Design strategy for photoinduced electron transfer-based small-molecule fluorescent probes of biomacromolecules

The Analyst ◽  
2014 ◽  
Vol 139 (11) ◽  
pp. 2641-2649 ◽  
Author(s):  
Wei Zhang ◽  
Zhao Ma ◽  
Lupei Du ◽  
Minyong Li
Keyword(s):  
Electron Transfer ◽  
Small Molecule ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer ◽  
Design Strategy ◽  
Review Article ◽  
Fluorescent Imaging

This review article summarizes the advances in fluorescent probes on the basis of the photoinduced electron transfer (PET) mechanism towards diverse biomacromolecule targets, as well as their applications in fluorescent imaging.

scholarly journals Control of Intermolecular Photoinduced Electron Transfer in Deoxyadenosine‐Based Fluorescent Probes

2020 ◽  
Author(s):  
Hoang‐Ngoan Le ◽  
Johanna Brazard ◽  
Guillaume Barnoin ◽  
Steve Vincent ◽  
Benoît Y. Michel ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer

scholarly journals Thioamide Quenching of Fluorescent Probes through Photoinduced Electron Transfer: Mechanistic Studies and Applications

2013 ◽  
Vol 135 (49) ◽  
pp. 18651-18658 ◽  
Author(s):  
Jacob M. Goldberg ◽  
Solongo Batjargal ◽  
Benson S. Chen ◽  
E. James Petersson
Keyword(s):  
Electron Transfer ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer ◽  
Mechanistic Studies

Rational design of novel photoinduced electron transfer type fluorescent probes for sodium cation

Tetrahedron ◽  
2004 ◽  
Vol 60 (49) ◽  
pp. 11067-11073 ◽  
Author(s):  
Suguru Kenmoku ◽  
Yasuteru Urano ◽  
Koujirou Kanda ◽  
Hirotatsu Kojima ◽  
Kazuya Kikuchi ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer ◽  
Rational Design ◽  
Sodium Cation

Developing substrate-based small molecule fluorescent probes for super-resolution fluorescent imaging of various membrane transporters

2020 ◽  
Vol 5 (3) ◽  
pp. 523-529 ◽  
Author(s):  
Qiang Wu ◽  
Mingjun Cai ◽  
Jing Gao ◽  
Tan Zhao ◽  
Haijiao Xu ◽  
...  
Keyword(s):  
Small Molecule ◽  
Fluorescent Probes ◽  
Super Resolution ◽  
Glucose Transporters ◽  
Membrane Transporters ◽  
Fluorescent Imaging ◽  
Cellular Membranes

Glucose-based probes and tyrosine-based probes as novel small molecule fluorescent probes are synthesized for super-resolution fluorescent imaging of glucose transporters and tyrosine transporters on cellular membranes.

scholarly journals Kinetically Controlled Photoinduced Electron Transfer Switching in Cu(I)-Responsive Fluorescent Probes

2010 ◽  
Vol 132 (2) ◽  
pp. 737-747 ◽  
Author(s):  
Aneese F. Chaudhry ◽  
Manjusha Verma ◽  
M. Thomas Morgan ◽  
Maged M. Henary ◽  
Nisan Siegel ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer ◽  
Kinetically Controlled

Intramolecular photoinduced electron transfer of fluorescent probes based on 1,8-naphthalimide and aniline derivatives

2015 ◽  
Author(s):  
Natalia A. Burmistrova ◽  
Svetlana P. Mushtakova ◽  
Rufina A. Zilberg ◽  
Ivan V. Vakulin ◽  
Axel Duerkop
Keyword(s):  
Electron Transfer ◽  
Fluorescent Probes ◽  
Photoinduced Electron Transfer ◽  
Aniline Derivatives

Computationally Assisted Design of High Signal-to-Noise Photoinduced Electron Transfer-Based Voltage-Sensitive Dyes

2020 ◽  
Author(s):  
Rishikesh Kulkarni ◽  
Anneliese Gest ◽  
Chun Kei Lam ◽  
Benjamin Raliski ◽  
Feroz James ◽  
...  
Keyword(s):  
Electron Transfer ◽  
Dft Calculations ◽  
Photoinduced Electron Transfer ◽  
Density Functional ◽  
Embryonic Stem ◽  
High Sensitivity ◽  
Md Simulations ◽  
High Signal ◽  
Signal To Noise ◽  
Green Fluorescent

<p>High signal-to-noise optical voltage indicators will enable simultaneous interrogation of membrane potential in large ensembles of neurons. However, design principles for voltage sensors with high sensitivity and brightness remain elusive, limiting the applicability of voltage imaging. In this paper, we use molecular dynamics (MD) simulations and density functional theory (DFT) calculations to guide the design of a bright and sensitive green-fluorescent voltage-sensitive fluorophore, or VoltageFluor (VF dye), that uses photoinduced electron transfer (PeT) as a voltage-sensing mechanism. MD simulations predict an 11% increase in sensitivity due to membrane orientation, while DFT calculations predict an increase in fluorescence quantum yield, but a decrease in sensitivity due to a decrease in rate of PeT. We confirm these predictions by synthesizing a new VF dye and demonstrating that it displays the expected improvements by doubling the brightness and retaining similar sensitivity to prior VF dyes. Combining theoretical predictions and experimental validation has resulted in the synthesis of the highest signal-to-noise green VF dye to date. We use this new voltage indicator to monitor the electrophysiological maturation of human embryonic stem cell-derived medium spiny neurons. </p>

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