Asymmetric synthesis of (R)-α-phenylalkylamines via alkylation of chiral hydrazones by Grignard reagents

1979 ◽  
pp. 668-669 ◽  
Author(s):  
Hiroshi Takahashi ◽  
Kouichi Tomita ◽  
Hirotaka Otomasu
Keyword(s):  
Asymmetric Synthesis ◽  
Grignard Reagents

scholarly journals Substrate-controlled Diastereoselective Michael Addition of Alkylidene Malonates by Grignard Reagents

2019 ◽  
Vol 25 (1) ◽  
pp. 116-121
Author(s):  
Wei Zhou ◽  
Qingwei Xiao ◽  
Yuanyuan Chang ◽  
Qifa Liu ◽  
Xiaohao Zang ◽  
...  
Keyword(s):  
Amino Acid ◽  
Asymmetric Synthesis ◽  
Michael Addition ◽  
Chiral Auxiliary ◽  
Grignard Reagents ◽  
Amino Acid Derivatives ◽  
Catalyst Free ◽  
Chemical Efficiency

AbstractHerein is described a diastereoselective Michael addition of Grignard reagents to α, β- unsaturated diethyl malonates incorporated with a 2-oxazolidone chiral auxiliary. The catalyst-free Michael addition proceeds with good chemical efficiency and excellent stereoselectivity; and it provides new thoughts to the asymmetric synthesis of β-substituted β3 amino acid derivatives.

The asymmetric synthesis of α-amino acids via the addition of grignard reagents to imine derivatives.

Tetrahedron ◽  
1992 ◽  
Vol 48 (24) ◽  
pp. 5163-5178 ◽  
Author(s):  
David P.G. Hamon ◽  
Ralph A. Massy-Westropp ◽  
Pasquale Razzino
Keyword(s):  
Amino Acids ◽  
Asymmetric Synthesis ◽  
Grignard Reagents
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