scholarly journals Genetically encoded self-assembly of large amyloid fibers

2014 ◽  
Vol 2 (4) ◽  
pp. 560-566 ◽  
Author(s):  
D. M. Ridgley ◽  
B. G. Freedman ◽  
P. W. Lee ◽  
J. R. Barone
Keyword(s):  
Self Assembly ◽  
Experimental Results ◽  
Amyloid Fibers

Experimental results demonstrate that large amyloid fibers can be engineered at the DNA level, spanning four orders of magnitude.

Dendritic nanoparticle self-assembly from drying a sessile nanofluid droplet

2021 ◽  
Author(s):  
Junheng Ren ◽  
Alexandru Crivoi ◽  
Fei Duan
Keyword(s):  
Pattern Formation ◽  
Self Assembly ◽  
Particle Deposition ◽  
Experimental Results

The pattern formation left in a drying nanofluid droplet is related to the evaporation induced particle self-assembly. The experimental results demonstrate the formation of dendritic particle deposition after the liquid...

Polymorphic transformation towards formation of nanotubes by self-assembly of an achiral molecule

Nanoscale ◽  
2015 ◽  
Vol 7 (42) ◽  
pp. 17848-17854 ◽  
Author(s):  
Shuai Wang ◽  
Yajun Zhang ◽  
Yijun Xia ◽  
Bo Song
Keyword(s):  
Theoretical Prediction ◽  
Self Assembly ◽  
Polymorphic Transformation ◽  
Experimental Results

Polymorphic transformation to nanotubes: match of experimental results and theoretical prediction.

SELF-ORGANIZED QUANTUM DOTS

2002 ◽  
Vol 12 (01) ◽  
pp. 45-78 ◽  
Author(s):  
A. R. WOLL ◽  
P. RUGHEIMER ◽  
M. G. LAGALLY
Keyword(s):  
Quantum Dots ◽  
Quantum Dot ◽  
Self Assembly ◽  
The Self ◽  
Experimental Results ◽  
Size Distributions ◽  
Ongoing Research ◽  
Kinetics And Thermodynamics ◽  
Self Organized ◽  
Formation And Evolution

We review the concepts and principal experimental results pertaining to the self-assembly and self-ordering of quantum dots in semiconductor systems. We focus on the kinetics and thermodynamics of the formation and evolution of coherently strained 3D islands, and the effects of strain on nucleation, growth, and island shape. We also discuss ongoing research on methods to control the density, size, and size distributions of strained islands, both within a single strained layer and in quantum dot (QD) multilayers.

scholarly journals Influence of metal coordination and light irradiation on hierarchical self-assembly processes

2019 ◽  
Vol 10 (3) ◽  
pp. 752-760 ◽  
Author(s):  
Kalathil K. Kartha ◽  
Naveen Kumar Allampally ◽  
Antiope T. Politi ◽  
Deepak D. Prabhu ◽  
Hayato Ouchi ◽  
...  
Keyword(s):  
Self Assembly ◽  
Experimental Results ◽  
Light Irradiation ◽  
Metal Coordination ◽  
The Impact

We unravel the impact of metal coordination and light irradiation on hierarchical self-assembly processes by combined theoretical and experimental results.

scholarly journals Capillary-based static self-assembly in higher organisms

2011 ◽  
Vol 8 (62) ◽  
pp. 1357-1366 ◽  
Author(s):  
Jonathan Voise ◽  
Michael Schindler ◽  
Jérôme Casas ◽  
Elie Raphaël
Keyword(s):  
Surface Energy ◽  
Self Assembly ◽  
Water Surface ◽  
Experimental Results ◽  
Ecological Context ◽  
Computational Approaches ◽  
Animal Groups ◽  
Theoretical Predictions ◽  
Capillary Interactions

