3D-printed fluidic devices enable quantitative evaluation of blood components in modified storage solutions for use in transfusion medicine

The Analyst ◽  
2014 ◽  
Vol 139 (13) ◽  
pp. 3219-3226 ◽  
Author(s):  
Chengpeng Chen ◽  
Yimeng Wang ◽  
Sarah Y. Lockwood ◽  
Dana M. Spence
Keyword(s):  
3D Printer ◽  
Transfusion Medicine ◽  
Blood Components ◽  
Storage Solutions ◽  
Fluidic Devices ◽  
Plate Reader ◽  
Fluidic Device ◽  
Standard Plate ◽  
3D Printed ◽  
Stored Blood

A fluidic device constructed with a 3D-printer can be used to investigate stored blood components with subsequent high-throughput calibration and readout with a standard plate reader.

A quantitative, in vitro appraisal of experimental low-glucose storage solutions used for blood banking

2016 ◽  
Vol 8 (38) ◽  
pp. 6856-6864 ◽  
Author(s):  
Ruipeng Mu ◽  
Chengpeng Chen ◽  
Yimeng Wang ◽  
Dana M. Spence
Keyword(s):  
Red Blood Cells ◽  
Blood Cells ◽  
Transfusion Medicine ◽  
Glucose Content ◽  
Blood Banking ◽  
Storage Solutions ◽  
3D Printed ◽  
Low Glucose ◽  
Glucose Storage

A combination of 3D printed tools and classic cellular analyses reveals the benefits of reducing the glucose content of currently approved solutions used to process and store red blood cells for transfusion medicine.

Fully 3D printed fluidic devices with integrated valves and pumps for flow injection analysis

2021 ◽  
Author(s):  
Andre D. Castiaux ◽  
Major A. Selemani ◽  
Morgan A. Ward ◽  
R. Scott Martin
Keyword(s):  
Microfluidic Device ◽  
Flow Injection ◽  
Flow Injection Analysis ◽  
3D Printer ◽  
Fluidic Devices ◽  
3D Printed ◽  
On Chip

A PolyJet 3D printer was used to create a microfluidic device with integrated valves and pumps. A flow injection analysis device that enabled the discrete injections of analyte resulted, with on-chip pumps being used to move the fluid streams.

A Study on Day Care Transfusion Services in Transfusion Medicine Department of a Tertiary Care Hospital

2019 ◽  
Vol 3 (01) ◽  
pp. 12-15
Author(s):  
Farida Parvin ◽  
Mohammed Abdul Quader ◽  
Daanish Arefin Biswas ◽  
Mohammed Ali ◽  
Bepasha Naznin ◽  
...  
Keyword(s):  
Day Care ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Fresh Frozen Plasma ◽  
Transfusion Practice ◽  
Care Hospital ◽  
Transfusion Medicine ◽  
Blood Components ◽  
Medicine Department ◽  
Long Term Study

Background: Transfusion of blood components and derivatives in day care unit is an eminent part of management of transfusion dependent patients. Day care transfusion service is an alternative to hospital admission and beneficial for those patients who receive blood more frequently for their survival. Objective: The aim of present study is to assess Transfusion Services provided in a Day Care Unit (DCU) of a tertiary care hospital. Methodology: This study was carried out in DCU of Transfusion Medicine Department, Bangabandhu Sheikh Mujib Medical University, (BSMMU) at Dhaka during January 2014 to December 2014. Data were collected from record registers. Recorded retrospective data were analyzed as percentage and proportion. Results: Total recipients were 718. Among those 424 (59.05%) were male and 294 (40.95%) were female and 562 (78.27%) were between 10 to 40 years. A total of 8587 units of blood components were used during this period. Red Cell Concentrate was most commonly utilized product 6388 (74.39%) followed by Fresh Frozen Plasma (FFP) 1360 (15.83%), Platelet Concentrate 544 (6.33%), Whole blood 260 (3.05%) and Cryoprecipitate 35 (0.40%). Transfusion was required more frequently in thalassaemic 365(50.88%) patients. Haemophilia 77(10.72%) and aplastic anaemia patients 49 (6.82%) were next high. The main transfusion reaction observed during transfusion was febrile non-haemolytic reactions. Conclusion: For increasing use of specific blood product and hassle-free transfusion services this kind of day care unit services should be strengthened. Long term study of this kind will help us to develop safe clinical transfusion practice.

