scholarly journals Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli

2014 ◽  
Vol 2 (1) ◽  
pp. 121-130 ◽  
Author(s):  
Xin Chen ◽  
Xiaoyu Cheng ◽  
Alexander H. Soeriyadi ◽  
Sharon M. Sagnella ◽  
Xun Lu ◽  
...  
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Stimuli Responsive ◽  
Functionalized Mesoporous Silica

Size-Controlled Functionalized Mesoporous Silica Nanoparticles for Tunable Drug Release and Enhanced Anti-Tumoral Activity

2016 ◽  
Vol 28 (12) ◽  
pp. 4243-4258 ◽  
Author(s):  
Meryem Bouchoucha ◽  
Marie-France Côté ◽  
René C.-Gaudreault ◽  
Marc-André Fortin ◽  
Freddy Kleitz
Keyword(s):  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Functionalized Mesoporous Silica ◽  
Size Controlled

scholarly journals Influence of the Surface Functionalization on the Fate and Performance of Mesoporous Silica Nanoparticles

Nanomaterials ◽  
2020 ◽  
Vol 10 (5) ◽  
pp. 916 ◽  
Author(s):  
Miguel Gisbert-Garzarán ◽  
María Vallet-Regí
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Textural Properties ◽  
Stimuli Responsive ◽  
Biological Barriers ◽  
And Performance ◽  
Localized Drug Delivery

Mesoporous silica nanoparticles have been broadly applied as drug delivery systems owing to their exquisite features, such as excellent textural properties or biocompatibility. However, there are various biological barriers that prevent their proper translation into the clinic, including: (1) lack of selectivity toward tumor tissues, (2) lack of selectivity for tumoral cells and (3) endosomal sequestration of the particles upon internalization. In addition, their open porous structure may lead to premature drug release, consequently affecting healthy tissues and decreasing the efficacy of the treatment. First, this review will provide a comprehensive and systematic overview of the different approximations that have been implemented into mesoporous silica nanoparticles to overcome each of such biological barriers. Afterward, the potential premature and non-specific drug release from these mesoporous nanocarriers will be addressed by introducing the concept of stimuli-responsive gatekeepers, which endow the particles with on-demand and localized drug delivery.

Stimuli-responsive delivery vehicles based on mesoporous silica nanoparticles: recent advances and challenges

2017 ◽  
Vol 5 (7) ◽  
pp. 1339-1352 ◽  
Author(s):  
Jianhua Zhu ◽  
Yimin Niu ◽  
Yang Li ◽  
Yaxiang Gong ◽  
Huihui Shi ◽  
...  
Keyword(s):  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Drug Carrier ◽  
Stimuli Responsive ◽  
Drug Delivery Vehicles ◽  
The Past ◽  
Functionalized Mesoporous Silica ◽  
New Type ◽  
Delivery Vehicles

In the past decade, stimuli-responsive drug delivery vehicles based on surface-functionalized mesoporous silica nanoparticles have attracted intense interest as a new type of drug carrier.

scholarly journals Functionalized mesoporous silica nanoparticles templated by pyridinium ionic liquid for hydrophilic and hydrophobic drug release application

2020 ◽  
Vol 24 (3) ◽  
pp. 289-302 ◽  
Author(s):  
Nurul Syahira Zaharudin ◽  
Eleen Dayana Mohamed Isa ◽  
Haslina Ahmad ◽  
Mohd Basyaruddin Abdul Rahman ◽  
Khairulazhar Jumbri
Keyword(s):  
Ionic Liquid ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Hydrophobic Drug ◽  
Functionalized Mesoporous Silica
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