Fe-promoted cross coupling of homobenzylic methyl ethers with Grignard reagents via sp3 C–O bond cleavage

2013 ◽  
Vol 49 (71) ◽  
pp. 7794 ◽  
Author(s):  
Shuang Luo ◽  
Da-Gang Yu ◽  
Ru-Yi Zhu ◽  
Xin Wang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

ChemInform Abstract: Fe-Promoted Cross Coupling of Homobenzylic Methyl Ethers with Grignard Reagents via sp3C-O Bond Cleavage.

ChemInform ◽  
2013 ◽  
Vol 44 (52) ◽  
pp. no-no
Author(s):  
Shuang Luo ◽  
Da-Gang Yu ◽  
Ru-Yi Zhu ◽  
Xin Wang ◽  
Lei Wang ◽  
...  
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

ChemInform Abstract: Nickel-Catalyzed Cross-Coupling of Anisoles with Alkyl Grignard Reagents via C-O Bond Cleavage.

ChemInform ◽  
2016 ◽  
Vol 47 (4) ◽  
pp. no-no
Author(s):  
Mamoru Tobisu ◽  
Tsuyoshi Takahira ◽  
Naoto Chatani
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

scholarly journals Nickel-Catalyzed Cross-Coupling of Anisoles with Alkyl Grignard Reagents via C–O Bond Cleavage

2015 ◽  
Vol 17 (17) ◽  
pp. 4352-4355 ◽  
Author(s):  
Mamoru Tobisu ◽  
Tsuyoshi Takahira ◽  
Naoto Chatani
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

Ni-Catalyzed cross-coupling of aryl thioethers with alkyl Grignard reagents via C–S bond cleavage

2018 ◽  
Vol 54 (67) ◽  
pp. 9313-9316 ◽  
Author(s):  
Dan Zhu ◽  
Lei Shi
Keyword(s):  
Bond Cleavage ◽  
Cross Coupling ◽  
Grignard Reagents

A Ni-catalyzed cross-coupling of aryl thioethers with alkyl Grignard reagents, accompanied by the cleavage of the C(aryl)–SMe bond, has been presented.

Fe-Catalyzed Conjunctive Cross-Couplings of Unactivated Alkenes with Grignard Reagents

2020 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Cassandra R. Youshaw ◽  
Mingbin Yuan ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Functional Groups ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Turnover Frequency ◽  
Diverse Range ◽  
Cascade Cyclization ◽  
Radical Cascade

The first iron-catalyzed three-component cross-coupling of unactivated olefins with alkyl halides and Grignard reagents is reported. The reaction operates under fast turnover frequency and tolerates a diverse range of sp2-hybridized nucleophiles, alkyl halides, and unactivated olefins bearing diverse functional groups to yield the desired 1,2-alkylarylated products with high regiocontrol. Further, we demonstrate that this protocol is amenable for the synthesis of new (hetero)carbocycles including tetrahydrofurans and pyrrolidines via a three-component radical cascade cyclization/arylation that forges three new C-C bonds.

Design and Development of Fe-Catalyzed Intra- and Intermolecular Carbofunctionalization of Vinyl Cyclopropanes

2019 ◽  
Author(s):  
Lei Liu ◽  
Wes Lee ◽  
Mingbin Yuan ◽  
Chris Acha ◽  
Michael B. Geherty ◽  
...  
Keyword(s):  
Bond Formation ◽  
Cross Coupling ◽  
Alkyl Halides ◽  
Grignard Reagents ◽  
Mechanistic Studies ◽  
Radical Intermediates ◽  
Design And Implementation ◽  
Solvent Cage ◽  
Radical Cascade ◽  
Radical Processes

Design and implementation of the first (asymmetric) Fe-catalyzed intra- and intermolecular difunctionalization of vinyl cyclopropanes (VCPs) with alkyl halides and aryl Grignard reagents has been realized via a mechanistically driven approach. Mechanistic studies support the diffusion of the alkyl radical intermediates out of the solvent cage to participate in an intra- or -intermolecular radical cascade with the VCP followed by re-entering the Fe radical cross-coupling cycle to undergo selective C(sp2)-C(sp3) bond formation. Overall, we provide new design principles for Fe-mediated radical processes and underscore the potential of using combined computations and experiments to accelerate the development of challenging transformations.

Novel cross-coupling reactions between organotellurides and Grignard reagents employing a MnCl2/CuI catalytic system

2012 ◽  
Vol 53 (28) ◽  
pp. 3556-3559 ◽  
Author(s):  
Marcio S. Silva ◽  
Renan S. Ferrarini ◽  
Bruno A. Sousa ◽  
Fabiano T. Toledo ◽  
João V. Comasseto ◽  
...  
Keyword(s):  
Catalytic System ◽  
Cross Coupling ◽  
Grignard Reagents ◽  
Coupling Reactions ◽  
Cross Coupling Reactions
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