scholarly journals Characterisation and evaluation of the impact of microfabricated pockets on the performance of limbal epithelial stem cells in biodegradable PLGA membranes for corneal regeneration

2014 ◽  
Vol 2 (5) ◽  
pp. 723-734 ◽  
Author(s):  
Ilida Ortega ◽  
Robert McKean ◽  
Anthony J. Ryan ◽  
Sheila MacNeil ◽  
Frederik Claeyssens
Keyword(s):  
Stem Cells ◽  
Epithelial Stem Cells ◽  
Corneal Regeneration ◽  
Limbal Epithelial Stem Cells ◽  
The Impact

scholarly journals Stem Cells in the Path of Light, from Corneal to Retinal Reconstruction

Biomedicines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 873
Author(s):  
Ovidiu Samoila ◽  
Lacramioara Samoila
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Clinical Success ◽  
Corneal Stroma ◽  
Cell Transplant ◽  
Inclusion Criteria ◽  
Epithelial Stem Cells ◽  
Corneal Epithelial ◽  
Stem Cells Transplantation ◽  
Limbal Epithelial Stem Cells

The future of eye reconstruction invariably includes stem cells transplantation. Corneal limbus, corneal stroma, trabeculum, retinal cells, optic nerve, and all structures that are irreversibly damaged and have no means to be repaired or replaced, through conventional treatment or surgery, represent targets for stem cell reconstruction. This review tries to answer the question if there is any clinical validation for stem therapies, so far, starting from the cornea and, on the path of light, arriving to the retina. The investigation covers the last 10 years of publications. From 2385 published sources, we found 56 clinical studies matching inclusion criteria, 39 involving cornea, and 17 involving retina. So far, corneal epithelial reconstruction seems well validated clinically. Enough clinical data are collected to allow some form of standardization for the stem cell transplant procedures. Cultivated limbal epithelial stem cells (CLET), simple limbal epithelial transplant (SLET), and oral mucosa transplantation are implemented worldwide. In comparison, far less patients are investigated in retinal stem reconstructions, with lower anatomical and clinical success, so far. Intravitreal, subretinal, and suprachoroidal approach for retinal stem therapies face specific challenges.

scholarly journals Pax 6 Controls Neural Crest Potential of Limbal Niche Cells to Support Self-Renewal of Limbal Epithelial Stem Cells

2019 ◽  
Vol 9 (1) ◽  
Author(s):  
Szu-Yu Chen ◽  
Anny M. S. Cheng ◽  
Yuan Zhang ◽  
Ying-Ting Zhu ◽  
Hua He ◽  
...  
Keyword(s):  
Stem Cells ◽  
Neural Crest ◽  
Epithelial Stem Cells ◽  
Self Renewal ◽  
Limbal Epithelial Stem Cells

Limbal Dermoid Epithelium Shares Phenotypic Characteristics Common to Both Hair Epidermal and Limbal Epithelial Stem Cells

2013 ◽  
Vol 38 (8) ◽  
pp. 835-842 ◽  
Author(s):  
Stephanie Watson ◽  
Maria Sarris ◽  
Megha Kuishek ◽  
Penny McKelvie ◽  
Edwin Figueria ◽  
...  
Keyword(s):  
Stem Cells ◽  
Epithelial Stem Cells ◽  
Phenotypic Characteristics ◽  
Limbal Epithelial Stem Cells ◽  
Limbal Dermoid

Limbal Epithelial Stem Cells

Niche Journal ◽  
2014 ◽  
Vol 1 (3) ◽  
pp. 52-57
Author(s):  
Zuleyha Yalniz Akkaya
Keyword(s):  
Stem Cells ◽  
Epithelial Stem Cells ◽  
Limbal Epithelial Stem Cells
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