A simple in situ 31P NMR method for the determination of the enantiomeric purity of aromatic substrates

1995 ◽  
pp. 689 ◽  
Author(s):  
Jillian M. Buriak ◽  
John A. Osborn
Keyword(s):  
31P Nmr ◽  
Enantiomeric Purity ◽  
Nmr Method ◽  
Aromatic Substrates

NMR method for determination of enantiomeric purity of sulfinimines

2008 ◽  
Vol 19 (23) ◽  
pp. 2645-2647 ◽  
Author(s):  
Monika Ardej-Jakubisiak ◽  
Robert Kawęcki
Keyword(s):  
Enantiomeric Purity ◽  
Nmr Method

Revision of the structure of 3-methoxy-14α-hydroxy-D-homo-1,3,5-(10)-estratrien-17a-one. A simple 1H NMR method for the determination of configuration of hydroxy group in position 5 and/or 14 of the D-homo-steroid skeleton

1991 ◽  
Vol 56 (7) ◽  
pp. 1512-1524 ◽  
Author(s):  
Miloš Buděšínský ◽  
Alexander Kasal ◽  
Želimír Procházka ◽  
Huynh Kim Thoa ◽  
Soňa Vašíčková ◽  
...  
Keyword(s):  
Hydroxy Group ◽  
Chemical Shifts ◽  
Cotton Effect ◽  
Hydroxyl Group ◽  
H Nmr ◽  
Nmr Method ◽  
Synthetic Models ◽  
Steroid Skeleton

Eignerova and Prochazka found in 1974 the Cotton effect value for 3-methoxy-14α-hydroxy-D-homo-1,3,5(10)-estratrien-17a-one (Ia) to be Δε – 2.76.Calculation of the Δε value for this compound led, however, to a substantially lower value, which suggested the hypothesis that the compound was in fact rather an epimer with the hydroxy group in position 14β. This hypothesis was studied by means of 1H NMR spectra of synthetic models, using the changes of the chemical shifts of angular methyls, induced by in situ acylation of the angular hydroxyl with an α- or β-configuration with trichloroacetyl isocyanate (TAI). The observed TAI-acylation shifts on model compounds indicated the structure Ib with a 14b-configuration of the hydroxyl group. Indenpendent proof has been given by the synthesis of both 14-hydroxy epimers, Ia and Ib. A simple 1H NMR method is proposed for the determination of configuration of the hydroxyl in position 5 or 14 of D-homo-steroid skeleton.

ChemInform Abstract: A New 31P NMR Method for the Enantiomeric Excess Determination of Alcohols, Amines, and Amino Acid Esters.

ChemInform ◽  
2010 ◽  
Vol 24 (28) ◽  
pp. no-no
Author(s):  
R. HULST ◽  
R. W. J. ZIJLSTRA ◽  
B. L. FERINGA ◽  
N. KOEN DE VRIES ◽  
W. TEN HOEVE ◽  
...  
Keyword(s):  
Amino Acid ◽  
31P Nmr ◽  
Enantiomeric Excess ◽  
Amino Acid Esters ◽  
Nmr Method ◽  
Acid Esters

A new reagent for a very simple and efficient determination of enantiomeric purity of alcohols by 31P NMR

1990 ◽  
Vol 1 (7) ◽  
pp. 437-440 ◽  
Author(s):  
Alexandre Alexakis ◽  
Stephane Mutti ◽  
Jean F. Normant ◽  
Pierre Mangeney
Keyword(s):  
31P Nmr ◽  
Enantiomeric Purity
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