A simple and sensitive method for the determination of melamine in milk by first derivative UV spectrophotometry coupled with the H-point standard addition method

2013 ◽  
Vol 5 (20) ◽  
pp. 5760 ◽  
Author(s):  
Cong Li ◽  
Yanfang Li ◽  
Bing Liang ◽  
Na Li ◽  
Zhenzhen Li
Keyword(s):  
Standard Addition ◽  
Standard Addition Method ◽  
Uv Spectrophotometry ◽  
Addition Method ◽  
First Derivative ◽  
Derivative Uv Spectrophotometry ◽  
Sensitive Method

scholarly journals Combination of First Derivative Spectrophotometry and H-Point Standard Addition Method for Simultaneous Determination of Guaifenesin and Theophylline in Cough Syrup

2011 ◽  
Vol 8 (3) ◽  
pp. 966-976 ◽  
Author(s):  
R. Hajian ◽  
N. Shams ◽  
Z. Davarpanah
Keyword(s):  
Simultaneous Determination ◽  
Binary Mixtures ◽  
Standard Addition ◽  
Standard Addition Method ◽  
Determination Method ◽  
Addition Method ◽  
First Derivative ◽  
First Derivative Spectrophotometry ◽  
Cough Syrup

Combination of first derivative spectrophotometric and H-point standard addition method (HPSAM) has been applied for simultaneous determination of guaifenesin and theophylline. First derivative signals at the two pairs of wavelengths, 282.0-290.2 nm and 277.4-287.8 nm were monitored with the addition of standard solutions of both guaifenesin and theophylline in the ratio of 1:1. The method is able to accurately determine guaifenesin and theophylline (1:5 to 10:1) mole ratios. Accuracy and reproducibility of the determination method on the various amounts of guaifenesin and theophylline with known concentrations were evaluated in their binary mixtures. The recommended procedure was successfully applied to some cough syrups and synthetic mixtures with satisfactory results.

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