Extending the tissue penetration capability of conventional photosensitisers: a carbon quantum dot–protoporphyrin IX conjugate for use in two-photon excited photodynamic therapy

2013 ◽  
Vol 49 (79) ◽  
pp. 8934 ◽  
Author(s):  
Colin Fowley ◽  
Nikolitsa Nomikou ◽  
Anthony P. McHale ◽  
Bridgeen McCaughan ◽  
John F. Callan
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Protoporphyrin Ix ◽  
Tissue Penetration ◽  
Two Photon ◽  
Carbon Quantum Dot

Carbon quantum dot–NO photoreleaser nanohybrids for two-photon phototherapy of hypoxic tumors

2015 ◽  
Vol 51 (1) ◽  
pp. 81-84 ◽  
Author(s):  
Colin Fowley ◽  
Anthony P. McHale ◽  
Bridgeen McCaughan ◽  
Aurore Fraix ◽  
Salvatore Sortino ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Tumor Volume ◽  
Carbon Quantum Dots ◽  
Pancreatic Tumors ◽  
Two Photon ◽  
Carbon Quantum Dot ◽  
Nir Light ◽  
Photon Excitation ◽  
Reduce Tumor Volume

Carbon quantum dots conjugated with a NO photodonor reduce tumor volume in mice bearing human xenograft BXPc-3 pancreatic tumors upon two-photon excitation with NIR light.

Biocompatible CdSe quantum dot-based photosensitizer under two-photon excitation for photodynamic therapy

2011 ◽  
Vol 21 (8) ◽  
pp. 2455 ◽  
Author(s):  
Zu-De Qi ◽  
Dong-Wei Li ◽  
Peng Jiang ◽  
Feng-Lei Jiang ◽  
Yue-Sheng Li ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Two Photon ◽  
Photon Excitation ◽  
Cdse Quantum Dot ◽  
Two Photon Excitation

scholarly journals Evolution of Nanoparticle-Mediated Photodynamic Therapy: From Superficial to Deep-Seated Cancers

Molecules ◽  
2019 ◽  
Vol 24 (3) ◽  
pp. 520 ◽  
Author(s):  
Maharajan Sivasubramanian ◽  
Yao Chuang ◽  
Leu-Wei Lo
Keyword(s):  
Photodynamic Therapy ◽  
Free Radicals ◽  
Tumor Location ◽  
Tissue Penetration ◽  
Invasive Treatment ◽  
X Ray ◽  
Two Photon ◽  
Overall Efficiency ◽  
Potential Therapeutic Intervention

Enthusiasm for photodynamic therapy (PDT) as a potential therapeutic intervention for cancer has increased exponentially in recent decades. Photodynamic therapy constitutes a clinically approved, minimally invasive treatment modality that uses a photosensitizer (light absorbing molecule) and light to kill cancer cells. The principle of PDT is, when irradiated with a light of a suitable wavelength, a photosensitizer absorbs the light energy and generates cytotoxic free radicals through various mechanisms. The overall efficiency of PDT depends on characteristics of activation light and in-situ dosimetry, including the choice of photosensitizer molecule, wavelength of the light, and tumor location and microenvironment, for instance, the use of two-photon laser or an X-ray irradiator as the light source increases tissue-penetration depth, enabling it to achieve deep PDT. In this mini-review, we discuss the various designs and strategies for single, two-photon, and X-ray-mediated PDT for improved clinical outcomes.

Two-photon photodynamic therapy of C6 cells by means of 5-aminolevulinic acid induced protoporphyrin IX

2007 ◽  
Vol 87 (3) ◽  
pp. 174-182 ◽  
Author(s):  
Tobias J. Beck ◽  
Marius Burkanas ◽  
Saulius Bagdonas ◽  
Zita Krivickiene ◽  
Wolfgang Beyer ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix ◽  
C6 Cells ◽  
Two Photon

A graphene quantum dot-based multifunctional two-photon nanoprobe for the detection and imaging of intracellular glutathione and enhanced photodynamic therapy

The Analyst ◽  
2018 ◽  
Vol 143 (20) ◽  
pp. 4967-4973 ◽  
Author(s):  
Hong-Min Meng ◽  
Di Zhao ◽  
Na Li ◽  
Junbiao Chang
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Graphene Quantum Dot ◽  
Two Photon ◽  
Intracellular Glutathione

A NIR GQD-based multifunctional two-photon nanoprobe was reported for GSH detection and enhanced PDT.

Quantum dot-sensitiser conjugates for two-photon excited photodynamic therapy

2015 ◽  
Vol 12 (3) ◽  
pp. 341
Author(s):  
Colin Fowley ◽  
Anthony P. McHale ◽  
Bridgeen McCaughan ◽  
Aurore Fraix ◽  
Salvatore Sortino ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Quantum Dot ◽  
Two Photon

Protoporphyrin IX Fluorescence Photobleaching and the Response of Rat Barrett's Esophagus Following 5-aminolevulinic Acid Photodynamic Therapy

2006 ◽  
Vol 82 (6) ◽  
pp. 1638 ◽  
Author(s):  
Ingrid A. Boere ◽  
Dominic J. Robinson ◽  
Henriette S. de Bruijn ◽  
Jolanda Kluin ◽  
Hugo W. Tilanus ◽  
...  
Keyword(s):  
Photodynamic Therapy ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Aminolevulinic Acid ◽  
Protoporphyrin Ix
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