Organized structures produced by dynamic self-assembly are often observed in animal groups. Static self-assembly, however, has to date only been observed at the cellular and sub-cellular levels. The aim of this study was to analyse organized structures in immobile whirligig beetle groups on the water surface. We used theoretical and computational approaches to model the meniscus around whirligig beetles and to calculate the surface energy for configurations involving two beetles. Theoretical predictions were then tested using live insects and resin casts. Observations were also made for three and more casts. The meniscus of whirligig beetles had a bipolar shape with two concave parts. For two beetles, predicted configurations based on energy minima corresponded to beetles in contact by their extremities, forming lines and arrows, and agreed well with observations. Experimental results for three and more beetle casts revealed new geometrical arrangements similar to those obtained with colloids at interfaces. This study provides the first example of static self-assembly at the inter-organism level and shows the importance of capillary interactions in such formations. We identify the ecological context in which our findings are of relevance.

scholarly journals Anti-biofilm Activity of Graphene Quantum Dots via Self-Assembly with Bacterial Amyloid Proteins

2019 ◽  
Author(s):  
Yichun Wang ◽  
Usha Kadiyala ◽  
Zhibei Qu ◽  
Paolo Elvati ◽  
Christopher Altheim ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Quantum Dots ◽  
Self Assembly ◽  
Graphene Quantum Dots ◽  
Robust Stabilization ◽  
Amyloid Fibers ◽  
Matrix Production ◽  
Biofilm Dispersal ◽  
Novel Strategy ◽  
Dispersal Events

ABSTRACTBacterial biofilms represent an essential part of Earth’s ecosystem that can cause multiple ecological, technological and health problems. The environmental resilience and sophisticated organization of biofilms are enabled by the extracellular matrix that creates a protective network of biomolecules around the bacterial community. Current anti-biofilm agents can interfere with extracellular matrix production but, being based on small molecules, are degraded by bacteria and rapidly diffuse away from biofilms. Both factors severely reduce their efficacy, while their toxicity to higher organisms create additional barriers to their practicality. In this paper we report on the ability of graphene quantum dots to effectively disperse mature Staphylococcus aureus biofilms, interfering with the self-assembly of amyloid fibers - a key structural component of the extracellular matrix. Mimicking peptide-binding biomolecules, graphene quantum dots form supramolecular complexes with phenol soluble modulins, the peptide monomers of amyloid fibers. Experimental and computational results show that graphene quantum dots efficiently dock near the N-terminus of the peptide and change the secondary structure of phenol soluble modulins, which disrupts their fibrillation and represents a novel strategy for mitigation of bacterial communities. GQD mediated staphylococcal biofilm dispersal. GQDs interact with PSM peptides and frustrate the fibrillation process. The reduction in amyloid fibers prevents robust stabilization of the biofilm. In addition, there is an increase in free monomeric and oligomeric PSM peptides which trigger dispersal events.

scholarly journals Synthesis and self-assembly studies of a new AIEE probe and its application in sensing amyloid fibrillation

2019 ◽  
Author(s):  
Nidhi Gour ◽  
Vivek Shinh Kshtriya ◽  
Shradhey Gupta ◽  
Ramesh, Singh ◽  
Dhawal Patel ◽  
...  
Keyword(s):  
Fluorescence Quenching ◽  
Self Assembly ◽  
Photophysical Properties ◽  
Cost Effective ◽  
The Self ◽  
Amyloid Fibers ◽  
Self Assembling ◽  
Amyloid Fibrillation ◽  
Morphological Transformations ◽  
Novel Scaffold

<p></p><p>We report self-assembly and photophysical properties of a new pyridothiazole based aggregation-induced-emission enhancement (AIEE) luminogen 4-(5-methoxy-thiazolo[4,5-b]pyridin-2-yl)benzoic acid (<b>PTC1</b>) and its application for the sensitive detection and monitoring of amyloid fibrillation. The self-assembling properties of the new AIEE probe are extensively studied by AFM and it was noted that as aggregation increases there is enhancement of fluorescence. The fluorescence of <b>PTC1 </b>is quenched upon addition of cupric (Cu<sup>2+</sup>) ions while the fluorescence is regenerated in the presence of amyloid fibers. AFM studies reveal that <b>PTC1</b> self associate/aggregate to hairy micelle structures which gets disrupted on the addition of Cu<sup>2+ </sup>and again reassembles in the presence of amyloid fibers. Hence, the fluorescence quenching and regeneration may be attributed to disaggregation and AIE respectively. Further, a comparative analysis of the performance of<b> PTC1</b> is done with the conventional ThT which confirms it to be a more sensitive probe for the detection of amyloid both in the presence and absence of Cu<sup>2+</sup>. Of note, a very simple, facile and cost-effective methodology for the detection of amyloid fibres is presented, wherein fluorescence quenching/enhancement can be visualized under UV without the use of sophisticated instrumentation techniques. To the best of our knowledge and literature survey, this is first report wherein the self-assembling properties of AIEE probe is studied extensively via microscopy and the photophysical properties compared w.r.t to the morphological transformations. The AIEE probe has been designed using an unusual pyridothiazole scaffold unlike the commonly used archetypal AIE scaffolds based on tetraphenylethene (TPE) and hexaphenylsilole (HPS) and hence, the work also has implications in designing new generation AIEE dyes based on novel scaffold reported. </p><br><p></p>

