A catalytic multicomponent coupling reaction for the enantioselective synthesis of spiroacetals

2013 ◽  
Vol 49 (26) ◽  
pp. 2715 ◽  
Author(s):  
Lara Cala ◽  
Abraham Mendoza ◽  
Francisco J. Fañanás ◽  
Félix Rodríguez
Keyword(s):  
Coupling Reaction ◽  
Enantioselective Synthesis ◽  
Multicomponent Coupling

ChemInform Abstract: A Catalytic Multicomponent Coupling Reaction for the Enantioselective Synthesis of Spiroacetals.

ChemInform ◽  
2013 ◽  
Vol 44 (28) ◽  
pp. no-no
Author(s):  
Lara Cala ◽  
Abraham Mendoza ◽  
Francisco J. Fananas ◽  
Felix Rodriguez
Keyword(s):  
Coupling Reaction ◽  
Enantioselective Synthesis ◽  
Multicomponent Coupling

Nickel-Catalyzed Multicomponent Coupling Reaction of Alkyl Halides, Isocyanides and H2O: An Expedient Way to Access Alkyl Amides

Synthesis ◽  
2020 ◽  
Vol 52 (22) ◽  
pp. 3466-3472
Author(s):  
Yunkui Liu ◽  
Bingwei Zhou ◽  
Qiao Li ◽  
Hongwei Jin
Keyword(s):  
Functional Group ◽  
Coupling Reaction ◽  
Alkyl Halides ◽  
Previous Literature ◽  
Catalytic Cycle ◽  
Reaction Conditions ◽  
Multicomponent Coupling ◽  
Easy Operation

We herein describe a Ni-catalyzed multicomponent coupling reaction of alkyl halides, isocyanides, and H2O to access alkyl amides. Bench-stable NiCl2(dppp) is competent to initiate this transformation under mild reaction conditions, thus allowing easy operation and adding practical value. Substrate scope studies revealed a broad functional group tolerance and generality of primary and secondary alkyl halides in this protocol. A plausible catalytic cycle via a SET process is proposed based on preliminary experiments and previous literature.

scholarly journals PEG-embedded KBr3: A recyclable catalyst for multicomponent coupling reaction for the efficient synthesis of functionalized piperidines

2011 ◽  
Vol 7 ◽  
pp. 1334-1341 ◽  
Author(s):  
Sanny Verma ◽  
Suman L Jain ◽  
Bir Sain
Keyword(s):  
Coupling Reaction ◽  
Recyclable Catalyst ◽  
Efficient Synthesis ◽  
Molecular Bromine ◽  
Keto Ester ◽  
One Step ◽  
High Yields ◽  
Multicomponent Coupling ◽  
Three Component Coupling

PEG-embedded potassium tribromide ([K+PEG]Br3 −) was found to be an efficient and recyclable catalyst for the synthesis of functionalized piperidines in high yields in a one step, three component coupling between aldehyde, amine and β-keto ester. At the end of the reaction the [K+PEG]Br3 − was readily regenerated from the reaction mixture by treating the residue containing [K+PEG]Br− with molecular bromine.

ChemInform Abstract: Regio- and Stereoselective Multicomponent Coupling Reaction of Alkynes and Dimethylzinc Involving Allylnickelacycles.

ChemInform ◽  
2012 ◽  
Vol 43 (47) ◽  
pp. no-no
Author(s):  
Takamichi Mori ◽  
Toshiyuki Nakamura ◽  
Gen Onodera ◽  
Masanari Kimura
Keyword(s):  
Coupling Reaction ◽  
Multicomponent Coupling

ChemInform Abstract: A Multicomponent Coupling Reaction Induced by Insertion of Arynes into the C=O Bond of Formamide.

ChemInform ◽  
2011 ◽  
Vol 42 (48) ◽  
pp. no-no
Author(s):  
Eito Yoshioka ◽  
Shigeru Kohtani ◽  
Hideto Miyabe
Keyword(s):  
Coupling Reaction ◽  
Multicomponent Coupling

Multicomponent Coupling Reaction of Perfluoroarenes with 1,3-Butadiene and Aryl Grignard Reagents Promoted by an Anionic Ni(II) Complex

2016 ◽  
Vol 18 (19) ◽  
pp. 4868-4871 ◽  
Author(s):  
Takanori Iwasaki ◽  
Asuka Fukuoka ◽  
Xin Min ◽  
Wataru Yokoyama ◽  
Hitoshi Kuniyasu ◽  
...  
Keyword(s):  
Coupling Reaction ◽  
Grignard Reagents ◽  
Multicomponent Coupling

A Concise Enantioselective Synthesis of (S)-Preclamol via Asymmetric Catalytic Negishi Cross-Coupling Reaction

Synlett ◽  
2019 ◽  
Vol 30 (07) ◽  
pp. 860-862 ◽  
Author(s):  
Yun Zhou ◽  
Chunxiao Liu ◽  
Lifeng Wang ◽  
Leng Han ◽  
Shicong Hou ◽  
...  
Keyword(s):  
Total Yield ◽  
Coupling Reaction ◽  
Cross Coupling ◽  
Enantioselective Synthesis ◽  
Synthetic Approach ◽  
Chiral Drugs ◽  
Asymmetric Catalytic ◽  
Cross Coupling Reaction ◽  
Tertiary Carbon ◽  
Key Steps

A novel, concise, and efficient enantioselective synthesis of (S)-preclamol (87% ee, 51% total yield) has been developed. The key steps of this synthetic approach included cobalt-catalyzed asymmetric catalytic cross-coupling of α-bromo ester with arylzinc and the reduction of chiral ester to diol with a tertiary carbon atom. Moreover, it was demonstrated that our enantioselective Negishi cross-coupling was a powerful tool to construct stereogenic benzylmethyl center in chiral drugs on a gram scale.

ChemInform Abstract: Copper-Catalyzed One-Pot Multicomponent Coupling Reaction of Phenols, Amides, and 4-Bromophenyl Iodide.

ChemInform ◽  
2009 ◽  
Vol 40 (10) ◽  
Author(s):  
Wenming Chen ◽  
Jianjun Li ◽  
Dongmei Fang ◽  
Chun Feng ◽  
Chenggang Zhang
Keyword(s):  
Coupling Reaction ◽  
One Pot ◽  
Multicomponent Coupling
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