Enantiospecific synthetic approach to C,D-ring system of steroids with functionalized side-chains

1986 ◽  
pp. 288 ◽  
Author(s):  
J. H. Hutchinson ◽  
T. Money
Keyword(s):  
Ring System ◽  
Synthetic Approach ◽  
Side Chains ◽  
Functionalized Side

Self-organization of comblike copolymers with end-functionalized side chains: A cellular-automaton-based simulation

2000 ◽  
Vol 112 (24) ◽  
pp. 11069-11079 ◽  
Author(s):  
David G. Shirvanyanz ◽  
Alexander S. Pavlov ◽  
Pavel G. Khalatur ◽  
Alexei R. Khokhlov
Keyword(s):  
Cellular Automaton ◽  
Self Organization ◽  
Side Chains ◽  
Functionalized Side

Development of a Healable Bulk Heterojunction Using Conjugated Donor Polymers Based on Thymine-Functionalized Side Chains

2021 ◽  
Vol 54 (7) ◽  
pp. 3478-3488
Author(s):  
Seongwon Yoon ◽  
Keun Jun Lee ◽  
Sungmin Park ◽  
Taehee Kim ◽  
Sang Hyuk Im ◽  
...  
Keyword(s):  
Bulk Heterojunction ◽  
Side Chains ◽  
Functionalized Side

scholarly journals The role of side chains in the interaction of new antitumor pyrimidoacridinetriones with DNA: molecular dynamics simulations.

2000 ◽  
Vol 47 (1) ◽  
pp. 47-57 ◽  
Author(s):  
J Mazerski ◽  
I Antonini ◽  
S Martelli
Keyword(s):  
Molecular Dynamics ◽  
Rational Design ◽  
Md Simulations ◽  
Ring System ◽  
Side Chain ◽  
Side Chains ◽  
Intercalation Complex ◽  
Highly Active ◽  
Simulation Techniques ◽  
Dynamics Simulations

Pyrimidoacridinetriones (PATs) are a new group of highly active antitumor compounds. It seems reasonable to assume that, like for some other acridine derivatives, intercalation into DNA is a necessary, however not a sufficient condition for antitumor activity of these compounds. Rational design of new compounds of this chemotype requires knowledge about the structure of the intercalation complex, as well as about interactions responsible for its stability. Computer simulation techniques such as molecular dynamics (MD) may provide valuable information about these problems. The results of MD simulations performed for three rationally selected PATs are presented in this paper. The compounds differ in the number and position of side chains. Each of the compounds was simulated in two systems: i) in water, and ii) in the intercalation complex with the dodecamer duplex d(GCGCGCGCGCGC)2. The orientation of the side chain in relation to the ring system is determined by the position of its attachment. Orientation of the ring system inside the intercalation cavity depends on the number and position of side chain(s). The conformations of the side chain(s) of all PATs studied in the intercalation complex were found to be very similar to those observed in water.

ChemInform Abstract: A New Synthetic Approach to the Rotenoid Ring System.

ChemInform ◽  
1990 ◽  
Vol 21 (3) ◽  
Author(s):  
S. M. F. LAI ◽  
J. J. A. ORCHISON ◽  
D. A. WHITING
Keyword(s):  
Ring System ◽  
Synthetic Approach

ChemInform Abstract: Enantioselective Iridium-Catalyzed Allylic Aminations of Allylic Carbonates with Functionalized Side Chains. Asymmetric Total Synthesis of (S)-Vigabatrin.

ChemInform ◽  
2009 ◽  
Vol 40 (9) ◽  
Author(s):  
Christian Gnamm ◽  
Geraldine Franck ◽  
Nicole Miller ◽  
Timon Stork ◽  
Kerstin Broedner ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Side Chains ◽  
Asymmetric Total Synthesis ◽  
Functionalized Side
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