Generation of acyl anion equivalents by in situ cathodic reduction of acyl tributylphosphonium ions anodically generated from tributylphosphine and carboxylic acids: preparation of α-hydroxy cycloalkanones from keto acids

1995 ◽  
pp. 871-872 ◽  
Author(s):  
Hatsuo Maeda ◽  
Toshihide Maki ◽  
Haruka Ashie ◽  
Hidenobu Ohmori
Keyword(s):  
Carboxylic Acids ◽  
Cathodic Reduction ◽  
Keto Acids ◽  
Acyl Anion

scholarly journals Combined Photoredox and Carbene Catalysis for the Synthesis of Ketones from Carboxylic Acids

2020 ◽  
Author(s):  
Anna Davies ◽  
keegan fitzpatrick ◽  
Rick Betori ◽  
Karl Scheidt
Keyword(s):  
Carboxylic Acids ◽  
Late Stage ◽  
Pharmaceutical Compounds ◽  
Single Electron ◽  
Photoredox Catalysis ◽  
Radical Coupling ◽  
Electron Reduction

Disclosed herein is the development of a novel single-electron reduction of acyl azoliums for the formation of ketones from carboxylic acids. Facile construction of the acyl azolium <i>in situ</i> followed by a radical-radical coupling was made possible using merged NHC-photoredox catalysis. The utility of this protocol in synthesis was demonstrated in the late-stage functionalization of a variety of pharmaceutical compounds.

Reagent-free aerobic oxidative synthesis of amides from aldehydes and isothiocyanates

2021 ◽  
Author(s):  
Jiang-Sheng Li ◽  
Xin-Yun Xie ◽  
Si Jiang ◽  
Pan-Pan Yang ◽  
Zhi-Wei Li ◽  
...  
Keyword(s):  
Carboxylic Acids

A reagent-free autoxidative reaction of aldehydes with isothiocyanates is developed to readily access amides, involving capture of carboxylic acids in situ generated from aldehydes by isothiocyanates as both coupling mediators and amine surrogates.

scholarly journals Poly(methylhydrosiloxane) as a green reducing agent in organophosphorus-catalysed amide bond formation

2017 ◽  
Vol 15 (30) ◽  
pp. 6426-6432 ◽  
Author(s):  
Daan F. J. Hamstra ◽  
Danny C. Lenstra ◽  
Tjeu J. Koenders ◽  
Floris P. J. T. Rutjes ◽  
Jasmin Mecinović
Keyword(s):  
Carboxylic Acids ◽  
Phosphine Oxide ◽  
Bond Formation ◽  
Reducing Agent ◽  
Amide Bond ◽  
Amide Bond Formation ◽  
Amidation Reaction

In situ reduction of phosphine oxide by poly(methylhydrosiloxane) leads to efficient amidation reaction between carboxylic acids and amines.

ChemInform Abstract: Esterification of Carboxylic Acids Catalyzed by in situ Generated Tetraalkylammonium Fluorides.

ChemInform ◽  
2010 ◽  
Vol 33 (11) ◽  
pp. no-no
Author(s):  
Takashi Ooi ◽  
Hayato Sugimoto ◽  
Kanae Doda ◽  
Keiji Maruoka
Keyword(s):  
Carboxylic Acids
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