scholarly journals Design and characterization of 3D printed, neomycin-eluting poly-L-lactide mats for wound-healing applications

2021 ◽  
Vol 32 (4) ◽  
Author(s):  
Mahima Singh ◽  
Sriramakamal Jonnalagadda
Keyword(s):  
Release Kinetics ◽  
Biological Properties ◽  
In Vitro Dissolution ◽  
3D Printer ◽  
Topical Antibiotic ◽  
Young’S Moduli ◽  
Base Polymer ◽  
Potential Applications ◽  
3D Printed

AbstractThis study evaluates the suitability of 3D printed biodegradable mats to load and deliver the topical antibiotic, neomycin, for up to 3 weeks in vitro. A 3D printer equipped with a hot melt extruder was used to print bandage-like wound coverings with porous sizes appropriate for cellular attachment and viability. The semicrystalline polyester, poly-l-lactic acid (PLLA) was used as the base polymer, coated (post-printing) with polyethylene glycols (PEGs) of MWs 400 Da, 6 kDa, or 20 kDa to enable manipulation of physicochemical and biological properties to suit intended applications. The mats were further loaded with a topical antibiotic (neomycin sulfate), and cumulative drug-release monitored for 3 weeks in vitro. Microscopic imaging as well as Scanning Electron Microscopy (SEM) studies showed pore dimensions of 100 × 400 µm. These pore dimensions were achieved without compromising mechanical strength; because of the “tough” individual fibers constituting the mat (Young’s Moduli of 50 ± 20 MPa and Elastic Elongation of 10 ± 5%). The in vitro dissolution study showed first-order release kinetics for neomycin during the first 20 h, followed by diffusion-controlled (Fickian) release for the remaining duration of the study. The release of neomycin suggested that the ability to load neomycin on to PLLA mats increases threefold, as the MW of the applied PEG coating is lowered from 20 kDa to 400 Da. Overall, this study demonstrates a successful approach to using a 3D printer to prepare porous degradable mats for antibiotic delivery with potential applications to dermal regeneration and tissue engineering.

Mechatronic Design of ARC Humanoid Robot Open Platform: First Fully 3D Printed Kid-Sized Robot

2020 ◽  
Vol 17 (03) ◽  
pp. 2050010
Author(s):  
Saeed Saeedvand ◽  
Hadi S. Aghdasi ◽  
Jacky Baltes
Keyword(s):  
Humanoid Robot ◽  
Size Range ◽  
Robot Design ◽  
3D Printer ◽  
Wide Angle ◽  
Open Platform ◽  
3D Printed ◽  
Wide Angle Camera ◽  
Computational Resources ◽  
User Friendly

Although there are several popular and capable humanoid robot designs available in the kid-size range, they lack some important characteristics: affordability, being user-friendly, using a wide-angle camera, sufficient computational resources for advanced AI algorithms, and mechanical robustness and stability are the most important ones. Recent advances in 3D printer technology enables researchers to move from model to physical implementation relatively easy. Therefore, we introduce a novel fully 3D printed open platform humanoid robot design named ARC. In this paper, we discuss the mechanical structure and software architecture. We show the capabilities of the ARC design in a series of experimental evaluations.

Preliminary Study of Alginates Extracted from Brown Algae (Sargassum sp.) Available in Madura Island as Composite Based Hydrogel Materials

2019 ◽  
Vol 964 ◽  
pp. 240-245 ◽  
Author(s):  
Amaliya Rasyida ◽  
Thalyta Rizkha Pradipta ◽  
Sigit Tri Wicaksono ◽  
Vania Mitha Pratiwi ◽  
Yeny Widya Rakhmawati
Keyword(s):  
Sodium Alginate ◽  
Brown Algae ◽  
Extraction Process ◽  
Composition Analysis ◽  
3D Printer ◽  
X Ray Diffraction ◽  
X Ray ◽  
3D Printed ◽  
Preliminary Study

