Boron trifluoride-promoted reaction of 4′-nitrobenzenesulphenanilide and its N-methyl derivative with alkynes

1987 ◽  
pp. 1050-1052 ◽  
Author(s):  
Luisa Benati ◽  
P. Carlo Montevecchi ◽  
Piero Spagnolo
Keyword(s):  
Boron Trifluoride ◽  
Methyl Derivative

Synthesis of some partially methylated sucrose derivatives

1972 ◽  
Vol 25 (2) ◽  
pp. 407 ◽  
Author(s):  
GW O'Donnell ◽  
GN Richards
Keyword(s):  
Boron Trifluoride ◽  
Liquid Ammonia ◽  
Major Product ◽  
Methyl Derivative ◽  
Hydrolysis Products ◽  
Subsequent Deacetylation ◽  
Partially Methylated

1',6,6'-Tri-O-methylsucrose, a new compound, has been synthesized by methylation of 2,3,3',4,4'-penta-O-acetylsucrose with diazomethane and boron trifluoride with subsequent deacetylation. 2,3,3',4,4'-Penta-O-methylsucrose has been obtained in improved yield from the tri-O-trityl derivative by reduction with lithium in liquid ammonia. A major product of the incomplete methylation of 11,6,6'-tri-O-tritylsucrose was the 2,3,3',4'-tetra-O-methyl derivative, and after reductive detritylation 2,3,3',4'-tetra-O-methylsucrose, a new compound, was isolated and identified by examination of its hydrolysis products.

6,11-Dihydrodibenzo[b,e]thiepin-11-yl 3-quinuclidinyl ethers: New potential intidepressants and antihistamine agents

1988 ◽  
Vol 53 (8) ◽  
pp. 1806-1811 ◽  
Author(s):  
Zdeněk Polívka ◽  
Jan Metyš ◽  
Miroslav Protiva
Keyword(s):  
Methyl Derivative ◽  
Antihistamine Activity ◽  
Antidepressant Agent ◽  
Anticataleptic Activity

Reactions of 11-chloro-6,11-dihydrodibenzo[b,e]thiepin and its 2-methyl derivative, and further of the methanesulfonates of 2-chloro- and 2-bromo-6,11-dihydrodibenzo[b,e]thiepin-11-ol with 3-quinuclidinol afforded the title ethers I-IV. The 2-methyl compound II (VÚFB-17 088) showed significant antihistamine activity and the 2-chloro compound III (VÚFB-17 089), having antireserpine and anticataleptic activity, proved a potential antidepressant agent.

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