Separation of nano- and micro-sized materials by hyphenated flow and centrifugal field-flow fractionation

2014 ◽  
Vol 6 (10) ◽  
pp. 3215 ◽  
Author(s):  
Haruhisa Kato ◽  
Ayako Nakamura
Keyword(s):  
Field Flow Fractionation ◽  
Centrifugal Field ◽  
Flow Fractionation

scholarly journals Physical characterization of biomedical magnetic nanoparticles using multi-detector centrifugal field-flow fractionation

2021 ◽  
Vol 7 (2) ◽  
pp. 327-330
Author(s):  
Amani Remmo ◽  
Norbert Löwa ◽  
Julija Peter ◽  
Frank Wiekhorst
Keyword(s):  
Magnetic Properties ◽  
Magnetic Nanoparticles ◽  
Accurate Determination ◽  
Field Flow Fractionation ◽  
Centrifugal Field ◽  
Technical Approach ◽  
Present Distribution ◽  
Flow Fractionation

Abstract The unique magnetic properties of magnetic nanoparticles (MNP) combined with their small size already led to numerous medical applications. Accurate determination of their magnetic properties is a key requirement enquired by users, that is impeded by the ever-present distribution of MNP sizes. Field flow fractionation (FFF) techniques may help to overcome these limitations by first separating the particles before characterization. In this study, we demonstrate the use of centrifugal FFF coupled to online detectors for fractionation, structural, and magnetic characterization of MNP. The primary goal is to establish a reproducible centrifugal FFF (CF3) method for MNP fractionation We show that CF3 has the same capability as other FFF techniques in resolving the bimodal hydrodynamic size distribution present in the commercial MNP system Resovist® but is faster and more straightforward through its technical approach.

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