Reactions of cyclotron-produced [18F]fluoride with diaryliodonium salts—a novel single-step route to no-carrier-added [18]fluoroarenes

1995 ◽  
pp. 2215-2216 ◽  
Author(s):  
Victor W. Pike ◽  
Franklin I. Aigbirhio
Keyword(s):  
Single Step ◽  
Diaryliodonium Salts ◽  
No Carrier Added ◽  
18F Fluoride

scholarly journals Novel late-stage radiosynthesis of 5-[18F]-trifluoromethyl-1,2,4-oxadiazole (TFMO) containing molecules for PET imaging

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Nashaat Turkman ◽  
Daxing Liu ◽  
Isabella Pirola
Keyword(s):  
Late Stage ◽  
Histone Deacetylases ◽  
Radiochemical Purity ◽  
Radiochemical Yield ◽  
Single Step ◽  
The Novel ◽  
Molar Activity ◽  
The Central Nervous System ◽  
Class Iia Hdacs ◽  
18F Fluoride

AbstractSmall molecules that contain the (TFMO) moiety were reported to specifically inhibit the class-IIa histone deacetylases (HDACs), an important target in cancer and the disorders of the central nervous system (CNS). However, radiolabeling methods to incorporate the [18F]fluoride into the TFMO moiety are lacking. Herein, we report a novel late-stage incorporation of [18F]fluoride into the TFMO moiety in a single radiochemical step. In this approach the bromodifluoromethyl-1,2,4-oxadiazole was converted into [18F]TFMO via no-carrier-added bromine-[18F]fluoride exchange in a single step, thus producing the PET tracers with acceptable radiochemical yield (3–5%), high radiochemical purity (> 98%) and moderate molar activity of 0.33–0.49 GBq/umol (8.9–13.4 mCi/umol). We validated the utility of the novel radiochemical design by the radiosynthesis of [18F]TMP195, which is a known TFMO containing potent inhibitor of class-IIa HDACs.

scholarly journals An Investigation of (Diacetoxyiodo)arenes as Precursors for Preparing No-Carrier-Added [18F]Fluoroarenes from Cyclotron-Produced [18F]Fluoride Ion

2015 ◽  
Vol 81 (1) ◽  
pp. 297-302 ◽  
Author(s):  
Mohammad B. Haskali ◽  
Sanjay Telu ◽  
Yong-Sok Lee ◽  
Cheryl L. Morse ◽  
Shuiyu Lu ◽  
...  
Keyword(s):  
Fluoride Ion ◽  
No Carrier Added ◽  
18F Fluoride

Nucleophilic18F-Fluorination of Heteroaromatic Iodonium Salts with No-Carrier-Added [18F]Fluoride

2007 ◽  
Vol 129 (25) ◽  
pp. 8018-8025 ◽  
Author(s):  
Tobias L. Ross ◽  
Johannes Ermert ◽  
Carsten Hocke ◽  
Heinz H. Coenen
Keyword(s):  
Iodonium Salts ◽  
No Carrier Added ◽  
18F Fluoride

Domino N-/C- or N-/N-/C-arylation of imidazoles to yield polyaryl imidazolium salts via atom-economical use of diaryliodonium salts

2019 ◽  
Vol 55 (75) ◽  
pp. 11267-11270 ◽  
Author(s):  
Shiqing Li ◽  
Hongxu Lv ◽  
Yu Yu ◽  
Xiuqing Ye ◽  
Baisong Li ◽  
...  
Keyword(s):  
Single Step ◽  
Imidazolium Salts ◽  
Diaryliodonium Salts ◽  
Diaryliodonium Salt

A Cu-mediated domino di-/triarylation reaction of imidazoles in a single step by using two aryls as well as an anion of a diaryliodonium salt is developed to quickly achieve polyaryl imidazolium salts.

Fast Production of Highly Reactive No-Carrier-Added [18F]Fluoride for the Labeling of Radiopharmaceuticals

2010 ◽  
Vol 122 (18) ◽  
pp. 3229-3232 ◽  
Author(s):  
Christian F. Lemaire ◽  
Joël J. Aerts ◽  
Samuel Voccia ◽  
Lionel C. Libert ◽  
Frédéric Mercier ◽  
...  
Keyword(s):  
No Carrier Added ◽  
18F Fluoride

Electrochemical concentration of no-carrier-added [18F]fluoride from [18O]water in a disposable microfluidic cell for radiosynthesis of 18F-labeled radiopharmaceuticals

2010 ◽  
Vol 68 (9) ◽  
pp. 1703-1708 ◽  
Author(s):  
Hidekazu Saiki ◽  
Ren Iwata ◽  
Hiroaki Nakanishi ◽  
Rebecca Wong ◽  
Yoichi Ishikawa ◽  
...  
Keyword(s):  
No Carrier Added ◽  
18F Fluoride
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