Utilization of brown algae especially in Madura, where it’s close to Surabaya, only limited for food. This become a reference for developing and increasing the potential of this algae by extracting one of the ingredients, namely alginate. This paper deals with the characterization of sodium alginate extracted from sargassum sp. using modified-purified calcium routes. The extracted sodium alginate will be further used as composite hydrogel materials and compared with commercial sodium alginate. Hereafter, the synthesized composite is expected to be bio-ink for 3d printer. Chemical composition analysis were analyzed using X-Ray Fluorosense (XRF) followed by Fourier-transform infrared spectroscopy (FTIR) analysis to identify the functional group of composite and X-Ray Diffraction (XRD). Furthermore, viscosity bath is performed to compare the viscosity of extracted and commercial one. The result shows that modified-purified calcium routes in the extraction process of sodium alginate is desirable for improving their properties. Interestingly enough, with the goal of using it as bio-ink in 3d printed fabrication, the synthesized composite shows viscosity, 300 cSt, which meets the criteria for bio-ink in 3d printer.

scholarly journals Storage of Blood Components Does Not Decrease Haemostatic Potential: In vitro Assessment of Fresh versus Stored Blood Components Using Thromboelastography

2010 ◽  
Vol 37 (6) ◽  
pp. 329-335 ◽  
Author(s):  
Galia Bartfeld ◽  
Martin Ellis ◽  
Aharon Lubetzky ◽  
Vered Yahalom ◽  
Gili Kenet
Keyword(s):  
Blood Components ◽  
In Vitro Assessment ◽  
Stored Blood

Developments in the Field of Rapid Prototype Production

2008 ◽  
Vol 589 ◽  
pp. 421-425 ◽  
Author(s):  
Norbert Krisztián Kovács ◽  
József Gábor Kovács
Keyword(s):  
Mechanical Strength ◽  
Porous Structure ◽  
Epoxy Resin ◽  
Rapid Prototype ◽  
Post Treatment ◽  
3D Printer ◽  
Infiltration Depth ◽  
3D Printed ◽  
The Common ◽  
Polymer Engineering

Characteristics of 3D printed specimens are porous structure and low mechanical strength. Due to porous structure post treatment is possible, and in most cases infiltration with an epoxy resin, wax or cyanoacrylate material takes place. As a result of post treatment, the mechanical strength can be increased by 100%, although this is strongly influenced by the infiltration depth that depends on the porous structure and the resin viscosity. In the framework of the common research of the Department of Polymer Engineering, BME and Varinex Zrt. the applicability of a 3D printer is examined in the field of direct tool making. As the first step, the resin uptake ability of specimens prepared with a Z810 3D printer is examined.

scholarly journals Transfusion-associated adverse reactions (TAARs) and cytokine accumulations in the stored blood components: the impact of prestorage versus poststorage leukoreduction

Oncotarget ◽  
2017 ◽  
Vol 9 (4) ◽  
pp. 4385-4394 ◽  
Author(s):  
Chih-Chun Chang ◽  
Tai-Chen Lee ◽  
Ming-Jang Su ◽  
Hsiu-Chen Lin ◽  
Fang-Yi Cheng ◽  
...  
Keyword(s):  
Adverse Reactions ◽  
Blood Components ◽  
The Impact ◽  
Stored Blood

scholarly journals In-house 3D-printed surgical guides for osseous lesions of the lower jaw: an experimental study

2021 ◽  
Vol 26 (1) ◽  
Author(s):  
Lukas Postl ◽  
Thomas Mücke ◽  
Stefan Hunger ◽  
Oliver Bissinger ◽  
Michael Malek ◽  
...  
Keyword(s):  
Control Group ◽  
Head Model ◽  
Computer Assisted ◽  
3D Printer ◽  
Surgical Guide ◽  
Surgical Guides ◽  
Lower Jaw ◽  
Bony Lesion ◽  
3D Printed ◽  
Phantom Head

Abstract Background The accuracy of computer-assisted biopsies at the lower jaw was compared to the accuracy of freehand biopsies. Methods Patients with a bony lesion of the lower jaw with an indication for biopsy were prospectively enrolled. Two customized bone models per patient were produced using a 3D printer. The models of the lower jaw were fitted into a phantom head model to simulate operation room conditions. Biopsies for the study group were taken by means of surgical guides and freehand biopsies were performed for the control group. Results The deviation of the biopsy axes from the planning was significantly less when using templates. It turned out to be 1.3 ± 0.6 mm for the biopsies with a surgical guide and 3.9 ± 1.1 mm for the freehand biopsies. Conclusions Surgical guides allow significantly higher accuracy of biopsies. The preliminary results are promising, but clinical evaluation is necessary.

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