the human gastrointestinal tract. Methods: A retrospective study was conducted on all patients positive for influenza virus and initially recruited as part of the PREDICT project from 2017 to 2018. The objectives of the study were to investigate whether rectal swab could aid in improving influenza detection, and if there was any correlation between gastrointestinal disturbances and severity of infection, using length of hospital stay as an indicator of severity. Results: Of the 51 influenza-positive patients, 12 had detectable influenza virus in their rectal swab. Among these 12 rectal swab positive patients, influenza virus was not detected in the nasopharyngeal swab of three of them. Gastrointestinal symptoms were observed for 28.2% patients with a negative rectal swab negative and 25.0% patients with a positive rectal swab. Average length of hospital stay was 4.2 days for rectal swab positive group and 3.7 days for rectal swab negative group. This difference was not statistically significant (p = 0.288). Conclusions: There is no correlation between influenza virus detection in rectal swab and gastrointestinal disturbances or disease severity, and there is currently insufficient evidence to support replicative ability in the gastrointestinal tract.

scholarly journals Individual Antibody and T Cell Responses to Vaccination and Infection with the 2009 Pandemic Swine-Origin H1N1 Influenza Virus

2011 ◽  
Vol 31 (5) ◽  
pp. 900-912 ◽  
Author(s):  
Gillian M. Air ◽  
JingQi Feng ◽  
Tao Chen ◽  
Michelle L. Joachims ◽  
Judith A. James ◽  
...  
Keyword(s):  
Influenza Virus ◽  
T Cell ◽  
T Cell Responses ◽  
H1n1 Influenza ◽  
H1n1 Influenza Virus ◽  
Cell Responses

Anti-Inflammatory Effect of Thalidomide on H1N1 Influenza Virus-Induced Pulmonary Injury in Mice

Inflammation ◽  
2014 ◽  
Vol 37 (6) ◽  
pp. 2091-2098 ◽  
Author(s):  
Haiyan Zhu ◽  
Xunlong Shi ◽  
Dianwen Ju ◽  
Hai Huang ◽  
Wei Wei ◽  
...  
Keyword(s):  
Influenza Virus ◽  
H1n1 Influenza ◽  
Pulmonary Injury ◽  
H1n1 Influenza Virus ◽  
Anti Inflammatory ◽  
Inflammatory Effect
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