Analysis of ofloxacin and flavoxate HCl either individually or in combination via a green chromatographic approach with a pharmacokinetic study of ofloxacin in biological samples

2015 ◽  
Vol 7 (11) ◽  
pp. 4629-4639 ◽  
Author(s):  
Rania Nabih El-Shaheny ◽  
Nahed Mahmoud El-Enany ◽  
Fathalla Fathalla Belal
Keyword(s):  
Liquid Chromatography ◽  
Pharmacokinetic Study ◽  
Biological Samples ◽  
Micellar Liquid Chromatography ◽  
Chromatography Method ◽  
Biological Analysis ◽  
Liquid Chromatography Method ◽  
Flavoxate Hcl

An eco-friendly micellar liquid chromatography method was developed and validated for determination of ofloxacin and flavoxate either individually or in combined tablets in addition to biological analysis of ofloxacin.

Determination of tizoxanide, the active metabolite of nitazoxanide, by micellar liquid chromatography using a monolithic column. Application to pharmacokinetic studies

2014 ◽  
Vol 6 (21) ◽  
pp. 8682-8689 ◽  
Author(s):  
Shereen Shalan ◽  
Jenny Jeehan Nasr ◽  
Fathalla Belal
Keyword(s):  
Liquid Chromatography ◽  
Active Metabolite ◽  
Mobile Phase ◽  
Monolithic Column ◽  
Sodium Dodecyl ◽  
Micellar Liquid Chromatography ◽  
Pharmacokinetic Studies ◽  
Chromatography Method ◽  
Liquid Chromatography Method

In this study, a micellar liquid chromatography method is proposed for determination of tizoxanide, the active metabolite of nitazoxanide, using a mobile phase consisting of 0.1 M sodium dodecyl sulphate, 8%n-propanol and 0.3% triethylamine in 0.02 M phosphoric acid.

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