scholarly journals Synthesis and self-assembly studies of a new AIEE probe and its application in sensing amyloid fibrillation

2019 ◽  
Author(s):  
Nidhi Gour ◽  
Vivek Shinh Kshtriya ◽  
Shradhey Gupta ◽  
Ramesh, Singh ◽  
Dhawal Patel ◽  
...  
Keyword(s):  
Fluorescence Quenching ◽  
Self Assembly ◽  
Photophysical Properties ◽  
Cost Effective ◽  
The Self ◽  
Amyloid Fibers ◽  
Self Assembling ◽  
Amyloid Fibrillation ◽  
Morphological Transformations ◽  
Novel Scaffold

<p></p><p>We report self-assembly and photophysical properties of a new pyridothiazole based aggregation-induced-emission enhancement (AIEE) luminogen 4-(5-methoxy-thiazolo[4,5-b]pyridin-2-yl)benzoic acid (<b>PTC1</b>) and its application for the sensitive detection and monitoring of amyloid fibrillation. The self-assembling properties of the new AIEE probe are extensively studied by AFM and it was noted that as aggregation increases there is enhancement of fluorescence. The fluorescence of <b>PTC1 </b>is quenched upon addition of cupric (Cu<sup>2+</sup>) ions while the fluorescence is regenerated in the presence of amyloid fibers. AFM studies reveal that <b>PTC1</b> self associate/aggregate to hairy micelle structures which gets disrupted on the addition of Cu<sup>2+ </sup>and again reassembles in the presence of amyloid fibers. Hence, the fluorescence quenching and regeneration may be attributed to disaggregation and AIE respectively. Further, a comparative analysis of the performance of<b> PTC1</b> is done with the conventional ThT which confirms it to be a more sensitive probe for the detection of amyloid both in the presence and absence of Cu<sup>2+</sup>. Of note, a very simple, facile and cost-effective methodology for the detection of amyloid fibres is presented, wherein fluorescence quenching/enhancement can be visualized under UV without the use of sophisticated instrumentation techniques. To the best of our knowledge and literature survey, this is first report wherein the self-assembling properties of AIEE probe is studied extensively via microscopy and the photophysical properties compared w.r.t to the morphological transformations. The AIEE probe has been designed using an unusual pyridothiazole scaffold unlike the commonly used archetypal AIE scaffolds based on tetraphenylethene (TPE) and hexaphenylsilole (HPS) and hence, the work also has implications in designing new generation AIEE dyes based on novel scaffold reported. </p><br><p></p>

scholarly journals Conducting nanowires built by controlled self-assembly of amyloid fibers and selective metal deposition

2003 ◽  
Vol 100 (8) ◽  
pp. 4527-4532 ◽  
Author(s):  
T. Scheibel ◽  
R. Parthasarathy ◽  
G. Sawicki ◽  
X.-M. Lin ◽  
H. Jaeger ◽  
...  
Keyword(s):  
Self Assembly ◽  
Metal Deposition ◽  
Amyloid Fibers

Hierarchically Fabricated Amyloid Fibers via Evaporation-Induced Self-Assembly

ACS Nano ◽  
2021 ◽  
Author(s):  
Soon Mo Park ◽  
Massimo Bagnani ◽  
Hee Seong Yun ◽  
Moon Jong Han ◽  
Raffaele Mezzenga ◽  
...  
Keyword(s):  
Self Assembly ◽  
Amyloid Fibers ◽  
Evaporation Induced Self Assembly
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