General synthesis of optically pure chiral iron primary alkyls via a metal-activated alkylation reagent

1975 ◽  
pp. 336 ◽  
Author(s):  
Thomas C. Flood ◽  
Frank J. DiSanti ◽  
David L. Miles
Keyword(s):  
Alkylation Reagent ◽  
Optically Pure ◽  
General Synthesis

New methods and reagents in organic synthesis. 67. A general synthesis of derivatives of optically pure 2-(1-aminoalkyl)thiazole-4-carboxylic acids

1987 ◽  
Vol 52 (7) ◽  
pp. 1252-1255 ◽  
Author(s):  
Yasumasa Hamada ◽  
Makoto Shibata ◽  
Tsuneyuki Sugiura ◽  
Shinji Kato ◽  
Takayuki Shioiri
Keyword(s):  
Carboxylic Acids ◽  
Organic Synthesis ◽  
New Methods ◽  
Optically Pure ◽  
Derivatives Of ◽  
General Synthesis

A Peptoid with Extended Shape in Water

2019 ◽  
Author(s):  
Jumpei Morimoto ◽  
Yasuhiro Fukuda ◽  
Takumu Watanabe ◽  
Daisuke Kuroda ◽  
Kouhei Tsumoto ◽  
...  
Keyword(s):  
Spectroscopic Analysis ◽  
Dimensional Space ◽  
Three Dimensional ◽  
Biomolecular Recognition ◽  
Biological Application ◽  
New Class ◽  
Proteolytic Resistance ◽  
Pharmacokinetic Properties ◽  
Optically Pure ◽  
Three Dimensional Space

<div> <div> <div> <p>“Peptoids” was proposed, over decades ago, as a term describing analogs of peptides that exhibit better physicochemical and pharmacokinetic properties than peptides. Oligo-(N-substituted glycines) (oligo-NSG) was previously proposed as a peptoid due to its high proteolytic resistance and membrane permeability. However, oligo-NSG is conformationally flexible and is difficult to achieve a defined shape in water. This conformational flexibility is severely limiting biological application of oligo-NSG. Here, we propose oligo-(N-substituted alanines) (oligo-NSA) as a new peptoid that forms a defined shape in water. A synthetic method established in this study enabled the first isolation and conformational study of optically pure oligo-NSA. Computational simulations, crystallographic studies and spectroscopic analysis demonstrated the well-defined extended shape of oligo-NSA realized by backbone steric effects. The new class of peptoid achieves the constrained conformation without any assistance of N-substituents and serves as an ideal scaffold for displaying functional groups in well-defined three-dimensional space, which leads to effective biomolecular recognition. </p> </div> </div> </div>

General Synthesis of Ordered Mesoporous Carbonaceous Hybrid Nanostructures with Molecularly Dispersed Polyoxometallates

2021 ◽  
Author(s):  
Chaoliang Tan ◽  
Chunhong Chen ◽  
Shanjun Mao ◽  
Zhe Wang ◽  
Yiyao Ge ◽  
...  
Keyword(s):  
Hybrid Nanostructures ◽  
Ordered Mesoporous ◽  
General Synthesis

Transition metal-free approach to azafluoranthene scaffolds by aldol condensation/[1+2+3] annulation tandem reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes

2021 ◽  
Author(s):  
Penghui Dong ◽  
Kashif Majeed ◽  
lingna Wang ◽  
Zijian Guo ◽  
Fengtao Zhou ◽  
...  
Keyword(s):  
Transition Metal ◽  
Aldol Condensation ◽  
Domino Reaction ◽  
Tandem Reaction ◽  
Metal Free ◽  
Successive Formation ◽  
General Synthesis

A transition metal-free aldol condensation/[1+2+3] annulation reaction of isocyanoacetates with 8-(alkynyl)-1-naphthaldehydes has been developed for the general synthesis of azafluoranthenes. This domino reaction enables successive formation of three new bonds...

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